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Gtk4.2
Gotu Kola Research
Mostly mechanism / observational
10 peer-reviewed studies
What the evidence says
Mostly mechanism / observational
Most Gotu Kola studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality randomised trials published 2000–2026 with a typical study size of 66 participants.
Based on 10 studies · 3 RCTs · 233 total participants
Confidence
Moderate confidence
By outcome
Cognitive functionEnhances working memory and cognitive function · 4-8 weeks
Kushwah S et al. · Current neuropharmacology (2023)
A rich knowledge base of traditional herbal plants (Turmeric, Gingko, Ashwagandha, Shankhpushpi, Giloy, Gotu kola, Garlic, Tulsi, Ginger, and Cinnamon) combined with modern science could suggest new functional leads for Alzheimer's drug discovery.
In this article Ayurveda, the ancient Indian herbal medicine system based on multiple clinical and experimental, evidence have been reviewed for treating AD and improving brain functioning.
This article presents a modern perspective on the herbs available in the ancient Indian medicine system as well as their possible mechanisms of action for AD treatment.
Overall, nearly one-quarter (23%) of adults currently take a supplement to maintain or improve brain health or delay and reverse dementia.
However, other botanicals that affect stress, focus, attention, and sleep have also been procured by dietary supplement companies developing products for improving both, short and long-term brain health.
Botanicals are discussed in terms of available clinical efficacy data and current safety profiles.
3Neuroprotective effects in Alzheimer's diseaseSystematic ReviewCited 115×2021
It is hoped that these medicinal plants can be used in drug discovery programs for identifying safe and efficacious small molecules for AD.
Gregory J et al. · Biomolecules (2021)
Methods-This article systematically reviews recent studies that have investigated the role of neuroprotective herbs and their bioactive compounds for dementia associated with Alzheimer's disease and pre-Alzheimer's disease.
PubMed Central, Scopus, and Google Scholar databases of articles were collected, and abstracts were reviewed for relevance to the subject matter.
Conclusions-Medicinal plants have great potential as part of an overall program in the prevention and treatment of cognitive decline associated with AD.
However, detailed scientific approaches on clinical trials regarding health benefits and nutritional values of C. asiatica are limited, hindering the perception of its benefits, mechanisms, and tox...
Chandrika UG et al. · Advances in food and nutrition research (2015)
However, detailed scientific approaches on clinical trials regarding health benefits and nutritional values of C. asiatica are limited, hindering the perception of its benefits, mechanisms, and toxicity in order to develop new drug prototypes.
In vitro studies have shown that the method of processing C. asiatica has an impact on its nutritional values and health-related beneficial compounds.
The composition of its compounds is influenced by different biotic and abiotic factors which need to be studied in detail to provide information to the public in order to maximize the usage of this valuable plant.
Pedregosa BIC, Navarro JC, Baroque GAB, Sta Maria MIN, De Leon MAJ, Trivilegio MJH, Batino LKJ, Nosce JA, Dorado MLM, Baroque AIC. · Complementary medicine research (2026)
However, the current evidence base remains limited, consisting primarily of animal experiments and small-scale human investigations exhibiting substantial methodological limitations and heterogeneity, precluding meaningful meta-analytic synthesis.
The absence of studies evaluating the full three-component Neurotain® Plus formulation or any combination of its constituents represents an important gap in the existing literature.
Randomized clinical trials and mechanistic investigations are warranted to clarify the therapeutic relevance, safety, and potential interactions of these compounds.
6Clinical signs improvement in hepatic encephalopathyRCTCited 2×n=66 · small study2006
In group combined treatment was significant improvement of clinical signs, psychometric tests, electroencephalography and serum biochemistry than in group with standard therapy, on term of 2 to 5 weeks.
Kaziulin AN et al. · Voprosy pitaniia (2006)
In group combined treatment was significant improvement of clinical signs, psychometric tests, electroencephalography and serum biochemistry than in group with standard therapy, on term of 2 to 5 weeks.
Formula includes extracts of plants: Bacopa monneria, Gingko biloba, Cat's Claw, Gotu Kola, Rosemary.
Further research warranted to confirm findings
7RCTCited 26×n=36 · small study2007
These finding do not support the use of a ginkgo biloba-containing supplement for improving cognitive function or quality of life in cognitively intact, older, healthy adults.
Carlson JJ et al. · Journal of the American Dietetic Association (2007)
Seventy-eight subjects (87%) completed both baseline and 4-month testing (n=36 in placebo group, n=42 in ginkgo biloba group).
One of six cognitive tests indicated significant protocol differences at 4 months (P=0.03), favoring the placebo.
These finding do not support the use of a ginkgo biloba-containing supplement for improving cognitive function or quality of life in cognitively intact, older, healthy adults.
The findings suggest the potential of aqueous extract of CA as adjuvant to antiepileptic drugs with an added advantage of preventing cognitive impairment.
Gupta YK et al. · Pharmacology, Biochemistry, and Behavior (2003)
Aqueous extract of Centella asiatica (300 mg/kg) decreased PTZ-kindled seizures and improved the kindling-induced learning deficit in rats.
Centella asiatica reduced oxidative stress markers (malondialdehyde) and increased glutathione in the brain.
Effects support a cognition-enhancing and antioxidant role for Centella asiatica.
These findings indicate that liposomal encapsulation enhances the bioactivity of C. asiatica extract during the inflammatory and proliferative phases of wound repair, supporting further development of LEC as a topical wound-healing formulation.
Chonsut P et al. · Frontiers in Medical Technology (2026)
Liposome-encapsulated Centella asiatica extract reduced TNF-α and IL-1β and enhanced dermal fibroblast viability and migration in vitro.
Topical application accelerated wound contraction in a rat excision model, reaching 99.9% closure by Day 12.