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Gse6.0
Grape Seed Extract Research
Likely helps
70 peer-reviewed studies
What the evidence says
Likely helps
Grape Seed Extract appears to help in 8 of 10 studies with measurable effects — the evidence leans clearly favourable.
Most evidence is from high-quality meta-analyses and randomised trials published 2009–2026 with a typical study size of 105 participants.
Based on 70 studies · 15 meta-analyses · 40 RCTs · 12,078 total participants
Confidence
High confidence
What the studies found
8helped1unclear1didn't help· 60 more without graded effect data
By outcome
InflammationImproved circulation and modest blood pressure reduction · 4-8 weeks
Probably helps22 studies
Heart & blood pressureReduces blood pressure and improves endothelial function · 4-8 weeks
Likely helps20 studies
Weight management
Mostly mechanism / observational12 studies
Glucose & metabolic
Mostly mechanism / observational10 studies
Oral & dental health
Mostly mechanism / observational8 studies
Cholesterol & lipidsReduces blood pressure and improves endothelial function · 4-8 weeks
Mostly mechanism / observational7 studies
Skin healthProtects against UV-induced skin damage · 4-8 weeks
39 studies in the last 5 years · Latest meta-analysis: 2025
200920172026
1Body weight reductionMeta-AnalysisCited 1×n=1,284 · large study2024
Our study suggests that grape products intake may help to decrease body weight in obese participants.
Goudarzi MA et al. · Current drug targets (2024)
Likely real
The outcomes have revealed grape products intake to significantly decrease body weight (p = 0.001) and body mass index (p = 0.004) in obese participants, and also, a greater effect was observed when grape seed extract was used.
Our study suggests that grape products intake may help to decrease body weight in obese participants.
Future large RCTs with longer duration and obese populations are needed to expand our findings.
2Adverse eventsMeta-AnalysisCited 47×n=7,690 · very large study2020
There is moderate-certainty evidence that phlebotonics probably reduce oedema slightly, compared to placebo; moderate-certainty evidence of little or no difference in QoL; and low-certainty evidence that these drugs do not influence ulcer healing.
Martinez-Zapata MJ et al. · The Cochrane database of systematic reviews (2020)
Noticeable harm
← WorseNo effectBetter →
Pooled data suggest that phlebotonics probably increase adverse events slightly, compared to placebo (RR 1.14, 95% CI 1.02 to 1.27; 37 studies; 5789 participants; moderate-certainty evidence).
There is moderate-certainty evidence that phlebotonics probably reduce oedema slightly, compared to placebo; moderate-certainty evidence of little or no difference in QoL; and low-certainty evidence that these drugs do not influence ulcer healing.
Moderate-certainty evidence suggests that phlebotonics are probably associated with a higher risk of adverse events than placebo.
Antioxidants, particularly melatonin and propolis, enhance periodontal and glycemic outcomes in T2D-periodontitis patients.
Abdulla SA et al. · Clinical and experimental dental research (2025)
Huge benefit
← WorseNo effectBetter →
Adjunctive antioxidants significantly improved CAL (melatonin: SMD -2.28, 95% CI -3.01 to -1.56; propolis: SMD -3.83, -4.79 to -2.87) and PD (melatonin: SMD -2.40, -3.14 to -1.66; propolis: SMD -1.78, -2.44 to -1.11).
Melatonin and propolis also reduced HbA1c (melatonin: SMD -2.28; propolis: SMD -3.83).
Antioxidants, particularly melatonin and propolis, enhance periodontal and glycemic outcomes in T2D-periodontitis patients.
10Dental enamel remineralizationMeta-AnalysisCited 8×n=23 · very small study2024
Within the limitations of this systematic review and metaanalysis, GSE and cranberries or their active compounds could represent an alternative for caries management.
García-Manríquez N et al. · Nutrition reviews (2024)
Huge benefit
← WorseNo effectBetter →
Likely real
Meta-analyses showed GSE was associated with enhanced remineralization of dental enamel (SMD = .96 95% CI [.45, 1.46], P < .0002) and of dentin (SMD = .65 95% CI [.13, 1.17], P = .01).
Within the limitations of this systematic review and metaanalysis, GSE and cranberries or their active compounds could represent an alternative for caries management.
Further clinical trials are needed to verify this effect in a clinical setting.
11Systolic blood pressure reductionMeta-AnalysisCited 94×n=390 · medium study2011
Based on the currently available literature, grape seed extract appears to significantly lower systolic blood pressure and heart rate, with no effect on lipid or CRP levels.
Feringa HH et al. · Journal of the American Dietetic Association (2011)
Grape seed extract significantly lowered systolic blood pressure (weighted mean difference -1.54 mm Hg, 95% CI -2.85 to -0.22, P=0.02).
Grape seed extract significantly lowered heart rate (weighted mean difference -1.42 bpm, 95% CI -2.50 to -0.34, P=0.01).
No significant effect on diastolic blood pressure, lipid levels, or CRP was found.
