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Dh7.5
DHM Research
Mixed evidenceHigh safety
32 peer-reviewed studies
What the evidence says
Mixed evidence
Studies are split: DHM helped in 1 of 3 cases, with the rest inconclusive or showing no benefit.
Most evidence is from high-quality meta-analyses and randomised trials published 2012–2026 with a typical study size of 80 participants.
Based on 32 studies · 1 meta-analysis · 2 RCTs · 512 total participants
Confidence
Moderate
What the studies found
1helped2unclear· 29 more without graded effect data
By outcome
Liver health
Mostly mechanism / observational8 studies
Therapeutic & clinical
Mostly mechanism / observational7 studies
Heart & blood pressure
Mostly mechanism / observational6 studies
InflammationEnhanced liver protection and alcohol metabolism · Acute use or 2-4 weeks ongoing
Mostly mechanism / observational6 studies
Glucose & metabolic
Mostly mechanism / observational5 studies
Anxiety & stress
Too few graded studies2 studies
Neuroprotection & brain aging
Too few graded studies2 studies
Longevity & aging
Too few graded studies1 study
Safety profile
Too few graded studies1 study
By the numbers
Pulled from 26 studies with measurable effects
People studied
512
typical study: 80 people
Strongest designs
3
1 pooled, 2 randomised
Showed benefit
33%
1/3 studies
How long studies ran
3+ months
1
Populations Studied
Vascular endothelial cells2
Patients with chronic kidney disease1
Patients with liver disorders and liver cancer1
Patients with renal fibrosis1
Active research area
23 studies in the last 5 years · Latest meta-analysis: 2023
201220192026
1Systematic ReviewCited 5×2025
It examines the key factors influencing its bioavailability and highlights the design and construction of various bio-based delivery systems aimed at improving its bioavailability.
Hou G et al. · Food chemistry (2025)
It examines the key factors influencing its bioavailability and highlights the design and construction of various bio-based delivery systems aimed at improving its bioavailability.
Furthermore, the paper explores the potential applications of these delivery systems.
The development of such systems can significantly enhance the stability and bioavailability of dihydromyricetin, providing a solid theoretical foundation for advancing its use in food and medicine.
2Urinary protein levelsMeta-Analysisn=372 · medium study2023
More clinical trial protocols with large sample sizes and rigorous design and in line with international norms are needed to improve the evidence quality, and the results of bioinformatics analysis remain to be confirmed by further studies.
Wang FP et al. · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (2023)
Meta-analysis showed that the Huangkui Capsules group and the losartan potassium group had no significant differences in reducing the urinary protein levels after 12(MD=19.60, 95%CI[-58.66, 97.86], P=0.62) and 24 weeks(MD=-66.00, 95%CI[-264.10, 132.11], P=0.51) of treatment.
Huangkui Capsules in combination with conventional treatment was superior to conventional treatment alone(MD=-0.55, 95%CI[-0.86,-0.23], P=0.000 6).
Huangkui Capsules combined with conventional treatment was superior to conventional treatment alone in recovering Scr(MD=-9.21, 95%CI[-15.85,-2.58], P=0.006) and BUN(MD=-1.02, 95%CI[-1.83,-0.21], P=0.01).
3Systematic ReviewCited 42×2023
This review systematically illustrates that various polyphenols, including resveratrol, chlorogenic acid, caffeic acid, dihydromyricetin, quercetin, catechins, curcumin, etc., improve metabolic disorders through direct or indirect pathways to protect the liver and fight liver cancer.
Li S et al. · Cell proliferation (2023)
This review systematically illustrates that various polyphenols, including resveratrol, chlorogenic acid, caffeic acid, dihydromyricetin, quercetin, catechins, curcumin, etc., improve metabolic disorders through direct or indirect pathways to protect the liver and fight liver cancer.
5Autophagy regulation in alcohol-related liver diseaseSystematic ReviewCited 8×2023
The regulation of autophagy in ALD by these traditional Chinese medicine extracts provides novel ideas for the treatment of the disease; however, its molecular mechanism needs to be elucidated further.
Han W et al. · PeerJ (2023)
Therefore, autophagy plays an critical role in the occurrence and development of ALD.
Some studies have shown that traditional Chinese medicine extracts improve the histological characteristics of ALD, as reflected in the improvement of oxidative stress and lipid droplet clearance, which might be achieved by inducing autophagy.
