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Diosmin / MPFF (Micronized Purified Flavonoid Fraction)
A citrus flavonoid (usually as micronized diosmin+hesperidin, 'MPFF'/Daflon) with some of the strongest venoactive evidence — meta-analyses support reduced leg edema/symptoms in chronic venous insufficiency and relief of hemorrhoid symptoms.
What the evidence says
Diosmin doesn't have enough studies with structured effect-size data yet to pool a verdict. Browse the studies below for individual findings.
Most evidence is from high-quality meta-analyses and randomised trials published 1978–2026 with a typical study size of 7,690 participants.
Based on 78 studies · 9 meta-analyses · 54 RCTs · 7,690 total participants
Confidence
High confidenceBy outcome
Scores 7/Strong because multiple meta-analyses, including Cochrane reviews, show MPFF/diosmin reduces leg edema and venous symptoms and relieves hemorrhoids, though most strong evidence is for the MPFF combination and some trials are industry-supported.
58 randomised trials
82% were about Diosmin in an audit of 50 of them
Every randomised or controlled trial of Diosmin indexed in PubMed, not a hand-picked subset. Meta-analyses and systematic reviews are deliberately excluded from this count: most of them cover many compounds at once, so counting them would inflate it.
PubMed · as of Sep 2026
13 trials ongoing or recruiting · 26 completed on ClinicalTrials.gov
3 of the completed trials have posted results
Registered trials show research momentum for Diosmin, not proof of effect — a registration is a plan, and posted results are sponsor-reported, not peer-reviewed. They are never counted toward the evidence rating above.
Browse these trials on ClinicalTrials.govClinicalTrials.gov · as of Oct 2026
Under EU law (Reg. 1924/2006), EFSA reviews whether a specific health claim for Diosmin meets the evidence standard. These are independent regulatory decisions on claims — not studies, and never counted toward the evidence score above.
“Not authorised” means the specific claim wording did not meet the EU’s evidence standard — often a matter of dossier or phrasing, not proof of no effect. EFSA judges marketing claims and is kept separate from our study-based evidence score.
Source: EU Register of nutrition and health claims (European Commission / EFSA) · register snapshot Feb 2013
Diosmin is a citrus-derived flavonoid, most studied as the micronized purified flavonoid fraction (MPFF, 90% diosmin + 10% hesperidin; brand Daflon).
It is the best-evidenced venoactive agent: meta-analyses — including Cochrane reviews of phlebotonics — show it reduces leg edema and improves venous symptoms and quality of life in chronic venous insufficiency, and it relieves hemorrhoid symptoms.
It works by improving venous tone, lymphatic drainage, capillary resistance, and by reducing inflammatory leukocyte–endothelium interactions. Two honest caveats: most high-quality evidence is for the MPFF combination (not plain diosmin), and several MPFF trials are industry-supported.
It relieves symptoms and is an adjunct to compression therapy, not a cure for structural venous disease.
Increases venous tone and reduces venous distensibility, improving venous return.
Improves lymphatic drainage and capillary resistance, reducing edema.
Reduces leukocyte adhesion and inflammatory mediators at the vein wall.
How Diosmin works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
Caution. Ask a clinician before starting it for a nonessential use, rather than starting it yourself. In pregnancy, a small late-pregnancy study and a large French cohort reported no harm signal, but that is too little to establish safety, and the licensed MPFF product label advises avoiding it as a precaution. In breastfeeding, excretion into milk is unknown. Neither gap shows harm. Breastfeeding takes priority over taking it.
Few documented drug interactions; generally well tolerated. This possible interaction has not been individually evaluated for this supplement; its likelihood and severity are unknown. If you take an anticoagulant or antiplatelet medicine, ask a pharmacist or prescriber before using this product. Do not stop or change prescribed medicines based on this notice.
Tip: Take with food
Tip: Reduce dose
Diosmin has an evidence score of 7/10 — strong evidence based on 78 indexed studies, including 4 meta-analyses. A citrus flavonoid (usually as micronized diosmin+hesperidin, 'MPFF'/Daflon) with some of the strongest venoactive evidence — meta-analyses support reduced leg edema/symptoms in chronic venous insufficiency and relief of hemorrhoid symptoms. Representative study: PMID 33141449.
The commonly studied dose of Diosmin is 1000mg MPFF daily (900mg diosmin + 100mg hesperidin); acute hemorrhoid protocols use higher short-term doses (a typical label dose, no cited trial states the dose it used). Individual needs vary — start at the lower end of the range and adjust based on how you respond.
The best time to take Diosmin is with meals. Take it with food. Taken with meals; micronized form improves absorption.
Diosmin is generally well-tolerated and considered safe for most healthy adults at recommended doses. Reported side effects include mild GI upset, headache. How often they occur is not established for all of them. Use caution if any of these apply to you: Pregnancy and breastfeeding: avoid starting it yourself for a nonessential use, pending clinician advice. This is a precaution, not a demonstrated contraindication (limited human data in pregnancy, excretion into milk unknown).; Allergy to citrus flavonoids.
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Reviewed by Dr. Baher Al Hakim · Last reviewed June 2026 · evidence from 78 studies · how we score · editorial policy
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.
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