Fis8.0

Fisetin Research

39 peer-reviewed studies · Evidence score: 8/10

Therapeutic potential of flavonoids in neuroprotection: brain and spinal cord injury focus

Faysal M et al. • Naunyn-Schmiedeberg's archives of pharmacology (2025)

The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Flavonoids can enhance injury healing, reduce lesion size, and enhance synaptic plasticity and neurogenesis.
The full potential of flavonoids lies in their bioavailability, dose, and administration methods, but there are still challenges to overcome.
This review explores flavonoid-induced neuroprotection, its clinical implications, future research opportunities, and molecular mechanisms, highlighting the potential for innovative CNS injury therapies and improved patient health outcomes.

Systematic Review

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The Role and Molecular Pathways of SIRT6 in Senescence and Age-related Diseases

Lu Y et al. • Advanced biology (2025)

Moreover, recent advancements in SIRT6-regulated compounds (e.g., C3G, BZBS, Fisetin, FNDC5, Lycorine hydrochloride, and Ergothioneine) are discussed as potential therapeutic agents for these mediated diseases.

Furthermore, SIRT6 promotes autophagy, slowing cellular senescence via the modulation of various signaling pathways, including AMPK, IGF-Akt-mTOR, H133Y, IL-1β, and mitochondrial autophagy-related proteins.
Finally, SIRT6 regulates multiple signaling pathways, such asNF-κB, FOXO, and AMPK, to counteract the aging process.
Moreover, recent advancements in SIRT6-regulated compounds (e.g., C3G, BZBS, Fisetin, FNDC5, Lycorine hydrochloride, and Ergothioneine) are discussed as potential therapeutic agents for these mediated diseases.

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The antihypertensive potential of flavonoids from Chinese Herbal Medicine: A review

Cao Y et al. • Pharmacological research (2021)

So the synergistic effects of flavonoids with other drugs, pharmacokinetic studies, clinical trials and the safety of flavonoids are also incorporated in the discussion.

So the synergistic effects of flavonoids with other drugs, pharmacokinetic studies, clinical trials and the safety of flavonoids are also incorporated in the discussion.
It is believed that more breakthrough studies are needed.
Overall, this review may shed some new light on the explicit recognition of the mechanisms of anti-hypertension actions of flavonoids, pointing out the limitations of relevant research at the current stage and the aspects that should be strengthened in future researches.

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Supplement and nutraceutical therapy in traumatic brain injury

Lucke-Wold B et al. • Nutritional neuroscience (2025)

Nutraceuticals and supplements show promising potential in the management of TBI.Trial registration: ClinicalTrials.gov identifier: NCT01814527.Trial registration: ClinicalTrials.gov identifier: NCT03032302.

Nutraceuticals and supplements show promising potential in the management of TBI.Trial registration: ClinicalTrials.gov identifier: NCT01814527.Trial registration: ClinicalTrials.gov identifier: NCT03032302.
Further research warranted to confirm findings

Systematic Review

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Polyphenols in the Prevention and Treatment of Colorectal Cancer: A Systematic Review of Clinical Evidence

López-Gómez L et al. • Nutrients (2024)

In summary, although certain polyphenols appear to exert some effect, their role in the prevention or treatment of CRC is inconclusive, and more clinical studies under more controlled conditions are needed.

Curcumin demonstrated promise in various trials, mainly decreasing inflammatory cytokines, though results varied, and it did not lower intestinal adenomas or improve outcomes after chemotherapy.
Neither epigallocatechin gallate nor artepillin C reduced the incidence of adenomas.
Finally, fisetin seemed to improve the inflammatory status of patients under chemotherapy (5-fluorouracil).

Systematic Reviewn=100

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Nanocarriers for natural polyphenol senotherapeutics

Joma N et al. • Aging cell (2024)

Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.

Addressing challenges linked to nanocarriers, we present examples of senotherapeutic delivery to various cell types, both with and without nanocarriers.
Finally, continued research and development of senolytic agents and nanocarriers are encouraged to reduce the undesirable effects of senescence on different cell types and organs.
This review underscores the need for establishing reliable sets of senescence biomarkers that could assist in evaluating the effectiveness of current and future senotherapeutic candidates and nanocarriers.

