Palmitoylethanolamide
Naturally occurring fatty acid that supports pain relief and reduces inflammation through the endocannabinoid system.
PEA is a fatty acid amide naturally produced by the body that acts on the endocannabinoid system without being a cannabinoid itself. It has been studied extensively in Europe for chronic pain, inflammation, and neuroprotection. Works through multiple pathways to reduce pain signaling and inflammation, making it a promising natural option for pain management.
Activates nuclear receptors that reduce inflammation
Calms overactive immune cells
Supports the body's endocannabinoid system
How PEA works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
600-1200mg
Take with food
| Form | Type |
|---|---|
| 💊Micronized or ultra-micronized PEA | Recommended |
| 🧪Standard PEA powder | Alternative |
| 💊Levagen+ (cold-water dispersible) | Alternative |
Standard PEA has poor absorption. Micronized forms are much better absorbed.
Minimum: 4 weeks
Optimal: 8 weeks
Cycling: Not required
Note: Micronized forms absorb better. Split dosing maintains more consistent levels.
Significant decrease in chronic pain
Lower inflammatory markers
May protect nerve cells
Insufficient data; consult doctor
Generally safe with medications
Tip: Take with food
Both reduce inflammation through different pathways
Enhanced natural pain and inflammation relief
PEA is a fatty acid amide; omega-3s support similar pathways
Comprehensive anti-inflammatory support
Both reduce mast cell activity
Synergistic anti-inflammatory and mast cell stabilization
Top studies from 39+ peer-reviewed papers
Schweiger V et al. • Nutrients (2024)
“Overall, these results confirm the clinically relevant and time-depended pain-relieving effect of micron-size PEA and therefore the advantage of an extended treatment, especially in patient with incomplete pain management.”
Lang-Illievich K et al. • Nutrients (2023)
“Further study is warranted to determine the optimal dosing and administration parameters of PEA for analgesic effects in the context of chronic pain.”
Bahji A et al. • Journal of psychopharmacology (Oxford, England) (2025)
“This study underscores the efficacy and tolerability of several pharmacotherapies in managing agitation among children and adults with ASD or ID.”
Viña I et al. • Nutrition reviews (2025)
“This meta-analysis confirmed that PEA effectively reduces pain and enhances quality of life, with significant benefits observed within 4-6 weeks of treatment.”
Yang TK et al. • Clinical & experimental ophthalmology (2025)
“This study revealed PEA as a promising agent for long-term IOP control in NTG patients, suggesting potential use as primary or adjunctive therapy.”
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