Dh7.5

DHM Research

39 peer-reviewed studies · Evidence score: 7.5/10

Prophylactic Agents for Preventing Cardiotoxicity Induced Following Anticancer Agents: A Systematic Review and Meta-Analysis of Clinical Trials

Keshavarzian E et al. • Reviews on recent clinical trials (2023)

This meta-analysis showed that prophylactic treatment with cardio-protective drugs, including dexrazoxane, beta blocker, and ACEI drugs in patients undergoing chemotherapy with anthracycline, have a protective effect on LVEF and prevent EF drop.

Through comparison of the two groups, EF was found to increase in the intervention group by 0.40 after 6 months (Standardized mean difference (SMD): 0.40, 95% confidence interval (CI): 0.27, 0.54), thus proving higher than that of the control groups following the cardiac drugs.
This meta-analysis showed that prophylactic treatment with cardio-protective drugs, including dexrazoxane, beta blocker, and ACEI drugs in patients undergoing chemotherapy with anthracycline, have a protective effect on LVEF and prevent EF drop.
Further research warranted to confirm findings

Meta-Analysisn=2,674

DOI

Autophagy in High-Fat Diet and Streptozotocin-Induced Metabolic Cardiomyopathy: Mechanisms and Therapeutic Implications

Zhou R et al. • International journal of molecular sciences (2025)

A deeper understanding of autophagy's regulatory networks, particularly involving these critical genes and proteins, may lead to novel therapeutic approaches for treating metabolic cardiomyopathy.

Additionally, selective autophagy processes such as lipophagy, regulated by PNPLA8, and ferritinophagy, modulated by NCOA4, play pivotal roles in lipid metabolism and iron homeostasis.
Emerging therapeutic strategies targeting autophagy, including plant extracts (e.g., curcumin, dihydromyricetin), endogenous compounds (e.g., sirtuin 3, LC3), and lipid/glucose-lowering drugs, offer promising avenues for mitigating the effects of metabolic cardiomyopathy.
Despite recent advances, the precise mechanisms underlying autophagy in this context remain poorly understood.

Systematic Review

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Sirtuins regulate macrophage polarization in heart failure: Metabolic reprogramming, epigenetic regulation, and immune cell interactions

Lin R et al. • Pharmacological research (2025)

This review aims to provide a theoretical framework and translational guidance for developing HF-targeted therapeutic strategies based on Sirtuin-mediated macrophage polarization, as well as for th...

This review aims to provide a theoretical framework and translational guidance for developing HF-targeted therapeutic strategies based on Sirtuin-mediated macrophage polarization, as well as for the research and development of related natural products.

Systematic Review

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Metabolic mechanisms of Dihydromyricetin and strategies for enhancing its bioavailability: A recent review

Hou G et al. • Food chemistry (2025)

It examines the key factors influencing its bioavailability and highlights the design and construction of various bio-based delivery systems aimed at improving its bioavailability.

It examines the key factors influencing its bioavailability and highlights the design and construction of various bio-based delivery systems aimed at improving its bioavailability.
Furthermore, the paper explores the potential applications of these delivery systems.
The development of such systems can significantly enhance the stability and bioavailability of dihydromyricetin, providing a solid theoretical foundation for advancing its use in food and medicine.

Systematic Review

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Oxidative stress and inflammation in renal fibrosis: Novel molecular mechanisms and therapeutic targets

Liu H et al. • Chemico-biological interactions (2025)

Novel therapeutic strategies targeting IκB/NF-κB, Keap1/Nrf2, NOX4, TGF-β/Smad and AHR pathways, such as small-molecule inhibitors, antioxidant agents, and antiinflammatory cytokines, show promise ...

Novel therapeutic strategies targeting IκB/NF-κB, Keap1/Nrf2, NOX4, TGF-β/Smad and AHR pathways, such as small-molecule inhibitors, antioxidant agents, and antiinflammatory cytokines, show promise in mitigating renal fibrosis.
This review synthesizes recent advances in understanding molecular mechanisms of renal fibrosis and highlights potential therapeutic targets, offering insights into innovative strategies for managing CKD and improving patient outcomes.Copyright © 2025 Elsevier B.V.

Systematic Review

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[Efficacy, safety, and mechanism of Huangkui Capsules in treating chronic kidney disease: Meta-analysis and integrative bioinformatics]

Wang FP et al. • Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (2023)

More clinical trial protocols with large sample sizes and rigorous design and in line with international norms are needed to improve the evidence quality, and the results of bioinformatics analysis remain to be confirmed by further studies.

