Dq8.5

Dong Quai Research

39 peer-reviewed studies · Evidence score: 8.5/10

Treatment of chronic urticaria with traditional Chinese medicine: A systematic review, meta-analysis, and medication regularity

Chen R et al. • Medicine (2025)

TCM has great advantages in the treatment of CU, can effectively improve the symptoms, the curative effect is stable and safe, but there are still some deficiencies in the standardization of curative effect evaluation.

TCM has great advantages in the treatment of CU, can effectively improve the symptoms, the curative effect is stable and safe, but there are still some deficiencies in the standardization of curative effect evaluation.
Further research warranted to confirm findings

Meta-Analysisn=1,192

DOI

Efficacy and safety of Xuebijing injection (a Chinese patent) for sepsis: A meta-analysis of randomized controlled trials

Li C et al. • Journal of ethnopharmacology (2018)

This study suggested that supplementation with XBJ in addition to regular treatment may improve the 28-day mortality rate, APACHE Ⅱ scores, WBC count and body temperature of sepsis patients without serious adverse events, but it may not reduce mortality during treatment, revealing a specific, remote effect of traditional Chinese medicine.

Very low-quality evidence showed that WBC count improved with combined medication at high dosages (one study included, 40/1144, MD -8.00, 95% CI -10.18 to -5.82), but there was no reduction at moderate dosages (230/1144, MD -2.38, 95% CI -5.01 to 0.25; P = 0.08, I2 = 70%).
However, moderate-quality evidence indicated positive results with low dosages (142/1144, MD -2.88, 95% CI -3.79 to -1.96; P < 0.000 01, I2 = 0%).
Low-quality evidence showed no risk difference for mortality during treatment (210/1144, RR 0.65, 95% CI 0.36-1.17; P = 0.15, I2 = 0%).

Meta-Analysisn=1,144

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Z-Ligustilide: A Potential Therapeutic Agent for Atherosclerosis Complicating Cerebrovascular Disease

Shen L et al. • Biomolecules (2024)

This paper aims to provide a basis for subsequent studies of Z-LIG in the prevention and treatment of AS and its cerebrovascular complications and, thus, to promote the development of interventional drugs for AS.

Then, we reviewed Z-LIG's intervention and therapeutic mechanisms on AS and its cerebrovascular complications.
The mechanisms of Z-LIG intervention in AS include improving lipid metabolism, antioxidant and anti-inflammatory effects, protecting vascular endothelium, and inhibiting vascular endothelial fibrosis, pathological thickening, and plaque calcification.
This paper aims to provide a basis for subsequent studies of Z-LIG in the prevention and treatment of AS and its cerebrovascular complications and, thus, to promote the development of interventional drugs for AS.

Systematic Review

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The angelica Polysaccharide: a review of phytochemistry, pharmacology and beneficial effects on systemic diseases

Shen J et al. • International immunopharmacology (2024)

However, different extraction methods and extraction sites greatly affect the efficacy of APS.

However, different extraction methods and extraction sites greatly affect the efficacy of APS.
In recent years, with the emerging of new technologies, there are more and more studies on the combined application and structural modification of APS.

Systematic Review

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Activation of Nrf2/HO-1 signaling: An important molecular mechanism of herbal medicine in the treatment of atherosclerosis via the protection of vascular endothelial cells from oxidative stress

Zhang Q et al. • Journal of advanced research (2021)

Our present paper provides updated information of natural agents with protective activities on ECs against oxidative stress by activating Nrf2/HO-1.

Our present paper provides updated information of natural agents with protective activities on ECs against oxidative stress by activating Nrf2/HO-1.
We hope this review will provide some directions for the further development of novel candidate drugs from natural agents for the treatment of AS and other CVDs.
Further research warranted to confirm findings

Systematic Review

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Medicine-food herb: Angelica sinensis, a potential therapeutic hope for Alzheimer's disease and related complications

Long Y et al. • Food & function (2022)

This review will provide further support for the research on AD and the application of medicine-food herb AS in a healthy lifestyle in the future.

The role of dietary supplement components in AS for AD intervention is summarized, including vitamin B12, folic acid, arginine, and oleic acid, which can improve the symptoms of AD.
Besides, this review focuses on the safety and toxicity evaluation of AS, which provides a basis for its application.
This review will provide further support for the research on AD and the application of medicine-food herb AS in a healthy lifestyle in the future.

Systematic Review

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Overview of therapeutic potentiality of Angelica sinensis for ischemic stroke

Han Y et al. • Phytomedicine : international journal of phytotherapy and phytopharmacology (2021)

A. sinensis is a key agent for ischemic stroke treatment, and worth deeply excavating its therapeutic potentiality with the aid of pharmacological network, computer-aided drug design, artificial intelligence, big data and multi-scale modelling techniques.

