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Nac6.0
NAC Research
Likely helps
806 peer-reviewed studies
What the evidence says
Likely helps
NAC appears to help in 5 of 7 studies with measurable effects — the evidence leans clearly favourable.
Most evidence is from high-quality meta-analyses and randomised trials published 1982–2026 with a typical study size of 220 participants.
Based on 802 studies · 134 meta-analyses · 609 RCTs · 20,134 total participants
Confidence
High confidence
What the studies found
5helped2unclear· 795 more without graded effect data
2Progesterone levels in women with PCOSMeta-Analysisn=2,515 · very large study2025
In plain English: NAC had a major effect on progesterone, endometrial thickness, and LH levels in women with PCOS.
Viña I et al. · Nutrients (2025)
Huge benefit
← WorseNo effectBetter →
Likely real
NAC was associated with a statistically significant increase in progesterone (SMD 0.95, 95% CI: 0.13-1.77, p = 0.02) and endometrial thickness (SMD 0.58, 95% CI: 0.10-1.06, p = 0.02) compared to the placebo and other drugs (SMD 0.71, 95% CI: 0.48-0.94, p < 0.0001).
LH levels were significantly increased by NAC compared to metformin (SMD 0.67, 95% CI: 0.23-1.12, p = 0.003).
NAC had a major effect on progesterone, endometrial thickness, and LH levels in women with PCOS.
3Incidence of anti-TB drug induced liver injuryMeta-Analysisn=3,423 · very large study2023
Akkahadsee P et al. · Scientific reports (2023)
Huge benefit
← WorseNo effectBetter →
The NMA indicated that supplementation of Turmeric plus Tinospora cordifolia (RR 0.07; 95% CI 0.02 to 0.28), and N-acetyl cysteine (NAC) (RR 0.09; 95% CI 0.01 to 0.75) significantly reduced the incidence of anti-TB DILI compared with placebo.
In addition, poly herbal product significantly reduced alkaline phosphatase (ALP) (MD - 21.80; 95% CI - 33.80 to - 9.80) and total bilirubin (Tbil) compared with placebo (MD - 0.51; 95% CI - 0.76 to - 0.26).
There was no statistically significant difference in the occurrence of AEs in any intervention.
4Depressive symptoms in patients with psychiatric problemsMeta-Analysisn=904 · large study2024
In plain English: Our findings indicate that adjunctive NAC can ameliorate depressive symptoms in patients with psychiatric problems, particularly bipolar disorder.
Peng TR et al. · General hospital psychiatry (2024)
Our findings indicate that adjunctive NAC can ameliorate depressive symptoms in patients with psychiatric problems, particularly bipolar disorder.
However, large-scale clinical trials were needed to substantiate our results due to the wide CI value.
5Substance use cravingsMeta-Analysisn=623 · large study2024
In plain English: Addiction Biology published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction.
Winterlind EL et al. · Addiction biology (2024)
No clear effect
← WorseNo effectBetter →
The most targeted substance in the clinical trials was alcohol (3/9; 33.3%), followed by tobacco (2/9; 22.2%) and multiple substances (2/9; 22.2%).
NAC did not significantly outperform placebo in reducing symptoms of craving in the meta-analysis (SMD = 0.189, 95% CI = -0.015-0.393).
Heterogeneity was very high in the meta-analysis (99.26%), indicating that findings may have been influenced by clinical or methodological differences in the study protocols.