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Dgl6.0

DGL Licorice Research

Mostly mechanism / observationalHigh safety

5 peer-reviewed studies

What the evidence says

Mostly mechanism / observational

Most DGL Licorice studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.

Most evidence is from high-quality randomised trials published 1975–2025 with a typical study size of 296 participants.

Based on 5 studies · 3 RCTs · 1,878 total participants

Confidence

Moderate

What the studies found

1helped· 4 more without graded effect data

By outcome

Digestive & gastric mucosaReduced heartburn and improved gut lining protection within 2-4 weeks · 2-4 weeks
Mostly mechanism / observational5 studies
Safety profile
Too few graded studies2 studies
Heart & blood pressure
Too few graded studies1 study

Active research area

3 studies in the last 5 years

197520002025

1H. pylori eradication ratesSystematic Reviewn=520 · large study2022

Licorice root extract demonstrated anti-H. pylori activity and enhanced standard triple therapy eradication rates.

Hajiaghamohammadi AA et al. · World Journal of Gastroenterology (2022)

Licorice extract boosted H. pylori eradication rates when added to standard therapy
Anti-adhesion and anti-inflammatory mechanisms reduce gastric mucosal damage
DGL form preferred for long-term use to avoid mineralocorticoid side effects

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2Functional dyspepsia and ulcer healingSystematic ReviewCited 15×n=980 · large study2021

Deglycyrrhizinated licorice showed significant benefits for functional dyspepsia and mucosal protection.

Wahab S et al. · Phytotherapy Research (2021)

DGL accelerated ulcer healing in gastric and duodenal ulcer patients
Functional dyspepsia symptoms improved significantly in controlled trials
DGL form avoids aldosterone-related side effects of whole licorice

3Dyspepsia symptomsRCTCited 44×n=50 · small study2012

Licorice extract significantly improved dyspepsia symptoms.

Raveendra KR et al. · Evidence-Based Complementary and Alternative Medicine (2012)

Reduced dyspepsia symptoms
Improved quality of life

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4RCTn=296 · medium study2025

The GutGard® group showed better and earlier resolution (within 2 weeks) of symptoms of GER as against the placebo group, especially heartburn and regurgitation.

Raj JP et al. · Complementary medicine research (2025)

Participants in the GutGard® group reported a significantly better quality of life at the end of the intervention period (p = 0.014).
They also reported earlier resolution of symptoms of GER as against the placebo group, especially the symptoms of heartburn (p = 0.017 on day 14 and p = 0.005 on day 28) and regurgitation (p = 0.025 on day 7, p = 0.029 on day 14, and p = 0.022 on day 28).
Further research warranted to confirm findings

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5Duodenal ulcer healingRCTn=32 · small study1975

DGL promoted ulcer healing in most patients.

Larkworthy W, Holgate PF · Practitioner (1975)

Huge benefit

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