1In VitroCited 58×2010
In plain English: Taken together, these data demonstrate that MG attenuates LPS-mediated inflammation in MPhi and insulin resistance in adipocytes, possibly by preventing the activation of MAPK, NF-kappaB, and AP-1, which are central to inflammatory cytokine production in WAT.
Bumrungpert A, Kalpravidh RW, Chuang CC, Overman A, Martinez K, Kennedy A, McIntosh M · J Nutr (2010)
- In-vitro study in cultured human macrophages (U937) and primary human adipocytes
- Xanthones reduced TNF-α, IL-6 and IP-10 expression dose-dependently
- Attenuated MAPK and AP-1 activation; gamma-mangostin also reduced NF-κB