A. sinensis is a key agent for ischemic stroke treatment, and worth deeply excavating its therapeutic potentiality with the aid of pharmacological network, computer-aided drug design, artificial intelligence, big data and multi-scale modelling techniques.
Further research warranted to confirm findings

Systematic Review

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Immunomodulation of Chinese Herbal Medicines on NK cell populations for cancer therapy: A systematic review

Liu H et al. • Journal of ethnopharmacology (2021)

Thus exploring the roles of NK cells in adjuvant therapy against cancer is confirmed to be beneficial to explore the underlying relationship between immunomodulation and quality of life.

Evidence-based functions of CHMs against cancer could be summarized as: (1) enhancement of NK cells activity or relative percentage; (2) prevention of tumor growth and metastasis; (3) relief on side-effects or complications of therapeutic strategies (i.e. chemotherapy, radiotherapy and resection).
Further research warranted to confirm findings

Systematic Review

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Extraction, structure, pharmacological activities and drug carrier applications of Angelica sinensis polysaccharide

Nai J et al. • International journal of biological macromolecules (2021)

ASP has a variety of pharmacological activities, including hematopoietic activity, promoting immunity, antitumor, anti-inflammatory, antioxidant, anti-aging, anti-virus, liver protection, and so on.

ASP has a variety of pharmacological activities, including hematopoietic activity, promoting immunity, antitumor, anti-inflammatory, antioxidant, anti-aging, anti-virus, liver protection, and so on.
As a kind of natural polysaccharide, ASP has potential application as drug carriers.

Systematic Review

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Angelica sinensis: A Comprehensive Review of Its Pharmacological Properties and Clinical Applications

Wei WL et al. • Frontiers in Pharmacology (2021)

Angelica sinensis demonstrates anti-inflammatory, hematopoietic, and analgesic properties with clinical relevance.

Hematopoietic effects support traditional use for blood deficiency conditions
Anti-inflammatory activity comparable to NSAIDs in preclinical models
Clinical evidence strongest for menstrual disorders when used in combination formulas

Systematic Review

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A review of traditional Chinese medicine for treatment of glioblastoma

Wang J et al. • Bioscience trends (2020)

Hence, this multi-target, multi-level pathway may bring on a new dawn for the treatment of glioblastoma.

Although the current treatment is multimodal, including surgical resection, radiotherapy, and chemotherapy, it does not significantly improve survival time.
Hence, this article systematically reviews experimental research progress of some traditional Chinese medicine in treatment of glioblastoma from two aspects: strengthening vital qi and eliminating pathogenic qi.
Among, strengthening vital qi medicine includes panax ginseng, licorice, lycium barbarum, angelica sinensis; eliminating pathogenic medicine includes salvia miltiorrhiza bunge, scutellaria baicalensis, coptis rhizoma, thunder god vine, and sophora flavescens.

Systematic Review

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Z-ligustilide: A review of its pharmacokinetics and pharmacology

Xie Q et al. • Phytotherapy research : PTR (2020)

This review intends to provide a comprehensive overview of the pharmacokinetics and pharmacology of Z-ligustilide in recent years, with a focus on its biological properties and mechanisms, which is of great significance for Chinese medicine.

New evidence suggests that Z-ligustilide has a wide range of pharmacological properties, including anticancer, antiinflammatory, anti-oxidant as well as neuroprotective activities and so on.
The literature discussed is derived from readily accessible papers spanning the early 1970s to the end of March 2019.
Information were collected from journals, books, and online searches (Google Scholar, PubMed, Science Direct, Science Citation Index Finder, Springer link, and CNKI).

Systematic Review

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The structures and biological functions of polysaccharides from traditional Chinese herbs

Zeng P et al. • Progress in molecular biology and translational science (2019)

This review provides a comprehensive summary of the latest polysaccharide extraction methods and the strategies used for monosaccharide compositional analysis plus polysaccharide structural charact...

This review provides a comprehensive summary of the latest polysaccharide extraction methods and the strategies used for monosaccharide compositional analysis plus polysaccharide structural characterization.
Further research warranted to confirm findings

Systematic Review

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Traditional Chinese herbal medicine in treating amenorrhea caused by antipsychotic drugs: Meta-analysis and systematic review

Liu L et al. • Journal of ethnopharmacology (2022)

More research is needed to better understand different aspects of Chinese herbal medicine use in treatment of this particular medical condition.