Meta-analysis showed that the Huangkui Capsules group and the losartan potassium group had no significant differences in reducing the urinary protein levels after 12(MD=19.60, 95%CI[-58.66, 97.86], P=0.62) and 24 weeks(MD=-66.00, 95%CI[-264.10, 132.11], P=0.51) of treatment.
Huangkui Capsules in combination with conventional treatment was superior to conventional treatment alone(MD=-0.55, 95%CI[-0.86,-0.23], P=0.000 6).
Huangkui Capsules combined with conventional treatment was superior to conventional treatment alone in recovering Scr(MD=-9.21, 95%CI[-15.85,-2.58], P=0.006) and BUN(MD=-1.02, 95%CI[-1.83,-0.21], P=0.01).

Meta-Analysisn=372

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Polyphenols as potential metabolism mechanisms regulators in liver protection and liver cancer prevention

Li S et al. • Cell proliferation (2023)

This review systematically illustrates that various polyphenols, including resveratrol, chlorogenic acid, caffeic acid, dihydromyricetin, quercetin, catechins, curcumin, etc., improve metabolic disorders through direct or indirect pathways to protect the liver and fight liver cancer.

This review systematically illustrates that various polyphenols, including resveratrol, chlorogenic acid, caffeic acid, dihydromyricetin, quercetin, catechins, curcumin, etc., improve metabolic disorders through direct or indirect pathways to protect the liver and fight liver cancer.
Further research warranted to confirm findings

Systematic Review

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Natural products in traditional Chinese medicine: molecular mechanisms and therapeutic targets of renal fibrosis and state-of-the-art drug delivery systems

Song L et al. • Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (2024)

This may provide new ideas for using natural products for RF treatment.

This may provide new ideas for using natural products for RF treatment.
Finally, we provide new insights into the clinical prospects of herbal natural products.

Systematic Review

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Cell plasticity modulation by flavonoids in resistant breast carcinoma targeting the nuclear factor kappa B signaling

Kubatka P et al. • Cancer metastasis reviews (2024)

This systematic-review examined the effects of DHM.

Besides that, NF-κB signaling in BC cells modulated by flavonoids has also involved the regulation of ATP-binding cassette transporters, apoptosis, autophagy, cell cycle, and changes in the activity of cancer stem cells, oncogenes, or controlling of gene repair.
The evaluation of conventional therapies in combination with plasticity-regulating/sensitizing agents offers new opportunities to make significant progress towards a complete cure for cancer.
Further research warranted to confirm findings

Systematic Review

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Progress in the mechanism of autophagy and traditional Chinese medicine herb involved in alcohol-related liver disease

Han W et al. • PeerJ (2023)

The regulation of autophagy in ALD by these traditional Chinese medicine extracts provides novel ideas for the treatment of the disease; however, its molecular mechanism needs to be elucidated further.

Therefore, autophagy plays an critical role in the occurrence and development of ALD.
Some studies have shown that traditional Chinese medicine extracts improve the histological characteristics of ALD, as reflected in the improvement of oxidative stress and lipid droplet clearance, which might be achieved by inducing autophagy.
This article reviews the mechanisms of quercetin, baicalin, glycycoumarin, salvianolic acid A, resveratrol, ginsenoside rg1, and dihydromyricetin inducing autophagy and their participation in the inhibition of ALD.

Systematic Review

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Research progress of dihydromyricetin in the treatment of diabetes mellitus

Wang Z et al. • Frontiers in endocrinology (2023)

In this review, following with a brief introduction of the absorption, metabolism, distribution, and excretion characteristics of DMY, we summarized the current pharmacological developments of DMY as well as possible molecular mechanisms in the treatment of DM, aiming to push the understanding about the protective role of DMY as well as its preclinical assessment of novel application.

A detailed summary of related signaling induced by DMY are discussed.
Hence, the mechanisms underlying the therapeutic implications of DMY in DM are still obscure.
Further research warranted to confirm findings

Systematic Review

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Therapeutic potential of natural molecules against Alzheimer's disease via SIRT1 modulation

Zhang M et al. • Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (2023)

The natural molecules modulating SIRT1 discussed in this review provide a potentially novel multi-mechanistic therapeutic strategy for AD.

The natural molecules modulating SIRT1 discussed in this review provide a potentially novel multi-mechanistic therapeutic strategy for AD.
However, future clinical trials need to be conducted to further investigate their beneficial properties and to determine the safety and efficacy of SIRT1 natural activators against AD.

Systematic Review

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NLRP3 Inflammasome in Atherosclerosis: Putting Out the Fire of Inflammation

Shao BZ et al. • Inflammation (2023)

The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Furthermore, the role of the NLRP3 inflammasome in AS and the possible mechanisms will be discussed.
We aim to provide novel insights in the exploration of the specific mechanisms of AS and the development of new treatments of AS.
The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Systematic Review

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Molecular mechanisms and promising role of dihydromyricetin in cardiovascular diseases

Nie H et al. • Physiological research (2022)

The aim of this review is to provide a better understanding and quick overview for future researches of dihydromyricetin in the field of cardiovascular diseases, and more detailed and robust researches are needed for evaluation and reference.

