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Fis8.0
Fisetin Research
Likely helpsModerate safety
55 peer-reviewed studies
What the evidence says
Likely helps
Fisetin appears to help in 3 of 3 studies with measurable effects — the evidence leans clearly favourable.
Most evidence is from high-quality randomised trials published 2014–2026 with a typical study size of 40 participants.
Based on 55 studies · 9 RCTs · 3,613 total participants
Confidence
High
What the studies found
3helped· 52 more without graded effect data
By outcome
Longevity & senolyticsClears senescent cells; human data still emerging · Ongoing
InflammationReduced inflammation through senescent cell clearance · 4-8 weeks
Mostly mechanism / observational6 studies
Glucose & metabolicSenolytic effects support metabolic health and aging · Ongoing
Mostly mechanism / observational5 studies
Cognitive function
Mostly mechanism / observational5 studies
Liver health
Too few graded studies1 study
By the numbers
Pulled from 31 studies with measurable effects
Likely real effects
100%
across studies
People studied
3,613
typical study: 40 people
Strongest designs
9
0 pooled, 9 randomised
Showed benefit
100%
3/3 studies
How long studies ran
Under a week
1
1–3 months
1
Populations Studied
Cancer patients2
CNS injury patients1
Various disease models1
Women with reproductive health conditions1
Active research area
44 studies in the last 5 years
201420202026
1Neuroprotection in brain and spinal cord injurySystematic ReviewCited 13×2025
Faysal M et al. · Naunyn-Schmiedeberg's archives of pharmacology (2025)
Flavonoids can enhance injury healing, reduce lesion size, and enhance synaptic plasticity and neurogenesis.
The full potential of flavonoids lies in their bioavailability, dose, and administration methods, but there are still challenges to overcome.
This review explores flavonoid-induced neuroprotection, its clinical implications, future research opportunities, and molecular mechanisms, highlighting the potential for innovative CNS injury therapies and improved patient health outcomes.
2Cellular senescence and age-related diseasesSystematic ReviewCited 14×2025
Moreover, recent advancements in SIRT6-regulated compounds (e.g., C3G, BZBS, Fisetin, FNDC5, Lycorine hydrochloride, and Ergothioneine) are discussed as potential therapeutic agents for these mediated diseases.
Lu Y et al. · Advanced biology (2025)
Furthermore, SIRT6 promotes autophagy, slowing cellular senescence via the modulation of various signaling pathways, including AMPK, IGF-Akt-mTOR, H133Y, IL-1β, and mitochondrial autophagy-related proteins.
Finally, SIRT6 regulates multiple signaling pathways, such asNF-κB, FOXO, and AMPK, to counteract the aging process.
Moreover, recent advancements in SIRT6-regulated compounds (e.g., C3G, BZBS, Fisetin, FNDC5, Lycorine hydrochloride, and Ergothioneine) are discussed as potential therapeutic agents for these mediated diseases.
So the synergistic effects of flavonoids with other drugs, pharmacokinetic studies, clinical trials and the safety of flavonoids are also incorporated in the discussion.
Cao Y et al. · Pharmacological research (2021)
So the synergistic effects of flavonoids with other drugs, pharmacokinetic studies, clinical trials and the safety of flavonoids are also incorporated in the discussion.
It is believed that more breakthrough studies are needed.
Overall, this review may shed some new light on the explicit recognition of the mechanisms of anti-hypertension actions of flavonoids, pointing out the limitations of relevant research at the current stage and the aspects that should be strengthened in future researches.
It also provides a brief overview of the molecular mechanisms of senescence and attempts to identify potential drivers and barriers for the clinical translation of those nutrients.
Braučič Mitrovic L et al. · International journal of molecular sciences (2026)
In recent years, cellular senescence, characterized by cell cycle arrest and development of a senescence-associated secretory phenotype (SASP), has emerged as a key mechanism of aging and ARDs and has been increasingly explored as a promising therapeutic target.
