Zamani M, Ashtary-Larky D, Nosratabadi S, Bagheri R, Wong A, Rafiei MM · Phytother Res (2023)
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16 peer-reviewed studies
What the evidence says
Most Gymnema Sylvestre studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 2007–2026 with a typical study size of 81 participants.
Based on 16 studies · 2 meta-analyses · 8 RCTs · 111 total participants
Confidence
High confidenceBy outcome
9 studies in the last 5 years · Latest meta-analysis: 2023
Zamani M, Ashtary-Larky D, Nosratabadi S, Bagheri R, Wong A, Rafiei MM · Phytother Res (2023)
Devangan S, Varghese B, Johny E, Gurram S, Adela R · Phytother Res (2021)
Pothuraju R, Sharma RK, Chagalamarri J, Jangra S, Kumar Kavadi P · J Sci Food Agric (2014)
In plain English: This systematic-review examined the effects of Gymnema Sylvestre.
· International journal of molecular sciences (2026)
Leach MJ · J Altern Complement Med (2007)
Kashima N, Kimura K, Nishitani N, Yamaoka Endo M, Fukuba Y, Kashima H · Nutrients (2020)
Turner S, Diako C, Kruger R, Wong M, Wood W, Rutherfurd-Markwick K · Nutrients (2022)
Nelson I, Kruger R, Hsiao D, Stice E, Ali A · Nutrients (2025)
Zuñiga LY, González-Ortiz M, Martínez-Abundis E · J Med Food (2017)
Gaytán Martínez LA, Sánchez-Ruiz LA, Zuñiga LY, González-Ortiz M, Martínez-Abundis E · J Med Food (2021)
In plain English: These beneficial effects occur in the absence of biochemical evidence of kidney and liver toxicity.
Buccato DG, Ullah H, De Lellis LF, Morone MV, Larsen DS, Di Minno A, Cordara M, Piccinocchi R, Baldi A, Greco A, Santonastaso S, Sacchi R, Daglia M. · Nutrients (2024)
In plain English: An evidence-based review (Natural Standard) summarized gymnema's traditional use and clinical evidence for blood sugar.
Ulbricht C et al. · Journal of dietary supplements (2011)
In plain English: In a head-to-head RCT, gymnema and berberine both improved adipokines and body composition.
Bandala C et al. · Nutrients (2024)
In plain English: A systematic review of appetite-suppressing plant extracts included gymnema among candidates for weight control.
Astell KJ et al. · Complementary therapies in medicine (2013)
In plain English: Using GS with an ad libitum regimen reduced sugar cravings and changed sweet food desire and consumption in people identifying as having a sweet tooth.
Wh H, R K, C D, I N, E S, A A. · Appetite (2025)
In plain English: An open-label study reported improved glycemic markers with gymnema in type 2 diabetes.
Kumar SN et al. · Journal of dietary supplements (2010)