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Gse7.5
Grape Seed Extract Research
Likely helpsHigh safety
33 peer-reviewed studies
What the evidence says
Likely helps
Grape Seed Extract appears to help in 5 of 6 studies with measurable effects — the evidence leans clearly favourable.
Most evidence is from high-quality meta-analyses and randomised trials published 2011–2026 with a typical study size of 105 participants.
Based on 33 studies · 10 meta-analyses · 14 RCTs · 12,078 total participants
Confidence
High
What the studies found
5helped1didn't help· 27 more without graded effect data
By outcome
Heart & blood pressureReduces blood pressure and improves endothelial function · 4-8 weeks
Mostly mechanism / observational14 studies
InflammationImproved circulation and modest blood pressure reduction · 4-8 weeks
Mostly mechanism / observational13 studies
Glucose & metabolic
Mostly mechanism / observational7 studies
Cholesterol & lipidsReduces blood pressure and improves endothelial function · 4-8 weeks
Mostly mechanism / observational6 studies
Weight management
Mostly mechanism / observational5 studies
Skin healthProtects against UV-induced skin damage · 4-8 weeks
28 studies in the last 5 years · Latest meta-analysis: 2025
201120182026
1Body weight reductionMeta-AnalysisCited 1×n=1,284 · large study2024
Our study suggests that grape products intake may help to decrease body weight in obese participants.
Goudarzi MA et al. · Current drug targets (2024)
Likely real
The outcomes have revealed grape products intake to significantly decrease body weight (p = 0.001) and body mass index (p = 0.004) in obese participants, and also, a greater effect was observed when grape seed extract was used.
Our study suggests that grape products intake may help to decrease body weight in obese participants.
Future large RCTs with longer duration and obese populations are needed to expand our findings.
2Adverse eventsMeta-AnalysisCited 47×n=7,690 · very large study2020
There is moderate-certainty evidence that phlebotonics probably reduce oedema slightly, compared to placebo; moderate-certainty evidence of little or no difference in QoL; and low-certainty evidence that these drugs do not influence ulcer healing.
Martinez-Zapata MJ et al. · The Cochrane database of systematic reviews (2020)
Noticeable harm
← WorseNo effectBetter →
Pooled data suggest that phlebotonics probably increase adverse events slightly, compared to placebo (RR 1.14, 95% CI 1.02 to 1.27; 37 studies; 5789 participants; moderate-certainty evidence).
There is moderate-certainty evidence that phlebotonics probably reduce oedema slightly, compared to placebo; moderate-certainty evidence of little or no difference in QoL; and low-certainty evidence that these drugs do not influence ulcer healing.
Moderate-certainty evidence suggests that phlebotonics are probably associated with a higher risk of adverse events than placebo.
Antioxidants, particularly melatonin and propolis, enhance periodontal and glycemic outcomes in T2D-periodontitis patients.
Abdulla SA et al. · Clinical and experimental dental research (2025)
Huge benefit
← WorseNo effectBetter →
Adjunctive antioxidants significantly improved CAL (melatonin: SMD -2.28, 95% CI -3.01 to -1.56; propolis: SMD -3.83, -4.79 to -2.87) and PD (melatonin: SMD -2.40, -3.14 to -1.66; propolis: SMD -1.78, -2.44 to -1.11).
Melatonin and propolis also reduced HbA1c (melatonin: SMD -2.28; propolis: SMD -3.83).
Antioxidants, particularly melatonin and propolis, enhance periodontal and glycemic outcomes in T2D-periodontitis patients.
5Dental enamel remineralizationMeta-AnalysisCited 8×n=23 · very small study2024
Within the limitations of this systematic review and metaanalysis, GSE and cranberries or their active compounds could represent an alternative for caries management.
García-Manríquez N et al. · Nutrition reviews (2024)
Huge benefit
← WorseNo effectBetter →
Likely real
Meta-analyses showed GSE was associated with enhanced remineralization of dental enamel (SMD = .96 95% CI [.45, 1.46], P < .0002) and of dentin (SMD = .65 95% CI [.13, 1.17], P = .01).
Within the limitations of this systematic review and metaanalysis, GSE and cranberries or their active compounds could represent an alternative for caries management.
Further clinical trials are needed to verify this effect in a clinical setting.
8Obesity prevention and treatmentSystematic ReviewCited 42×2020
This systematic-review examined the effects of Grape Seed Extract.
Liu M et al. · Obesity facts (2020)
As a major component of metabolic syndrome, obesity is closely related to many diseases such as type 2 diabetes mellitus, hyperlipidemia, hypertension, coronary heart disease, stroke and cancer.
Hence, the problem of obesity cannot be ignored, and recent studies have shown that grape seed proanthocyanidin extract (GSPE) has an antiobesity effect.
This paper systematically reviews the research progress and potential mechanism of GSPE emphasizing on obesity prevention and treatment.
Caries prevention by grape seed extract may be unique compared with fluoride, and is linked to grape seed extract's bacteriostatic and collagen crosslinking properties.
Delimont NM et al. · Nutrition and health (2020)
Caries prevention by grape seed extract may be unique compared with fluoride, and is linked to grape seed extract's bacteriostatic and collagen crosslinking properties.
Future research should investigate potential delivery methods, and benefits of combined grape seed extract use with known caries preventative agents, in human participants.
10Meta-AnalysisCited 17×n=19 · very small study2021
It appears that GSE supplementation can remarkably modulate the body's redox system, particularly through the inhibition of lipid peroxidation, but has neutral or mildly beneficial effects on inflammatory responses.
