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Dgl4.5
DGL Licorice Research
Mostly mechanism / observational
95 peer-reviewed studies
What the evidence says
Mostly mechanism / observational
Most DGL Licorice studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 1965–2026 with a typical study size of 83 participants.
Based on 95 studies · 9 meta-analyses · 78 RCTs · 461 total participants
Confidence
High confidence
By outcome
Digestive & gastric mucosaOne small RCT eased functional dyspepsia; reflux/ulcer evidence is thin and dated · 2-4 weeks
Mostly mechanism / observational25 studies
Oral & dental health
Mostly mechanism / observational14 studies
Therapeutic & clinical
Mostly mechanism / observational5 studies
Safety profile
Mostly mechanism / observational5 studies
Heart & blood pressure
Mostly mechanism / observational4 studies
Liver health
Too few graded studies2 studies
Steady research
28 studies in the last 5 years · Latest meta-analysis: 2024
196519952026
1H. pylori eradication ratesMeta-Analysis2023
Polyphenol compounds plus standard triple therapy can significantly improve the eradication.
Wang Q et al. · BMJ Open (2023)
Meta-analysis of polyphenol compounds including liquorice for H. pylori eradication (12 RCTs)
Overall eradication rate was higher with polyphenol compounds (RR 1.19, 95% CI 1.03 to 1.38, p=0.02)
Polyphenols plus triple therapy outperformed triple therapy alone (RR 1.11, 95% CI 1.01 to 1.22, p=0.03), with no increase in side effects
2Phytochemistry and biological/clinical activities of licoriceSystematic Review2021
There are various beneficial effects of licorice root extracts, such as treating throat infections, tuberculosis, respiratory, liver diseases, antibacterial, anti-inflammatory, and immunodeficiency.
Wahab S et al. · Plants (Basel) (2021)
Comprehensive review of licorice ethnopharmacology, phytochemistry, biological activities, and clinical evidence
Anti-inflammatory and antibacterial activities attributed to flavonoids isoliquiritigenin, liquiritigenin, lichalcone, and glabridin
Notes licorice as a candidate natural alternative with mild side effects, warranting further clinical study