1Meta-Analysis2022
Colacci M, Fralick J, Odutayo A, Fralick M · Can J Diabetes (2022)
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801 peer-reviewed studies
What the evidence says
Most Dapagliflozin studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 2009–2026 with a typical study size of 238 participants.
Based on 799 studies · 214 meta-analyses · 533 RCTs · 131,798 total participants
Confidence
High confidenceBy outcome
521 studies in the last 5 years · Latest meta-analysis: 2026
Colacci M, Fralick J, Odutayo A, Fralick M · Can J Diabetes (2022)
Fernandes JV, Ramos JV, Holanda MM · Minerva Med (2025)
Banerjee M, Pal R, Maisnam I, Chowdhury S, Mukhopadhyay S · Diabetes Obes Metab (2023)
Zheng Z, He D, Chen J, Xie X, Lu Y, Wu B · Clin Drug Investig (2023)
Zhang HD, Ding L, Mi LJ, Zhang AK, Zhang K, Jiang ZH · Eur J Prev Cardiol (2024)
Wang LG, Wang H, Liu Q, Hua WC, Li CM · Biomed Pharmacother (2017)
Jhund PS, Kondo T, Butt JH, Docherty KF, Claggett BL, Desai AS · Nat Med (2022)
Tang HL, Li DD, Zhang JJ, Hsu YH, Wang TS, Zhai SD · Diabetes Obes Metab (2016)
Musso G, Gambino R, Cassader M, Pagano G · Ann Med (2012)
Adamou A, Chlorogiannis DD, Kyriakoulis IG, Stamatiou I, Koukousaki D, Kardoutsos I · Intern Emerg Med (2024)
Langford BE, Evans M, Haskins-Coulter T, O'Connor M, Cant HEO, Eddowes LA · Diabetes Obes Metab (2020)
Tsai PC, Chuang WJ, Ko AM, Chen JS, Chiu CH, Chen CH · Cardiovasc Diabetol (2023)
Ida S, Kaneko R, Imataka K, Okubo K, Shirakura Y, Azuma K · Curr Diabetes Rev (2021)
Tomasoni D, Adamo M, Lombardi CM, Metra M · ESC Heart Fail (2019)
Tong X, Song X, Zhang Y, Zhao Q · Arch Physiol Biochem (2024)
Zheng Y, Sun J · Medicine (Baltimore) (2025)
Li D, Liu Y, Hidru TH, Yang X, Wang Y, Chen C · Front Endocrinol (Lausanne) (2021)
Fadini GP, Li Volsi P, Devangelio E, Poli M, Cazzetta G, Felace G · J Endocrinol Invest (2020)
Gilbert RE, Thorpe KE · Diabetes Obes Metab (2019)
Johnsson KM, Ptaszynska A, Schmitz B, Sugg J, Parikh SJ, List JF · J Diabetes Complications (2013)