34 peer-reviewed studies · Evidence score: 8/10
Górska-Jakubowska S et al. • Nutrients (2025)
In this review, we aim to analyze the anti-cancer effects of edible/medicinal mushrooms, including Schizophyllum commune, Trametes versicolor, Grifola frondosa, Ganoderma lucidum, Lentinula edodes, Laetiporus sulphureus, Boletus edulis, and Phellinus igniarius, as well as their potential anti-cancer mechanisms, providing strong theoretical support for the further development of edible/medicinal mushroom anti-cancer products.
Sevindik M et al. • International journal of medicinal mushrooms (2025)
However, most of the available data are at the preclinical level, and more comprehensive toxicological and pharmacokinetic studies are needed to ensure clinical applicability.
Szelenberger R et al. • Molecules (Basel, Switzerland) (2025)
Presented evidence indicates that fungal polysaccharides possess considerable potential as multifunctional hepatoprotective agents, highlighting the need for further mechanistic insight and clinical validation.
Shevchuk Y et al. • Ageing research reviews (2023)
Maitake or hen-of-the-woods), the genus Pleurotus (e.g. oyster mushrooms), and Agaricus subrufescens (i.e. the almond mushroom).
Gariboldi MB et al. • International journal of molecular sciences (2023)
We also report insights into the relationship between dietary consumption of edible mushrooms and breast cancer risk, and the results of clinical studies and meta-analyses focusing on the effects of fungal extracts on breast cancer patients.
Cui FJ et al. • International journal of biological macromolecules (2024)
The regulation strategies including strain improvement, process optimization and genetic engineering were also summarized for maximum production of G. frondosa polysaccharides.
Rai SN et al. • Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (2021)
In silico approaches provide an alternative method with low cost that has been successfully implemented to cure ND disorders in recent days.
Xu J et al. • Nutrients (2022)
In summary, there is a need to continue to explore the use of those extracts and to further validate their safety and efficacy.
Roghani-Shahraki H et al. • Journal of cellular physiology (2021)
Using herbal products, such as teas and mushrooms, or their derivatives, Rosmarinus officinalis Linn, Curcuma longa, Green tea, Lippia triphylla, Lippia citriodora, Plantago asiatica L, Vine tea, and Grifola frondosa have been proved to exert several therapeutic impacts on lipid profile and its related disorders, and we would provide a brief review on them in this literature.
Zhao F et al. • Journal of ethnopharmacology (2021)
GFP is a potential candidate for tumor treatment and clinical trials.
Hetland G et al. • Scandinavian journal of immunology (2021)
Scandinavian Journal of Immunology
Dai R et al. • Molecules (Basel, Switzerland) (2021)
In this review, we not only list the structures and functions of pharmaceutically active components isolated from mycomedicine, but also summarise the mechanisms underlying the potent bioactivities of several representative mushrooms in the Kingdom Fungi against various types of tumour.
Narayanan S et al. • Current oncology reports (2023)
More trials are needed to explore mushroom use during and after cancer treatment.
Hetland G et al. • Nutrients (2020)
This article reviews preclinical and clinical findings with these mushrooms and the mechanisms behind them.
Wong JH et al. • Applied microbiology and biotechnology (2020)
Antineoplastic effectiveness in human clinical trials and mechanism of anticancer action have been reported for Antrodia camphorata, Cordyceps sinensis, Coriolus versicolor, Ganoderma lucidum, Grifola frondosa, and Lentinula edodes.
He Y et al. • Progress in molecular biology and translational science (2019)
In this article, based on the search results of Chinese VIP, CNKI, Wanfang database and PubMed database, 108 independent studies were summarized.
Huang S et al. • Carbohydrate polymers (2020)
At present, there are few kinds of selenium polysaccharide, but its structure is very complex.
He Y et al. • Discovery medicine (2018)
The chemical structure, the antitumor, immunomodulatory, anti-diabetic, anti-hyperlipidemia, and antiviral activities and molecular mechanisms of GFP are reviewed and discussed.
He X et al. • International journal of biological macromolecules (2017)
Modern people mainly use it to assist in the treatment of diabetes mellitus and various cancers.
Phan CW et al. • Critical reviews in biotechnology (2015)
However, this review focuses on in vitro evidence and clinical trials with humans are needed.