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4 peer-reviewed studies
What the evidence says
Most D-Chiro-Inositol studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from medium-quality meta-analyses and randomised trials published 2017–2024.
Based on 4 studies · 2 meta-analyses · 1 RCT
Confidence
HighBy outcome
3 studies in the last 5 years · Latest meta-analysis: 2024
A systematic review/meta-analysis found possible metabolic/ovulatory benefits from inositol in PCOS but concluded the evidence is limited and inconclusive.
Fitz V et al. · J Clin Endocrinol Metab (2024)
A randomized trial found a myo-inositol + D-chiro-inositol combination (550 + 150 mg) restored spontaneous menstrual cycles in most women with PCOS.
Kachhawa G et al. · Int J Gynaecol Obstet (2022)
A Cochrane review of insulin-sensitizing agents found benefit (mainly metformin); for D-chiro-inositol specifically it could draw no conclusions.
Morley LC et al. · Cochrane Database Syst Rev (2017)
A review described myo-inositol and D-chiro-inositol as modulators of ovarian steroidogenesis.
Bizzarri M et al. · Nutrients (2023)