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Dihydromyricetin (Ampelopsin)
Enhances alcohol-metabolizing enzymes and protects liver cells — derived from the Japanese raisin tree used for centuries in Asia.
What the evidence says
Studies are split: DHM helped in 1 of 3 cases, with the rest inconclusive or showing no benefit.
Most evidence is from high-quality meta-analyses and randomised trials published 2012–2026 with a typical study size of 80 participants.
Based on 32 studies · 1 meta-analysis · 2 RCTs · 512 total participants
Confidence
ModerateWhat the studies found
By outcome
DHM has an evidence score of 7.5/10 — strong evidence based on 32 indexed studies, including 2 meta-analyses. Enhances alcohol-metabolizing enzymes and protects liver cells — derived from the Japanese raisin tree used for centuries in Asia.
The commonly studied dose of DHM is 300-600mg before or after drinking; 300mg daily for liver support. Research points to an estimated optimal dose around 600mg, with a minimum effective dose near 300mg. Individual response varies — start low and adjust.
Timing is flexible for DHM — consistent daily use matters more than the time of day. Dihydromyricetin (DHM, also called ampelopsin) is a flavanonol from Hovenia dulcis and Ampelopsis grossedentata that enhances alcohol dehydrogenase and aldehyde dehydrogenase activity, accelerating acetaldehyde clearance.
Soy Isoflavones
Likely helpsPlant compounds with weak estrogenic effects that support menopausal symptoms, bone health, and cardiovascular function.
Indole-3-Carbinol
Likely helpsConverts to DIM in the stomach, shifting estrogen metabolism toward favorable 2-hydroxy metabolites for hormonal balance.
Last reviewed May 2026 · evidence from 38 studies · how we score
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.
Dihydromyricetin (DHM) is a flavonoid extracted from Hovenia dulcis (Japanese raisin tree), traditionally used in Asian medicine for hangovers and liver health. Research shows DHM enhances alcohol metabolism enzymes and has hepatoprotective effects. It's gaining popularity as a natural support for those who drink alcohol and for general liver health.
Boosts alcohol-metabolizing enzymes
Protects liver cells from damage
May counteract alcohol's effects on GABA receptors
How DHM works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
300-600mg before or after drinking; 300mg daily for liver support
Loading: For alcohol occasions: 300mg before drinking, 300mg before bed
Take with food
| Form | Type |
|---|---|
| 💊Dihydromyricetin capsules or tablets | Recommended |
| 💊Hovenia dulcis extract | Alternative |
Look for standardized DHM content. Often found in 'hangover' supplement blends.
Minimum: 1 weeks
Optimal: 4 weeks
Cycling: Not required
Note: For alcohol-related use, take before drinking and again before sleep. Can also be used as ongoing liver support.
Evidence primarily from systematic reviews examining polyphenol hepatoprotective mechanisms rather than direct DHM clinical trials. Bioavailability limitations may reduce actual effectiveness. Conservative estimates given lack of specific dose-response studies.
Quicker clearance of alcohol and acetaldehyde
Reduced liver stress from alcohol
May reduce next-day symptoms
Consult doctor; may be helpful but need monitoring
May affect drug metabolism
Tip: Take with food
DHM is generally well-tolerated and considered safe for most healthy adults at recommended doses. The most commonly reported side effects are GI upset. Use caution if any of these apply to you: Known allergy or hypersensitivity to DHM or related compounds.
Alpha Lipoic Acid
Likely helpsUniversal antioxidant that works in both water and fat, supporting blood sugar control, nerve health, and cellular energy.
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