In addition, DMY may play a role in cardiovascular disease by resisting oxidative stress and participating in the regulation of inflammation.
This review is the first review that summaries the applications of dihydromyricetin in cardiovascular diseases, including atherosclerosis, myocardial infarction, myocardial hypertrophy, and diabetic cardiomyopathy.
We also clarified the underlying mechanisms and signaling pathways involved in the above process.

Systematic Review

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Therapeutic potential of autophagy activators and inhibitors in lung and breast cancer- a review

Mudaliar P et al. • Molecular biology reports (2022)

The Author(s), under exclusive licence to Springer Nature B.V.

While several autophagy activators, and inhibitors, such as SAH-EJ2, Gefitinib, Ampelopsin hydroxychloroquine and chloroquine, are utilized to regulate autophagy in chemoprevention, the exact intrinsic system of autophagy in cancer deserves further investigation.
Despite improved treatment regimens, the incidence rate of both breast and lung cancer has grown, as has the number of recurrence cases.
The Author(s), under exclusive licence to Springer Nature B.V.

Systematic Review

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Recent update on application of dihydromyricetin in metabolic related diseases

Wang Y et al. • Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (2022)

In addition, the mechanism of DMY on these diseases was also related to the signal pathway of AMPK, PI3K/Akt, PPAR and the participation of microRNAs.

In addition, the mechanism of DMY on these diseases was also related to the signal pathway of AMPK, PI3K/Akt, PPAR and the participation of microRNAs.
This review describes the mechanism of DMY in metabolic related diseases from three aspects: metabolic diseases, liver diseases, and cancers, hoping to provide some new ideas for clinical researches.

Systematic Review

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Molecular inhibition of RAS signalling to target ageing and age-related health

Laskovs M et al. • Disease models & mechanisms (2022)

Here, we review evidence that RAS/MAPK signalling inhibitors already in clinical use, such as trametinib, acarbose, statins, metformin and dihydromyricetin, lead to lifespan extension and to improv...

Here, we review evidence that RAS/MAPK signalling inhibitors already in clinical use, such as trametinib, acarbose, statins, metformin and dihydromyricetin, lead to lifespan extension and to improved healthspan in a range of model systems.
These findings suggest that the repurposing of small molecule inhibitors of RAS/MAPK signalling might offer opportunities to improve health during ageing, and to delay or prevent the development of age-related disease.
However, challenges to this approach, including poor tolerance to treatment in older adults or development of drug resistance, first need to be resolved before successful clinical implementation.

Systematic Review

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Molecular mechanism and therapeutic significance of dihydromyricetin in nonalcoholic fatty liver disease

Gong H et al. • European journal of pharmacology (2022)

For NAFLD, there is currently no effective and approved medication for therapy.

For NAFLD, there is currently no effective and approved medication for therapy.
DHM has the characteristics of liver protection, antioxidation, anti-inflammatory and apoptosis-regulatory benefits, which provides a new idea for the treatment of NAFLD.
With the increasing interest in utilizing natural products to prevent and control liver diseases, our work aims to provide new ideas for the treatment of NAFLD and accelerate its translation from bench to bedside.Copyright © 2022 Elsevier B.V.

Systematic Review

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Chinese herbal medicine: Fighting SARS-CoV-2 infection on all fronts

Wang Z et al. • Journal of ethnopharmacology (2021)

As a key component of the COVID-19 treatment regimen, Chinese herbal medicines have played an irreplaceable role in the treatment of SARS-CoV-2 infection.

As a key component of the COVID-19 treatment regimen, Chinese herbal medicines have played an irreplaceable role in the treatment of SARS-CoV-2 infection.
The "Chinese protocol" has already demonstrated clear clinical importance.
The use of Chinese herbal medicines that are capable of inhibiting SARS-Cov-2 infection may help to address this immediate unmet clinical need and may be attractive to other countries that are also seeking new options for effective COVID-19 treatment.

Systematic Review

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Activation of Nrf2/HO-1 signaling: An important molecular mechanism of herbal medicine in the treatment of atherosclerosis via the protection of vascular endothelial cells from oxidative stress

Zhang Q et al. • Journal of advanced research (2021)

Our present paper provides updated information of natural agents with protective activities on ECs against oxidative stress by activating Nrf2/HO-1.

Our present paper provides updated information of natural agents with protective activities on ECs against oxidative stress by activating Nrf2/HO-1.
We hope this review will provide some directions for the further development of novel candidate drugs from natural agents for the treatment of AS and other CVDs.
Further research warranted to confirm findings

Systematic Review

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