The overall effectiveness for treatment amenorrhea caused by antipsychotic drugs using traditional Chinese herbal medicine was 0.91, with 95% confidence interval of 0.89-0.93.
Further research warranted to confirm findings

Meta-Analysisn=18

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The Role of Th17/Treg Axis in the Traditional Chinese Medicine Intervention on Immune-Mediated Inflammatory Diseases: A Systematic Review

Xu YY et al. • The American journal of Chinese medicine (2020)

Further research elucidates the immune-modulating mechanisms on Th17/Treg axis by TCM might provide a broader insight for the treatment of IMID.

Moreover, there were nine active ingredients (including Oxymatrine, Baicalin, Triptolide, Paeoniflorin, Sinomenine, Celastrol, Emodin, Diosgenin and Chlorogenic acid) originating from TCM reported to have an immunological regulation effect on the Th17/Treg axis.
The highlight of this systematic review is to reveal the pharmacological basis of TCM treating IMID and is helpful for supporting future pharmacologic-driven studies.
Further research elucidates the immune-modulating mechanisms on Th17/Treg axis by TCM might provide a broader insight for the treatment of IMID.

Systematic Review

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Angelica sinensis in China-A review of botanical profile, ethnopharmacology, phytochemistry and chemical analysis

Wei WL et al. • Journal of ethnopharmacology (2016)

Within the published scientific literature are numerous reports regarding analytical methods that use various chromatographic and spectrophotometric technologies to monitor various types of components with different physicochemical properties simultaneously.

Within the published scientific literature are numerous reports regarding analytical methods that use various chromatographic and spectrophotometric technologies to monitor various types of components with different physicochemical properties simultaneously.
Compounds isolated from A. sinensis are abundant sources of chemical diversity, from which we can discover active molecules.
Thus, more studies on the pharmacological mechanisms of the predominant active compounds of A. sinensis are needed.

Systematic Review

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Calycosin orchestrates the functions of Danggui Buxue Tang, a Chinese herbal decoction composing of Astragali Radix and Angelica Sinensis Radix: An evaluation by using calycosin-knock out herbal extract

Gong AG et al. • Journal of ethnopharmacology (2015)

Our results suggest that calycosin is a bioactive chemical in DBT decoction, and which could play a key linker in orchestrating multi-components of DBT as to achieve maximal functions.

Our results suggest that calycosin is a bioactive chemical in DBT decoction, and which could play a key linker in orchestrating multi-components of DBT as to achieve maximal functions.
These discoveries should be invaluable in drug development and in investigating the modernization of traditional Chinese medicine from a new perspective.
Further research warranted to confirm findings

Systematic Review

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Warfarin interactions with medicinal herbs

Milić N et al. • Natural product communications (2014)

The health professionals who are involved in treating the patients are expected to be fully informed about the interactions between warfarin and medicinal herbs in order to minimize the health risks of the patients.

Some of the interactions between warfarin and medicinal herbs have been well assessed proving that they are closely-dependent.
The health professionals who are involved in treating the patients are expected to be fully informed about the interactions between warfarin and medicinal herbs in order to minimize the health risks of the patients.
Further research warranted to confirm findings

Systematic Review

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Phytochemical and pharmacological studies on Radix Angelica sinensis

Chen XP et al. • Chinese journal of natural medicines (2013)

Based on recent animal studies and clinical trials, RAS has been used in the treatment of gynecologic diseases, cardio-cerebrovascular disease, nervous system diseases, and nephrotic syndrome.

Based on recent animal studies and clinical trials, RAS has been used in the treatment of gynecologic diseases, cardio-cerebrovascular disease, nervous system diseases, and nephrotic syndrome.
In this review, the recent phytochemical and pharmacological studies, drug-drug interactions, clinical applications, and toxicity of RAS are summarized.

Systematic Review

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Polyphenols and neuroprotection against ischemia and neurodegeneration

Lin B • Mini reviews in medicinal chemistry (2011)

Pharmacology of the 7 herbs and their major relative polyphenols is depicted in the article.

Other 4 medical plants: astragali, ligusticum wallichii, angelica sinensis and carthamus tinctorius (saffron) have been the major medicines to treat ischemia for hundreds of years in China, Korea and Japan.
Our recent experimental studies demonstrated the neuroprotective efficacy of the combination of these phyotmedicines on mitigating brain infarction and global ischemia as well as preventing the neurodegeneration following ischemia.
Owing to their multi-function, including improving cerebral blood circulation, they therefore have the potential to alleviate the symptoms of degenerative diseases, Alzheimer's disease (AD) and Parkinson's disease (PD).

Systematic Review

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