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Noopept (N-Phenylacetyl-L-prolylglycine ethyl ester)
Synthetic peptide ~1,000x more potent than piracetam; studied for memory and learning, with limited controlled human data.
Research compound — not a dietary supplement
Noopept is a research compound, not a regulated dietary supplement. It is sold for research or off-label use. The evidence below is largely preclinical (animal and in-vitro) or early-stage, so no evidence score is assigned. This page is provided for transparency and education — it is not a recommendation to use. Consult a qualified healthcare provider, and be aware that purity, dosing, and legal status vary by jurisdiction.
What the evidence says
Most Noopept studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from medium-quality studies published 2007–2026 with a typical study size of 60 participants.
Based on 13 studies · 120 total participants
Confidence
Low confidenceBy outcome
Earns an Emerging 4: a small open-label Russian stroke study and mechanistic NGF/BDNF data are encouraging, but evidence is dominated by small unrandomised clinical studies and preclinical work, with no randomised placebo-controlled trial, no Western trials and no FDA approval.
Noopept is a synthetic nootropic peptide developed in Russia that is estimated to be 1000 times more potent than piracetam by weight. Despite being called a racetam by some, it has a different structure (dipeptide). It raised NGF and BDNF in rats.
Human data are Russian open-label studies in people with mild cognitive impairment after stroke or injury, which reported mild improvement.
Increases growth factors
Enhances glutamate signaling
Protects neurons from damage
How Noopept works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
Popular for studying and cognitive enhancement
Tip: Reduce dose
Tip: Do not automatically add choline to treat a suspected adverse effect. New or persistent symptoms need assessment, with urgency determined by the symptoms.
Tip: Avoid late doses
Noopept has an evidence score of 4/10 — emerging evidence based on 13 indexed studies. Synthetic peptide ~1,000x more potent than piracetam; studied for memory and learning, with limited controlled human data. Representative study: PMID 30295186.
The commonly studied dose of Noopept is 10-20 mg daily in divided doses (the cited trials used 20 mg a day, in patients after stroke or with tuberculosis). Label products go up to 30 mg, above that dose. Individual needs vary — start at the lower end of the range and adjust based on how you respond.
The best time to take Noopept is in the morning. Taking it with food is preferred. Noopept (N-phenylacetyl-L-prolylglycine ethyl ester) is a synthetic nootropic peptide with rapid onset.
Noopept has a safety rating of "moderate". That is a category, not a measure of individual risk, and there are precautions worth knowing. Reported side effects are uncommon and include irritability, headache, insomnia. Use caution if any of these apply to you: Severe hypertension; Kidney or liver impairment.
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Reviewed by Dr. Baher Al Hakim · Last reviewed May 2026 · evidence from 13 studies · how we score · editorial policy
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.
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