We use essential cookies (authentication, your saved goals/stack) by default. With your permission we’ll also enable privacy-respecting analytics (Vercel Web Analytics, anonymous load-time metrics) and error-replay diagnostics (Sentry — DOM snapshots only when an error fires) so we can fix bugs faster. Learn more about cookies
Noopept (N-Phenylacetyl-L-prolylglycine ethyl ester)
Synthetic peptide ~1,000x more potent than piracetam; studied for memory and learning, with limited controlled human data.
Research compound — not a dietary supplement
Noopept is a research compound, not a regulated dietary supplement. It is sold for research or off-label use. The evidence below is largely preclinical (animal and in-vitro) or early-stage, so no evidence score is assigned. This page is provided for transparency and education — it is not a recommendation to use. Consult a qualified healthcare provider, and be aware that purity, dosing, and legal status vary by jurisdiction.
What the evidence says
Most Noopept studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from medium-quality randomised trials published 2007–2026 with a typical study size of 60 participants.
Based on 13 studies · 2 RCTs · 120 total participants
Confidence
Low confidenceBy outcome
Earns an Emerging 4: a small Russian RCT and mechanistic NGF/BDNF data are encouraging, but evidence is dominated by low-quality observational and preclinical studies, with no Western trials and no FDA approval.
Noopept is a synthetic nootropic peptide developed in Russia that is estimated to be 1000 times more potent than piracetam by weight. Despite being called a racetam by some, it has a different structure (dipeptide).
It rapidly crosses the blood-brain barrier and increases NGF and BDNF, supporting neuroplasticity and neuroprotection. Effects include improved memory consolidation, learning, and a mild psychostimulant effect.
Increases growth factors
Enhances glutamate signaling
Protects neurons from damage
How Noopept works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
Popular for studying and cognitive enhancement
Tip: Reduce dose
Tip: Add choline source
Tip: Avoid late doses
Noopept has an evidence score of 4/10 — emerging evidence based on 12 indexed studies. Synthetic peptide ~1,000x more potent than piracetam; studied for memory and learning, with limited controlled human data. Representative study: PMID 22500312.
The commonly studied dose of Noopept is 10-30mg daily in divided doses. Research points to an estimated optimal dose around 20mg, with a minimum effective dose near 10mg. Individual response varies — start low and adjust.
The best time to take Noopept is in the morning. Taking it with food is preferred. Noopept (N-phenylacetyl-L-prolylglycine ethyl ester) is a synthetic nootropic peptide with rapid onset.
Noopept is generally safe at recommended doses, with a few precautions worth noting. Reported side effects are uncommon and include irritability, headache, insomnia. Use caution if any of these apply to you: Severe hypertension; Kidney or liver impairment.
Huperzine A
Likely helpsAcetylcholinesterase inhibitor from club moss, studied mainly for Alzheimer's and dementia; cognitive evidence is mixed and limited by trial quality.
Phosphatidylserine
Mostly mechanism / observationalKey brain membrane phospholipid that facilitates neurotransmitter release, memory formation, and post-exercise cortisol reduction.
Alpha-GPC
Likely helpsCrosses the blood-brain barrier to fuel acetylcholine synthesis — supports focus, memory, and power output in athletes.
Citicoline
Probably helpsDual precursor to acetylcholine and phosphatidylcholine — enhances memory, focus, and brain cell membrane repair.
Explore: Best supplements for Focus, Memory & MoodBest supplements for Vitality & Longevity
Reviewed by Dr. Baher Al Hakim · Last reviewed May 2026 · evidence from 13 studies · how we score · editorial policy
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.
Tap node to isolate • Pinch to zoom • Tap edge for research