Diosmin Research

Daflon 500 mg and venous leg ulcer: new results from a meta-analysis.

Smith PC · Angiology (2005)

[Common sense of diosmin administration in combined treatment of hemorrhoids].

Bashankaev BN, Wexner SD, Arkharov AV · Khirurgiia (Mosk) (2018)

Efficacy of micronized purified flavonoid fraction (Daflon®) on improving individual symptoms, signs and quality of life in patients with chronic venous disease: a systematic review and meta-analysis of randomized double-blind placebo-controlled trials.

Kakkos SK, Nicolaides AN · Int Angiol (2018)

Venous leg ulcer: a meta-analysis of adjunctive therapy with micronized purified flavonoid fraction.

Coleridge-Smith P, Lok C, Ramelet AA · Eur J Vasc Endovasc Surg (2005)

Micronized diosmin (Detralex) for vein-related trophic ulcers: European experience.

Savel'ev VS, Pokrovskiĭ AV, Sapelkin SV, Bogachev VIu, Bogdanets LI, Zolotukhin IA · Angiol Sosud Khir (2006)

Micronized Purified Flavonoid Fraction in Hemorrhoid Disease: A Systematic Review and Meta-Analysis.

Sheikh P, Lohsiriwat V, Shelygin Y · Adv Ther (2020)

The Effects of Different Dosages on Micronized Purified Flavonoid Fraction's Treatment of Lower Limb Chronic Venous Disease: A Meta-Analysis

In plain English: This meta-analysis examined the effects of Diosmin.

Cui HJ, Wu YF. · Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists (2026)

A Randomized Controlled Trial Evaluating the Effects of Diosmin in the Treatment of Radicular Pain.

Wang Y, Fang X, Ye L, Li Y, Shi H, Cao Y · Biomed Res Int (2017)

Advantage of a micronized flavonoidic fraction (Daflon 500 mg) in comparison with a nonmicronized diosmin.

Amato C · Angiology (1994)

Efficacy of Diosmin in Reducing Lower-Extremity Swelling and Pain After Total Knee Arthroplasty: A Randomized, Controlled Multicenter Trial.

Wang Q, Jin Q, Cai L, Zhao C, Feng P, Jia J · J Bone Joint Surg Am (2024)

Efficacy of a Low-Dose Diosmin Therapy on Improving Symptoms and Quality of Life in Patients with Chronic Venous Disease: Randomized, Double-Blind, Placebo-Controlled Trial.

Serra R, Ielapi N, Bitonti A, Candido S, Fregola S, Gallo A · Nutrients (2021)

[Randomized study of the use of synthetic diosmin in premenstrual and vascular dysplastic mastodynia].

Meggiorini ML, Cascialli GL, Luciani S, Nusiner MP, Pozzi V · Minerva Ginecol (1990)

[Non-drug methods of treatment of post-thrombophlebitic syndrome].

Kulchitskaya DB, Fesyun AD, Apkhanova TV, Konchugova TV, Yakovlev MY, Gushchina NV · Vopr Kurortol Fizioter Lech Fiz Kult (2022)

A randomised controlled trial of micronised purified flavonoid fraction vs placebo in patients with chronic venous disease.

Danielsson G, Jungbeck C, Peterson K, Norgren L · Eur J Vasc Endovasc Surg (2002)

Efficacy of a 6-month treatment with Daflon 500 mg in patients with venous leg ulcers associated with chronic venous insufficiency.

Roztocil K, Stvrtinová V, Strejcek J · Int Angiol (2003)

Therapeutic efficacy of flavonoids in oedema following reperfusion on acutely ischaemic legs.

Filis KA, Georgopoulos SE, Papas SC, Votteas V, Bastounis EA · Int Angiol (1999)

[Evaluation of clinical efficacy of a venotonic drug: lessons of a therapeutic trial with hemisynthesis diosmin in "heavy legs syndrome"].

Carpentier PH, Mathieu M · J Mal Vasc (1998)

Efficacy and Safety of Daflon® in the Treatment of Idiopathic Epistaxis.

Attia TM · Am J Rhinol Allergy (2019)

Effectiveness and safety of a product containing diosmin, coumarin, and arbutin (Linfadren®) in addition to complex decongestive therapy on management of breast cancer-related lymphedema.

Cacchio A, Prencipe R, Bertone M, De Benedictis L, Taglieri L, D'Elia E · Support Care Cancer (2019)

Effectiveness and safety of a mixture of diosmin, coumarin and arbutin (Linfadren®) in addition to conventional treatment in the management of patients with post-trauma/surgery persistent hand edema: a randomized controlled trial.

Cacchio A, Di Carlo G, Vincenza C, De Blasis E · Clin Rehabil (2019)