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4 peer-reviewed studies
What the evidence says
Most Diosmin studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 2005–2020.
Based on 4 studies · 3 meta-analyses
Confidence
HighBy outcome
Newest study from 2020 · Latest meta-analysis: 2020
A Cochrane review (56 studies, 7,690 participants) found moderate-certainty evidence that phlebotonics (incl. diosmin/MPFF) probably reduce edema in chronic venous insufficiency.
Martinez-Zapata MJ et al. · Cochrane Database Syst Rev (2020)
A meta-analysis (7 RCTs, 1,692 patients) concluded micronized purified flavonoid fraction (Daflon/MPFF) is highly effective for chronic venous disease leg symptoms, edema, and quality of life.
Kakkos SK et al. · Int Angiol (2018)
A Cochrane meta-analysis found phlebotonics (including diosmin/MPFF) beneficial for hemorrhoid symptoms.
Perera N et al. · Cochrane Database Syst Rev (2012)
A review summarized the venotonic mechanisms and clinical use of Daflon (MPFF) in chronic venous insufficiency.
Bergan JJ et al. · Angiology (2005)