44 peer-reviewed studies · Evidence score: 9/10
Zhu F et al. • Reproductive biology and endocrinology : RB&E (2023)
Compared with COS regimen, the adjuvant use of CoQ10, DHEA and GH before IVF may have a better clinical effect on the pregnancy outcome of POR patients.
Chen Y et al. • Postgraduate medicine (2024)
This meta-analysis indicates that reduced levels of DHEA-S, testosterone, estrogen may serve as potential risk factors for pulmonary fibrosis.
Wang J et al. • Combinatorial chemistry & high throughput screening (2023)
Oral DHEA supplementation appears to improve some IVF outcomes.
Jeyaprakash N et al. • Archives of gynecology and obstetrics (2023)
This systematic-review examined the effects of DHEA.
Zhang Y et al. • Human reproduction update (2020)
Furthermore, high-level RCT studies using uniform standards for POR need to be incorporated into future meta-analyses.
Misiak B et al. • Psychoneuroendocrinology (2018)
Effect size (ES) estimates were calculated as Hedges' g.
Elraiyah T et al. • The Journal of clinical endocrinology and metabolism (2014)
Evidence warranting low confidence suggests that DHEA administration does not significantly impact sexual symptoms or selected metabolic markers in postmenopausal women with normal adrenal function.
Conforti A et al. • Fertility and sterility (2025)
Specific interventions such as testosterone seem to correlate with a better live birth rate in women with DOR; these findings should be further explored in randomized trials.
Jafar NKA et al. • Clinical endocrinology (2025)
SHBG, rather than hyperandrogenism, may play a more important mechanistic role for OSA in PCOS, while other sleep disturbances exhibit a less severe SHBG profile.
Peixoto C et al. • Journal of neuroscience research (2020)
However, these results should be viewed with caution, since the quality of evidence for this outcome was considered very low according to the GRADE criteria.
Casiano Evans EA et al. • Obstetrics and gynecology (2023)
Most nonestrogen therapies are effective treatments for the various symptoms of GSM.
Ali Fadlalmola H et al. • The Pan African medical journal (2023)
In combination with other treatments, especially for hyperlipidemia, resveratrol is beneficial for women diagnosed with PCOS.Copyright: Hammad Ali Fadlalmola et al.
Thavaraputta S et al. • European journal of endocrinology (2023)
Women with anorexia nervosa have higher cortisol levels and lower DHEA-S and testosterone levels compared to women without anorexia nervosa.
Danan ER et al. • Annals of internal medicine (2024)
Vaginal estrogen, vaginal DHEA, oral ospemifene, and vaginal moisturizers may improve some GSM symptoms in the short term.
Khade DM et al. • International orthodontics (2023)
The current evidence suggests that salivary biomarkers can be used as an adjunct for growth prediction during orthodontic treatment planning along with other methods of skeletal maturation assessment.
Sultana F et al. • Menopause (New York, N.Y.) (2023)
Overall, this systematic review does not support a beneficial effect of DHEA therapy on cognitive performance in postmenopausal women.
Zouhal H et al. • Sports medicine (Auckland, N.Z.) (2022)
In conclusion, findings from this systematic review suggest that exercise training increases basal levels of testosterone, IGF-1, SHBG, hGH and DHEA in both male and females over 40 years of age.
Sarmento ACA et al. • Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia (2022)
We identified literature that lacks coherence in terms of the proposed treatments and selected outcome measures.
van Zuiden M et al. • Psychoneuroendocrinology (2017)
A trend for higher DHEA levels was found in PTSD patients compared to non-trauma-exposed controls (NTC) (k=3, SMD=1.12 95% CI -0.03-2.52, Z=1.91, p=0.06).
Lin J et al. • The International journal of eating disorders (2022)
Potential detrimental effects on BMD were identified in younger adolescents with open physes in one study.