This article reviews the mechanisms of quercetin, baicalin, glycycoumarin, salvianolic acid A, resveratrol, ginsenoside rg1, and dihydromyricetin inducing autophagy and their participation in the inhibition of ALD.
6Dihydromyricetin effects in diabetes mellitus treatmentSystematic ReviewCited 18×2023
In this review, following with a brief introduction of the absorption, metabolism, distribution, and excretion characteristics of DMY, we summarized the current pharmacological developments of DMY as well as possible molecular mechanisms in the treatment of DM, aiming to push the understanding about the protective role of DMY as well as its preclinical assessment of novel application.
Wang Z et al. · Frontiers in endocrinology (2023)
A detailed summary of related signaling induced by DMY are discussed.
Hence, the mechanisms underlying the therapeutic implications of DMY in DM are still obscure.
7SIRT1 modulation in Alzheimer's diseaseSystematic ReviewCited 46×2023
The natural molecules modulating SIRT1 discussed in this review provide a potentially novel multi-mechanistic therapeutic strategy for AD.
Zhang M et al. · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (2023)
The natural molecules modulating SIRT1 discussed in this review provide a potentially novel multi-mechanistic therapeutic strategy for AD.
However, future clinical trials need to be conducted to further investigate their beneficial properties and to determine the safety and efficacy of SIRT1 natural activators against AD.
9Dihydromyricetin effects in cardiovascular diseasesSystematic ReviewCited 5×2022
The aim of this review is to provide a better understanding and quick overview for future researches of dihydromyricetin in the field of cardiovascular diseases, and more detailed and robust researches are needed for evaluation and reference.
Nie H et al. · Physiological research (2022)
In addition, DMY may play a role in cardiovascular disease by resisting oxidative stress and participating in the regulation of inflammation.
This review is the first review that summaries the applications of dihydromyricetin in cardiovascular diseases, including atherosclerosis, myocardial infarction, myocardial hypertrophy, and diabetic cardiomyopathy.
We also clarified the underlying mechanisms and signaling pathways involved in the above process.
10Dihydromyricetin application in metabolic diseasesSystematic ReviewCited 46×2022
In addition, the mechanism of DMY on these diseases was also related to the signal pathway of AMPK, PI3K/Akt, PPAR and the participation of microRNAs.
Wang Y et al. · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (2022)
In addition, the mechanism of DMY on these diseases was also related to the signal pathway of AMPK, PI3K/Akt, PPAR and the participation of microRNAs.
This review describes the mechanism of DMY in metabolic related diseases from three aspects: metabolic diseases, liver diseases, and cancers, hoping to provide some new ideas for clinical researches.
11RAS signalling inhibition for ageing and age-related healthSystematic ReviewCited 12×2022
Here, we review evidence that RAS/MAPK signalling inhibitors already in clinical use, such as trametinib, acarbose, statins, metformin and dihydromyricetin, lead to lifespan extension and to improv...
Laskovs M et al. · Disease models & mechanisms (2022)
Here, we review evidence that RAS/MAPK signalling inhibitors already in clinical use, such as trametinib, acarbose, statins, metformin and dihydromyricetin, lead to lifespan extension and to improved healthspan in a range of model systems.
These findings suggest that the repurposing of small molecule inhibitors of RAS/MAPK signalling might offer opportunities to improve health during ageing, and to delay or prevent the development of age-related disease.
However, challenges to this approach, including poor tolerance to treatment in older adults or development of drug resistance, first need to be resolved before successful clinical implementation.
12Dihydromyricetin effects in nonalcoholic fatty liver diseaseSystematic ReviewCited 9×2022
For NAFLD, there is currently no effective and approved medication for therapy.
Gong H et al. · European journal of pharmacology (2022)
For NAFLD, there is currently no effective and approved medication for therapy.
DHM has the characteristics of liver protection, antioxidation, anti-inflammatory and apoptosis-regulatory benefits, which provides a new idea for the treatment of NAFLD.
With the increasing interest in utilizing natural products to prevent and control liver diseases, our work aims to provide new ideas for the treatment of NAFLD and accelerate its translation from bench to bedside.
13Chinese herbal medicine efficacy in SARS-CoV-2 infectionSystematic ReviewCited 102×2021
As a key component of the COVID-19 treatment regimen, Chinese herbal medicines have played an irreplaceable role in the treatment of SARS-CoV-2 infection.