Among dietary bioactive ingredients, fisetin and quercetin have gained attention because of their potential to act as senolytics and senomorphics.
It also provides a brief overview of the molecular mechanisms of senescence and attempts to identify potential drivers and barriers for the clinical translation of those nutrients.
5Women's reproductive health outcomesSystematic Review2026
This review summarizes current experimental and clinical evidence, identifies critical gaps in mechanistic understanding, and discusses future directions for advancing fisetin as a promising non-hormonal therapeutic option in reproductive health and diseases.
El Sayed S et al. · Nutrients (2026)
Mechanistically, fisetin regulates several pathophysiological processes, including ovarian aging, fibrosis, angiogenesis, and hormonal regulation, suggesting its potential relevance to female reproductive health and disease.
Indeed, emerging evidence indicates that fisetin may support ovarian function and hormonal balance, modulate fibrosis and metabolism in benign gynecologic conditions, and suppress cell growth in gynecologic cancers.
Early-phase clinical studies in non-gynecologic conditions suggest an acceptable safety profile, although evidence in reproductive health remains absent.
6fisetin therapeutic potential in liver diseasesSystematic Review2025
Given its broad spectrum of beneficial effects and favorable safety profile, fisetin represents a compelling candidate for future studies in the prevention and management of IFALD.
Belka M et al. · Nutrients (2025)
More importantly, fisetin is recognized as a potent senolytic agent, selectively activating pro-apoptotic pathways in senescent cells, which are known sources of inflammation and tissue damage.
However, despite its promising pharmacological profile, the poor bioavailability of fisetin remains a significant limitation, particularly for parenteral use.
Emerging drug delivery systems such as liposomes and nanoparticles offer potential solutions.
This up-to-date summary of the anti-aging effect of certain phytochemicals has demonstrated powerful potential for anti-aging or anti-frailty in the human population.
Chen JC et al. · Critical reviews in food science and nutrition (2024)
In this article, we attempt to show the potential of Caenorhabditis elegans in the study of phytochemicals' effects on anti-aging by comparing it to other animal models.
Meanwhile, the frequency of phytochemicals and models studied or presented in publications since 2010 were analyzed, and the most commonly mentioned animal models were rats, mice, and the nematode C. elegans.
This up-to-date summary of the anti-aging effect of certain phytochemicals has demonstrated powerful potential for anti-aging or anti-frailty in the human population.
An open question remains as to which nanocarrier should be chosen to meet the abovementioned requirements and be able to enhance fisetin's therapeutic potential to treat a particular disease.
Szymczak J et al. · International journal of molecular sciences (2023)
Such molecules include fisetin, found in strawberries, and have shown great promise in treating Alzheimer's disease and cancer.
Unfortunately, because of their limited water solubility, low absorption, and poor bioavailability, the assistance of nanotechnology is required to allow them to fulfil their potential fully.
Here, we provide evidence that nanodelivery methods and structure modifications can improve fisetin bioavailability, which is linked to improvements in therapeutic efficacy.
The reported low toxicity and activity of fisetin on cancer cells indicate its valuable potential, but large-scale clinical trials are urgently needed to assess real chemotherapeutic efficacy of this flavonoid.
Markowska A et al. · Nutrients (2023)
In this review, we have summarized the results of studies on the anticancer effects of fisetin on selected female malignancies, both in in vitro and in vivo tests, i.e., breast, cervical, and ovarian cancer, published over the past two decades.
Until now, no article dedicated exclusively to the action of fisetin on female malignancies has appeared.
This review also describes a growing number of nanodelivery systems designed to improve the bioavailability and solubility of this natural compound.
However, further high-quality studies are needed to firmly establish the clinical efficacy of these phytochemicals against PCa.
