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Centella asiatica
Triterpenoid-rich herb that enhances collagen synthesis, supports neuroprotection, and reduces anxiety — unrelated to kola nut.
What the evidence says
Most Gotu Kola studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality randomised trials published 2000–2026 with a typical study size of 40 participants.
Based on 9 studies · 4 RCTs · 162 total participants
Confidence
ModerateBy outcome
Gotu Kola has an evidence score of 7/10 — strong evidence based on 9 indexed studies. Triterpenoid-rich herb that enhances collagen synthesis, supports neuroprotection, and reduces anxiety — unrelated to kola nut.
The commonly studied dose of Gotu Kola is 500-1000mg extract (or 1-2g dried herb). Research points to an estimated optimal dose around 1000mg extract, with a minimum effective dose near 500mg extract. Individual response varies — start low and adjust.
Timing is flexible for Gotu Kola — consistent daily use matters more than the time of day. Gotu kola (Centella asiatica) triterpenes — asiaticoside, madecassoside, asiatic acid, and madecassic acid — support collagen synthesis, wound healing, and cognitive function.
Bacopa Monnieri
Mostly mechanism / observationalEnhances memory formation and recall by supporting synaptic communication — benefits build over 8-12 weeks of consistent use.
Ginkgo Biloba
Probably helpsImproves cerebral blood flow and peripheral circulation — modest evidence for memory in older adults and cognitive decline.
Last reviewed May 2026 · evidence from 12 studies · how we score
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.
Gotu kola is a swamp plant used in Ayurvedic and Traditional Chinese Medicine for centuries. Known as 'the herb of longevity,' it's been used to enhance memory, reduce anxiety, and support skin healing. Contains triterpenoids that support collagen synthesis and may have neuroprotective effects. Often confused with (but unrelated to) kola nut.
Supports brain cell health and function
May enhance calming GABA signaling
Supports wound healing and skin health
How Gotu Kola works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
500-1000mg extract (or 1-2g dried herb)
Take with food
| Form | Type |
|---|---|
| 💊Standardized extract (triterpene content) | Recommended |
| 💊Dried herb | Alternative |
| 💧Tincture | Alternative |
| 🍵Tea | Alternative |
Extracts standardized to triterpene content (asiaticoside, madecassoside) are more consistent.
Minimum: 4 weeks
Optimal: 8 weeks
Cycling: Traditional Ayurvedic use suggests cycling. Try 6-8 weeks on, 2 weeks off.
Note: Can be taken any time. Some prefer morning for cognitive effects. Does not contain caffeine despite name similarity to kola nut.
Based on single small RCT (n=40) showing reduced acoustic startle response. Limited clinical evidence for anxiolytic effects.
Improved memory and mental clarity
Calming effects without drowsiness
May support wound healing and collagen
Avoid — may affect pregnancy
Avoid due to rare hepatotoxicity reports
May have additive calming effects
Rare liver toxicity reported; avoid combining
May affect blood sugar
Tip: Reduce dose
Tip: Take with food
Tip: Take in evening if problematic
Tip: Discontinue; cycle usage
Gotu Kola is generally safe at recommended doses, with a few precautions worth noting. The most commonly reported side effects are headache, GI upset, drowsiness. Use caution if any of these apply to you: Liver disease; Scheduled surgery (stop 2 weeks prior).
Rhodiola Rosea
Probably helpsFast-acting adaptogen that combats mental fatigue and improves cognitive performance under stress — works within days, not weeks.
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