Dihydromyricetin (Ampelopsin)
Enhances alcohol-metabolizing enzymes and protects liver cells — derived from the Japanese raisin tree used for centuries in Asia.
Dihydromyricetin (DHM) is a flavonoid extracted from Hovenia dulcis (Japanese raisin tree), traditionally used in Asian medicine for hangovers and liver health. Research shows DHM enhances alcohol metabolism enzymes and has hepatoprotective effects. It's gaining popularity as a natural support for those who drink alcohol and for general liver health.
Boosts alcohol-metabolizing enzymes
Protects liver cells from damage
May counteract alcohol's effects on GABA receptors
How DHM works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
300-600mg before or after drinking; 300mg daily for liver support
Loading: For alcohol occasions: 300mg before drinking, 300mg before bed
Take with food
| Form | Type |
|---|---|
| 💊Dihydromyricetin capsules or tablets | Recommended |
| 💊Hovenia dulcis extract | Alternative |
Look for standardized DHM content. Often found in 'hangover' supplement blends.
Minimum: 1 weeks
Optimal: 4 weeks
Cycling: Not required
Note: For alcohol-related use, take before drinking and again before sleep. Can also be used as ongoing liver support.
Quicker clearance of alcohol and acetaldehyde
Reduced liver stress from alcohol
May reduce next-day symptoms
Consult doctor; may be helpful but need monitoring
May affect drug metabolism
Tip: Take with food
Top studies from 38+ peer-reviewed papers
Zhou R et al. • International journal of molecular sciences (2025)
“A deeper understanding of autophagy's regulatory networks, particularly involving these critical genes and proteins, may lead to novel therapeutic approaches for treating metabolic cardiomyopathy.”
Keshavarzian E et al. • Reviews on recent clinical trials (2023)
“This meta-analysis showed that prophylactic treatment with cardio-protective drugs, including dexrazoxane, beta blocker, and ACEI drugs in patients undergoing chemotherapy with anthracycline, have a protective effect on LVEF and prevent EF drop.”
Li S et al. • Cell proliferation (2023)
“This review systematically illustrates that various polyphenols, including resveratrol, chlorogenic acid, caffeic acid, dihydromyricetin, quercetin, catechins, curcumin, etc., improve metabolic disorders through direct or indirect pathways to protect the liver and fight liver cancer.”
Sayed AM et al. • Life sciences (2020)
“Additionally, molecular modeling simulations were applied to explore the potential binding mode of these flavonoids to SIRT1.”
Lin R et al. • Pharmacological research (2025)
“This review aims to provide a theoretical framework and translational guidance for developing HF-targeted therapeutic strategies based on Sirtuin-mediated macrophage polarization, as well as for th...”
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