Systematic Review

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Selected Flavonols in Breast and Gynecological Cancer: A Systematic Review

Wendlocha D et al. • Nutrients (2023)

In the future, these compounds may find applications in the prevention and treatment of gynecological cancers and breast cancer, but this requires further, more advanced research.

The consumption of foods that are rich in phenolic compounds has chemopreventive effects on many cancers, including breast cancer, ovarian cancer, and endometrial cancer.
A wide spectrum of their health-promoting properties such as antioxidant, anti-inflammatory, and anticancer activities, has been demonstrated.
This paper analyzes the mechanisms of the anticancer action of selected common flavonols, including kemferol, myricetin, quercetin, fisetin, galangin, isorhamnetin, and morin, in preclinical studies, with particular emphasis on in vitro studies in gynecological cancers and breast cancer.

Systematic Review

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Natural Phytochemicals as SIRT Activators-Focus on Potential Biochemical Mechanisms

Wiciński M et al. • Nutrients (2023)

This review aims to summarize recent findings on the properties of phytochemicals in the modulation of sirtuin activity, with a particular focus on biochemical aspects.

Fisetin, through SIRT1 regulation, modifies lipid metabolism and anti-inflammatory processes.
Berberine has a wide spectrum of effects and a significant impact on SIRT1 signaling pathways.
Finally, kaempferol triggers anti-inflammatory and antioxidant effects through SIRT1 induction.

Systematic Review

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Fisetin-In Search of Better Bioavailability-From Macro to Nano Modifications: A Review

Szymczak J et al. • International journal of molecular sciences (2023)

An open question remains as to which nanocarrier should be chosen to meet the abovementioned requirements and be able to enhance fisetin's therapeutic potential to treat a particular disease.

Such molecules include fisetin, found in strawberries, and have shown great promise in treating Alzheimer's disease and cancer.
Unfortunately, because of their limited water solubility, low absorption, and poor bioavailability, the assistance of nanotechnology is required to allow them to fulfil their potential fully.
Here, we provide evidence that nanodelivery methods and structure modifications can improve fisetin bioavailability, which is linked to improvements in therapeutic efficacy.

Systematic Review

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Kaempferol, Myricetin and Fisetin in Prostate and Bladder Cancer: A Systematic Review of the Literature

Crocetto F et al. • Nutrients (2021)

In conclusion, the available evidence supports the potential use of these flavonols in prostate and bladder cancer, with a low expected toxicity, thus providing the rationale for clinical trials that explore dosing, settings for clinical use as well as their use in combination with other pharmacological and non-pharmacological interventions.

Furthermore, a higher dietary intake of flavonols was associated with a lower risk of both bladder and prostate cancer in epidemiological studies.
In this systematic review, we gathered all available evidence supporting the anti-cancer potential of selected flavonols (kaempferol, fisetin and myricetin) against bladder and prostate cancer.
Further research warranted to confirm findings

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Anticancer Potential of Selected Flavonols: Fisetin, Kaempferol, and Quercetin on Head and Neck Cancers

Kubina R et al. • Nutrients (2021)

Moreover, an attempt was made to collect the majority of substantive studies on bioactive potential of the selected flavonols, especially with regard to modulation of a range of signal transduction pathways that participate in cancer development.

Special attention was paid to selected flavonols: fisetin, kaempferol, and quercetin in preclinical and in vitro studies.
Study results prove antiproliferative and proapoptotic properties of flavonols with regard to head and neck cancer.
However, few study papers evaluate specific activities during various processes associated with cancer progression.

Systematic Review

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Fisetin reduces frailty in old mice

Xu M et al. • Nature Medicine (2018)

Senolytic treatment reduced physical dysfunction in aged mice.

Improved physical function
Reduced frailty markers
Cleared senescent cells

Animal

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The Effects of Interval Resistance-Aerobic Training and Fisetin Supplementation on Asprosin and Selected Adipokines in Obese Men: A Double-Blind Randomized Control Trial

Alipour M et al. • Nutrients (2026)

Future research employing molecular readouts is warranted to confirm the underlying pathways involved.