13Obesity prevention and treatmentSystematic ReviewCited 42×2020
This systematic-review examined the effects of Grape Seed Extract.
Liu M et al. · Obesity facts (2020)
As a major component of metabolic syndrome, obesity is closely related to many diseases such as type 2 diabetes mellitus, hyperlipidemia, hypertension, coronary heart disease, stroke and cancer.
Hence, the problem of obesity cannot be ignored, and recent studies have shown that grape seed proanthocyanidin extract (GSPE) has an antiobesity effect.
This paper systematically reviews the research progress and potential mechanism of GSPE emphasizing on obesity prevention and treatment.
Caries prevention by grape seed extract may be unique compared with fluoride, and is linked to grape seed extract's bacteriostatic and collagen crosslinking properties.
Delimont NM et al. · Nutrition and health (2020)
Caries prevention by grape seed extract may be unique compared with fluoride, and is linked to grape seed extract's bacteriostatic and collagen crosslinking properties.
Future research should investigate potential delivery methods, and benefits of combined grape seed extract use with known caries preventative agents, in human participants.
15Meta-AnalysisCited 17×n=19 · very small study2021
It appears that GSE supplementation can remarkably modulate the body's redox system, particularly through the inhibition of lipid peroxidation, but has neutral or mildly beneficial effects on inflammatory responses.
Foshati S et al. · International journal of clinical practice (2021)
It appears that GSE supplementation can remarkably modulate the body's redox system, particularly through the inhibition of lipid peroxidation, but has neutral or mildly beneficial effects on inflammatory responses.
This review identifies the need for targeted research on the distinct characteristics of grape seed varieties and their implications for health and agriculture in Iran.
Nourbakhsh SA, Rahimi E, Khamesipour F. · Veterinary medicine and science (2026)
Seed extract antioxidant activity ranged from 34.03% (Green) to 53.63% (Black).
Specifically, the Black grape seed extract demonstrated the highest total antioxidant capacity with DPPH (53.63%-0.34%), IC50 and AEAC (7.41 and 16.92 mg/mL) and a total phenolic content of 3 0.01 mg tannic acid/g DM.
Iranian grape seeds show promising potential as a source of antioxidants and natural antimicrobial agents.
In contrast, quercetin and curcumin supplementation did not show a statistically significant difference compared to control groups in these outcomes.
Kyaw MT, Oo PS, Sumera A, Sivakumar A, Santiago C, Aung YN. · International journal of hematology-oncology and stem cell research (2025)
In contrast, quercetin and curcumin supplementation did not show a statistically significant difference compared to control groups in these outcomes.
All included studies reported significant effects of various supplements on key biomarkers, including total iron (Fe), ferritin, total iron-binding capacity (TIBC), total antioxidant capacity (TAC), malondialdehyde (MDA), and liver enzymes (AST, ALT).
Silymarin, green tea, and grape seed extract (GSE) supplementation demonstrated notable reductions in total Fe, Ferritin, ASL, and ALT levels.
Therefore, this review discusses the protective and therapeutic mechanisms of grape seed against neurological disorders and, in the end, links GSE to microRNAs as future therapeutic developments.
Mahdipour R et al. · Nutritional neuroscience (2023)
Grape seed contains several flavonoids and non-flavonoids and exerts potent antioxidant and anti-inflammatory effects.
In addition, polyphenols and flavanols can maintain cellular proteostasis.
Since impaired proteostasis is closely involved in all amyloid diseases, particularly neurodegenerative diseases, grape seeds extract can be a valuable therapeutic agent.
Improvement of endothelial dysfunction and reduction of oxidative stress associated with HTN are the main mechanisms involved in the blood pressure-lowering effects of these by-products.
López-Fernández-Sobrino R et al. · Critical reviews in food science and nutrition (2023)
In addition, molecular mechanisms involved in their bioactivity were also evaluated.
Among the winery by-products, grape seed extracts have widely shown antihypertensive properties in both animal and human studies.
Moreover, recent evidence suggests that grape stem, skin and pomace and wine lees may also have great potential to manage HTN, although more studies are needed in order to confirm their potential in humans.
20HbA1c, cholesterol levels, and blood pressureSystematic Reviewn=20 · very small study2021
In conclusion, bilberry and blackcurrant extract appears effective in lowering HbA1c and total and LDL cholesterol, whereas grape seed extract may lower total and LDL cholesterol, and blood pressure, in specific population groups.
Grohmann T et al. · Nutrients (2021)
Intervention with grape seed extract may reduce systolic and diastolic blood pressure in subjects with hypertension or metabolic syndrome.
Differential responsiveness in cholesterol and blood pressure outcomes between stratified populations could not be explained by age, dose or study duration.
In conclusion, bilberry and blackcurrant extract appears effective in lowering HbA1c and total and LDL cholesterol, whereas grape seed extract may lower total and LDL cholesterol, and blood pressure, in specific population groups.