Foshati S et al. · International journal of clinical practice (2021)
It appears that GSE supplementation can remarkably modulate the body's redox system, particularly through the inhibition of lipid peroxidation, but has neutral or mildly beneficial effects on inflammatory responses.
Therefore, this review discusses the protective and therapeutic mechanisms of grape seed against neurological disorders and, in the end, links GSE to microRNAs as future therapeutic developments.
Mahdipour R et al. · Nutritional neuroscience (2023)
Grape seed contains several flavonoids and non-flavonoids and exerts potent antioxidant and anti-inflammatory effects.
In addition, polyphenols and flavanols can maintain cellular proteostasis.
Since impaired proteostasis is closely involved in all amyloid diseases, particularly neurodegenerative diseases, grape seeds extract can be a valuable therapeutic agent.
Improvement of endothelial dysfunction and reduction of oxidative stress associated with HTN are the main mechanisms involved in the blood pressure-lowering effects of these by-products.
López-Fernández-Sobrino R et al. · Critical reviews in food science and nutrition (2023)
In addition, molecular mechanisms involved in their bioactivity were also evaluated.
Among the winery by-products, grape seed extracts have widely shown antihypertensive properties in both animal and human studies.
Moreover, recent evidence suggests that grape stem, skin and pomace and wine lees may also have great potential to manage HTN, although more studies are needed in order to confirm their potential in humans.
In conclusion, bilberry and blackcurrant extract appears effective in lowering HbA1c and total and LDL cholesterol, whereas grape seed extract may lower total and LDL cholesterol, and blood pressure, in specific population groups.
Grohmann T et al. · Nutrients (2021)
Intervention with grape seed extract may reduce systolic and diastolic blood pressure in subjects with hypertension or metabolic syndrome.
Differential responsiveness in cholesterol and blood pressure outcomes between stratified populations could not be explained by age, dose or study duration.
In conclusion, bilberry and blackcurrant extract appears effective in lowering HbA1c and total and LDL cholesterol, whereas grape seed extract may lower total and LDL cholesterol, and blood pressure, in specific population groups.
14LDL cholesterol reductionRCTCited 6×n=105 · medium study2023
Our results confirm the LDL-C-lowering properties of monacolin are clinically meaningful even in lower doses of 3 mg/day.
Angelopoulos N et al. · Nutrients (2023)
Large benefit
← WorseNo effectBetter →
Likely real
LDL-C decreased by 26.46% on average (p < 0.001) during treatment with 10 mg of monacolin and by 16.77% on average during treatment with 3 mg of monacolin (p < 0.001).
We observed a slight but significant reduction of the triglyceride levels only in the high-dose-treated group (mean -4.25%; 95% CI of mean -11.11 to 2.61).
No severe adverse events occurred during the study.
More studies are needed to confirm the results of this study.
Ghanbari P et al. · International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition (2024)
Conclusions: GSE can be effective in improving oxidative stress and QoL in patients with NAFLD.
More studies are needed to confirm the results of this study.
VVSE significantly reduced venous reflux time across both superficial and deep veins, improving patient-reported symptoms compared with lifestyle modifications alone.
Bae S et al. · Journal of vascular surgery. Venous and lymphatic disorders (2026)
VVSE significantly reduced venous reflux time across both superficial and deep veins, improving patient-reported symptoms compared with lifestyle modifications alone.
The beneficial effects were consistent across diverse patient subgroups and particularly noteworthy in deep venous insufficiency.
This article discusses the therapeutic properties of natural products, nutraceuticals, and Chinese compounds for the prevention and treatment of liver cancer.
Islam MR et al. · Medical oncology (Northwood, London, England) (2024)
This study reviews natural compounds, such as curcumin, resveratrol, green tea catechins, grape seed extracts, vitamin D, and selenium.
Preclinical and clinical studies have shown that these medications reduce the risk of liver cancer through their antiviral, anti-inflammatory, antioxidant, anti-angiogenic, and antimetastatic properties.
This article discusses the therapeutic properties of natural products, nutraceuticals, and Chinese compounds for the prevention and treatment of liver cancer.
Vitis vinifera seed extract was noninferior to MPFF in relieving venous symptoms and improving the quality of life in patients with chronic venous disease.
Kim SM et al. · Annals of vascular surgery (2024)
The CIVIQ-20 scores at 8 weeks were significantly reduced compared to those at baseline in both groups.
No significant intergroup difference in the change of CIVIQ-20 at 8 weeks from baseline was observed (-8.31 ± 14.63 vs. -10.35 ± 14.38, P = 0.29, 95% confidence interval -1.65 to 5.72).
The lower limit of the 95% confidence interval was within the predefined noninferiority margin of 6.9.
The overall results showed that the extracts of cranberry and grape seed were effective in reducing the virulence factors of the oral pathogen.
Castellanos JS et al. · BMC oral health (2024)
The overall results showed that the extracts of cranberry and grape seed were effective in reducing the virulence factors of the oral pathogen.
According to the data, proanthocyanidins are the active components in cranberry and grape seed that effectively resist S. mutans.
They can inhibit the formation of insoluble polysaccharides in the extracellular matrix and prevent glycan-mediated adhesion, cohesion, and aggregation of the proteins in S. mutans.
Grape seed proanthocyanidin extracts showed the ability to reduce cytotoxicity and genotoxicity through the comet assay and the micronucleus technique.
Mancini M et al. · Current nutrition reports (2023)