Methods: Sixty sedentary men with obesity (BMI < 30 kg/m2) completed 12 weeks of thrice-weekly interval resistance training (eight exercises, 3 × 13 reps at 60% 1RM with 20% 1RM active rest), immediately followed by staged aerobic bouts (50-70% HRmax).
Furthermore, body mass index (BMI) showed a significant inter-group difference (p = 0.021), with post hoc analysis revealing that only the TF group reached a statistically significant reduction compared to the placebo (p = 0.024; 95% CI [-3.760, -0.172]).
The findings indicated that the TF group experienced the most substantial reductions in both asprosin (-60.71%) and MCP-1 (-46.50%) levels.

RCTn=60

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Targeting Cellular Senescence for Healthy Aging: Advances in Senolytics and Senomorphics

Alum EU et al. • Drug design, development and therapy (2025)

Targeting cellular senescence offers a promising avenue for promoting healthy aging and mitigating age-linked diseases.

Targeting cellular senescence offers a promising avenue for promoting healthy aging and mitigating age-linked diseases.
Continued research into senescence-modulating interventions may lead to novel therapeutics designed to prolong healthspan and lifespan.
Further research warranted to confirm findings

Systematic Review

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Effects and Mechanisms of Fisetin against Ischemia-reperfusion Injuries: A Systematic Review

Adeli OA et al. • Current pharmaceutical biotechnology (2024)

Fisetin, by antioxidant, anti-inflammatory, mitochondrial protection, promoting autophagy, and anti-apoptotic properties, can reduce cell injury due to myocardial, cerebral renal, and hepatic IRIs without any significant side effects.

Fisetin, by antioxidant, anti-inflammatory, mitochondrial protection, promoting autophagy, and anti-apoptotic properties, can reduce cell injury due to myocardial, cerebral renal, and hepatic IRIs without any significant side effects.
Further research warranted to confirm findings

Systematic Review

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Fisetin as a senotherapeutic agent: Evidence and perspectives for age-related diseases

Tavenier J et al. • Mechanisms of ageing and development (2024)

Our review of available data suggests that targeting senescent cells with fisetin offers a promising strategy for managing multiple chronic diseases, potentially transforming future healthcare for ...

Our review of available data suggests that targeting senescent cells with fisetin offers a promising strategy for managing multiple chronic diseases, potentially transforming future healthcare for older and multimorbid patients.

Systematic Review

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Senotherapy, cancer, and aging

Balducci L et al. • Journal of geriatric oncology (2024)

These elements may be responsible for tumor recurrence and treatment refractoriness.

Systematic review examining Fisetin efficacy
Further research warranted to confirm findings

Systematic Reviewn=3,000

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The Neuroprotective Role of Fisetin in Different Neurological Diseases: a Systematic Review

Jiang Y et al. • Molecular neurobiology (2023)

The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Fisetin, a flavonoid, has emerged as a novel potential molecule that enhances neural protection and reverses cognitive abnormalities.
The neuroprotective effects of fisetin are attributed to its multifaceted biological activity and multiple therapeutic mechanisms associated with different neurological disorders.
In this review article, we summarize recent research progression regarding the pharmacological effects of fisetin in treating several neurological diseases and the potential mechanisms.

Systematic Review

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Flavonoids nanostructures promising therapeutic efficiencies in colorectal cancer

Hassani S et al. • International journal of biological macromolecules (2023)

Nano delivery systems such as nanoliposomes, nanomicelles, silica nanoparticles have been investigated to overcome these difficulties.

Nano delivery systems such as nanoliposomes, nanomicelles, silica nanoparticles have been investigated to overcome these difficulties.
This review provides a summary of the efficiency of certain flavonoids and polyphenols (apigenin, genistein, resveratrol, quercetin, silymarin, catechins, luteolin, fisetin, gallic acid, rutin, and curcumin) on colorectal cancer models.

Systematic Review

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Biological effects and mechanisms of fisetin in cancer: a promising anti-cancer agent

Zhou C et al. • European journal of medical research (2023)

BioMed Central Ltd., part of Springer Nature.

The anticancer properties of fisetin can be attributed to a diverse array of molecules and signaling pathways, including vascular endothelial growth factor (VEGF), mitogen-activated protein kinase (MAPK), nuclear factor-kappa B (NF-κB), PI3K/Akt/mTOR, and Nrf2/HO-1.
Consequently, fisetin holds promise as a therapeutic agent for anticancer treatment.
In this review, we place emphasis on the biological functions and various molecular targets of fisetin in anticancer therapy.

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