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Natural Eggshell Membrane (NEM)
An eggshell-derived membrane (collagen, elastin, glycosaminoglycans, hyaluronic acid) with small but positive RCTs and a meta-analysis for reducing joint pain and stiffness in knee osteoarthritis — though most trials are single-manufacturer.
What the evidence says
Most Eggshell Membrane studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from medium-quality meta-analyses and randomised trials published 2009–2024 with a typical study size of 67 participants.
Based on 5 studies · 1 meta-analysis · 4 RCTs · 277 total participants
Confidence
ModerateBy outcome
Eggshell Membrane has an evidence score of 4.3/10 — emerging evidence based on 5 indexed studies, including 1 meta-analysis. An eggshell-derived membrane (collagen, elastin, glycosaminoglycans, hyaluronic acid) with small but positive RCTs and a meta-analysis for reducing joint pain and stiffness in knee osteoarthritis — though most trials are single-manufacturer. Representative study: PMID 39203777.
The commonly studied dose of Eggshell Membrane is 500mg natural eggshell membrane daily. Individual needs vary — start at the lower end of the range and adjust based on how you respond.
See full supplement plans that include Eggshell Membrane.
Explore: Best supplements for Body Health
Last reviewed June 2026 · evidence from 5 studies · how we score
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.
Natural eggshell membrane (NEM) is the thin membrane between the eggshell and egg white, rich in collagen, elastin, glycosaminoglycans, and hyaluronic acid. Small randomized trials and a meta-analysis show it reduces joint pain and stiffness in knee osteoarthritis, often within 7-30 days, at a low 500mg daily dose. The honest caveat: most trials are small and conducted on a single branded ingredient (NEM/Ovomet), so independent replication is limited. It's well tolerated (egg allergy aside).
Supplies collagen, elastin, glycosaminoglycans, and hyaluronic acid for joint tissue.
May reduce joint inflammatory cytokines.
How Eggshell Membrane works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
500mg natural eggshell membrane daily
Can be taken without food
| Form | Type |
|---|---|
| 💊Natural eggshell membrane (500mg) | Recommended |
| 💊NEM | Alternative |
| 💊Ovomet | Alternative |
Most trials use a single branded ingredient.
Minimum: 1 weeks
Optimal: 8 weeks
Cycling: Not required
Note: 500mg once daily.
Dose-response data unavailable. The current published research for Eggshell Membrane does not provide sufficient dose-specific outcome data to generate reliable dose-response curves.
Refer to the Dosage & Timing section above for recommended dose ranges based on available evidence.
Eases joint pain and stiffness.
Benefit often within 7-30 days.
Avoid — derived from eggshell.
No significant documented drug interactions.
Tip: Avoid if egg-allergic
Tip: Take with food
Timing is flexible for Eggshell Membrane — consistent daily use matters more than the time of day. Once daily; timing not critical.
Eggshell Membrane is generally well-tolerated and considered safe for most healthy adults at recommended doses. The most commonly reported side effects are allergic reaction (egg), mild GI upset. Use caution if any of these apply to you: Egg allergy; Pregnancy/breastfeeding (limited data).
Hydrolyzed peptides that rebuild skin elasticity, reduce joint pain, and strengthen bone density — results build over 8-12 weeks.
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