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Mgs2.5

Mangosteen Research

Mostly mechanism / observationalModerate safety

4 peer-reviewed studies

What the evidence says

Mostly mechanism / observational

Most Mangosteen studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.

Most evidence is from medium-quality randomised trials published 2008–2017 with a typical study size of 50 participants.

Based on 4 studies · 2 RCTs · 90 total participants

Confidence

Low

By outcome

InflammationA small pilot found reduced C-reactive protein only at the highest juice dose; strong anti-inflammatory action is preclinical · 8 weeks (high dose, pilot data)
Too few graded studies2 studies

Older research base

Newest study from 2017

20082017

1In Vitro2010

Alpha- and gamma-mangostin attenuated LPS-induced inflammatory gene expression and signaling (MAPK, AP-1, NF-κB) in cultured human cells.

Bumrungpert A, Kalpravidh RW, Chuang CC, Overman A, Martinez K, Kennedy A, McIntosh M · J Nutr (2010)

In-vitro study in cultured human macrophages (U937) and primary human adipocytes
Xanthones reduced TNF-α, IL-6 and IP-10 expression dose-dependently
Attenuated MAPK and AP-1 activation; gamma-mangostin also reduced NF-κB

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2Pilotn=40 · small study2009

A proprietary mangosteen juice blend reduced CRP versus placebo only at the highest 18 oz/day dose, with no significant change in other inflammatory markers.

Udani JK, Singh BB, Barrett ML, Singh VJ · Nutr J (2009)

8-week randomized, double-blind, placebo-controlled pilot in 40 obese adults with elevated CRP
Significant CRP reduction vs placebo ONLY in the highest-dose (18 oz/day) group
Other inflammatory cytokines and F2-isoprostane showed no significant difference

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3RCTn=50 · small study2017

Locally applied 4% mangosteen pericarp gel significantly improved periodontal parameters and reduced Treponema denticola versus placebo over 3 months.

Mahendra J, Mahendra L, Svedha P, Cherukuri S, Romanos GE · J Investig Clin Dent (2017)

Randomized controlled trial, 50 chronic-periodontitis patients (25 gel, 25 placebo)
Probing depth, attachment level, bleeding and plaque indices improved vs placebo at 3 months
Reduced subgingival Treponema denticola

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4RCT2008

Pericarp gel applied as an adjunct to scaling and root planing produced greater reductions in pocket depth, gingival index, and bleeding than treatment alone.

Rassameemasmaung S, Sirikulsathean A, Amornchat C, Maungmingsook P, Rojanapanthu P, Gritsanaphan W · Complement Ther Med (2008)

Randomized trial of pericarp gel adjunct to scaling/root planing for periodontitis
Greater reduction in probing depth, gingival index and bleeding on probing vs control at 3 months
Local topical use; outcome limited to periodontal markers

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View in Research Library

Mangosteen Research

Mostly mechanism / observational

Xanthones from mangosteen inhibit inflammation in human macrophages and in human adipocytes exposed to macrophage-conditioned media.

Evaluation of Mangosteen juice blend on biomarkers of inflammation in obese subjects: a pilot, dose finding study.

Clinical and microbiological efficacy of 4% Garcinia mangostana L. pericarp gel as local drug delivery in the treatment of chronic periodontitis: A randomized, controlled clinical trial.

Topical application of Garcinia mangostana L. pericarp gel as an adjunct to periodontal treatment.