Mia MAR et al. · Phytotherapy research : PTR (2023)
Some potential compounds, such as curcumin, phenethyl-isothiocyanate, fisetin, baicalein, berberine, lutein, and many others, exert an anti-PCa effect via inhibiting proliferation, metastasis, cell cycle progression, and normal apoptosis pathways.
In addition, multiple studies have demonstrated that the isolated natural compounds: d-limonene, paeonol, lanreotide, artesunate, and bicalutamide have potential synergistic effects.
Further, a significant number of natural compounds effectively target PCa stem cells.
Nutraceuticals and supplements show promising potential in the management of TBI.Trial registration: ClinicalTrials.gov identifier: NCT01814527.Trial registration: ClinicalTrials.gov identifier: NCT03032302.
Lucke-Wold B et al. · Nutritional neuroscience (2025)
Nutraceuticals and supplements show promising potential in the management of TBI.Trial registration: ClinicalTrials.gov identifier: NCT01814527.Trial registration: ClinicalTrials.gov identifier: NCT03032302.
12Systematic ReviewCited 11×n=100 · medium study2024
In summary, although certain polyphenols appear to exert some effect, their role in the prevention or treatment of CRC is inconclusive, and more clinical studies under more controlled conditions are needed.
López-Gómez L et al. · Nutrients (2024)
Curcumin demonstrated promise in various trials, mainly decreasing inflammatory cytokines, though results varied, and it did not lower intestinal adenomas or improve outcomes after chemotherapy.
Neither epigallocatechin gallate nor artepillin C reduced the incidence of adenomas.
Finally, fisetin seemed to improve the inflammatory status of patients under chemotherapy (5-fluorouracil).
In the future, these compounds may find applications in the prevention and treatment of gynecological cancers and breast cancer, but this requires further, more advanced research.
Wendlocha D et al. · Nutrients (2023)
The consumption of foods that are rich in phenolic compounds has chemopreventive effects on many cancers, including breast cancer, ovarian cancer, and endometrial cancer.
A wide spectrum of their health-promoting properties such as antioxidant, anti-inflammatory, and anticancer activities, has been demonstrated.
This paper analyzes the mechanisms of the anticancer action of selected common flavonols, including kemferol, myricetin, quercetin, fisetin, galangin, isorhamnetin, and morin, in preclinical studies, with particular emphasis on in vitro studies in gynecological cancers and breast cancer.
This review aims to summarize recent findings on the properties of phytochemicals in the modulation of sirtuin activity, with a particular focus on biochemical aspects.
Wiciński M et al. · Nutrients (2023)
Fisetin, through SIRT1 regulation, modifies lipid metabolism and anti-inflammatory processes.
Berberine has a wide spectrum of effects and a significant impact on SIRT1 signaling pathways.
Finally, kaempferol triggers anti-inflammatory and antioxidant effects through SIRT1 induction.
15Systematic ReviewCited 46×n=21 · very small study2021
In conclusion, the available evidence supports the potential use of these flavonols in prostate and bladder cancer, with a low expected toxicity, thus providing the rationale for clinical trials that explore dosing, settings for clinical use as well as their use in combination with other pharmacological and non-pharmacological interventions.
Crocetto F et al. · Nutrients (2021)
Furthermore, a higher dietary intake of flavonols was associated with a lower risk of both bladder and prostate cancer in epidemiological studies.
In this systematic review, we gathered all available evidence supporting the anti-cancer potential of selected flavonols (kaempferol, fisetin and myricetin) against bladder and prostate cancer.
Moreover, an attempt was made to collect the majority of substantive studies on bioactive potential of the selected flavonols, especially with regard to modulation of a range of signal transduction pathways that participate in cancer development.
Kubina R et al. · Nutrients (2021)
Special attention was paid to selected flavonols: fisetin, kaempferol, and quercetin in preclinical and in vitro studies.
Study results prove antiproliferative and proapoptotic properties of flavonols with regard to head and neck cancer.
However, few study papers evaluate specific activities during various processes associated with cancer progression.