Wang Z et al. · Journal of ethnopharmacology (2021)
As a key component of the COVID-19 treatment regimen, Chinese herbal medicines have played an irreplaceable role in the treatment of SARS-CoV-2 infection.
The "Chinese protocol" has already demonstrated clear clinical importance.
The use of Chinese herbal medicines that are capable of inhibiting SARS-Cov-2 infection may help to address this immediate unmet clinical need and may be attractive to other countries that are also seeking new options for effective COVID-19 treatment.
14Endothelial cell protection from oxidative stress via Nrf2/HO-1 activationSystematic ReviewCited 656×2021
Our present paper provides updated information of natural agents with protective activities on ECs against oxidative stress by activating Nrf2/HO-1.
Zhang Q et al. · Journal of advanced research (2021)
Our present paper provides updated information of natural agents with protective activities on ECs against oxidative stress by activating Nrf2/HO-1.
We hope this review will provide some directions for the further development of novel candidate drugs from natural agents for the treatment of AS and other CVDs.
15Suppression of endothelial cell apoptosis in atherosclerosisSystematic ReviewCited 203×2021
Interestingly, accumulating evidence shows that natural medicines have great potential to treat atherosclerosis by inhibiting endothelial cell apoptosis.
Duan H et al. · Pharmacological research (2021)
Interestingly, accumulating evidence shows that natural medicines have great potential to treat atherosclerosis by inhibiting endothelial cell apoptosis.
16Myocardial ischemia/reperfusion injury via epigenetic regulationSystematic ReviewCited 97×2021
At present, no effective treatment is available for myocardial ischemia/reperfusion injury.
Wang K et al. · Pharmacological research (2021)
At present, no effective treatment is available for myocardial ischemia/reperfusion injury.
Emerging evidence indicates that epigenetic regulation is closely related to the pathogenesis of myocardial ischemia/reperfusion injury, indicating that epigenetics may serve as a novel therapeutic target to ameliorate or prevent ischemia/reperfusion injury.
The pharmacological mechanisms of DHM may be associated with its anti-inflammatory, anti-oxidative and apoptosis-regulatory benefits.
With the accumulating interests in utilizing natural products to target common diseases, our work aims to improve the understanding of DHM acting as a novel drug candidate for liver diseases and to accelerate its translation from bench to bedside.
Atazadegan MA et al. · Advances in experimental medicine and biology (2021)
However, to our knowledge, the effect of these natural products, including herbal supplements and functional foods on adiponectin, has not yet been fully reviewed.
The main aim of this review is to summarize the effects of nutraceuticals and herbal bioactive compounds on plasma adiponectin concentrations based on clinical studies.
19Safety and efficacy of alcohol hangover treatmentsSystematic ReviewCited 13×2021
Fifty-one products (62.2% of the 82 evaluated products) contained one or more vitamins of which the dose exceeded the corresponding daily recommended intake level.
Verster JC et al. · Addictive behaviors (2021)
No clear effect
← WorseNo effectBetter →
Fifty-one products (62.2% of the 82 evaluated products) contained one or more vitamins of which the dose exceeded the corresponding daily recommended intake level.
For 9 (28.1%) of 32 products that reported the dose of Vitamin B3 and 2 (8.0%) of 25 products that reported the dose of Vitamin B9 the corresponding tolerable upper intake level was exceeded.
Further, in many other cases the dose of other ingredients was not reported (e.g., dosages of DHM and NAC were not reported by 59% and 73% of the products containing these ingredients), and corresponding tolerable upper limits are unknown.
20Phytochemistry and biological activities of Hovenia dulcisSystematic ReviewCited 22×2021
The aim of this work is to review the whole scientific production, with special focus on the last decade, in order to update phytochemistry, biological activities, nutritional properties, toxicological aspect and regulatory classification of H. dulcis extracts for its use in the European Union.
Sferrazza G et al. · Molecules (Basel, Switzerland) (2021)
These biological properties are related to a variety of secondary metabolites synthesized by the different plant parts.
Finally, peduncles have plenty of polysaccharides which justify the use as a food supplement.
The aim of this work is to review the whole scientific production, with special focus on the last decade, in order to update phytochemistry, biological activities, nutritional properties, toxicological aspect and regulatory classification of H. dulcis extracts for its use in the European Union.