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Noopept (N-Phenylacetyl-L-prolylglycine ethyl ester)
Synthetic peptide ~1,000x more potent than piracetam that boosts NGF and BDNF for memory, learning, and neuroprotection.
What the evidence says
Most Noopept studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from medium-quality randomised trials published 2007–2023 with a typical study size of 60 participants.
Based on 12 studies · 3 RCTs · 530 total participants
Confidence
ModerateBy outcome
Noopept has an evidence score of 5.5/10 — moderate evidence based on 12 indexed studies. Synthetic peptide ~1,000x more potent than piracetam that boosts NGF and BDNF for memory, learning, and neuroprotection.
The commonly studied dose of Noopept is 10-30mg daily in divided doses. Research points to an estimated optimal dose around 20mg, with a minimum effective dose near 10mg. Individual response varies — start low and adjust.
The best time to take Noopept is in the morning. Taking it with food is preferred. Noopept (N-phenylacetyl-L-prolylglycine ethyl ester) is a synthetic nootropic peptide with rapid onset.
Phosphatidylserine
Mostly mechanism / observationalKey brain membrane phospholipid that facilitates neurotransmitter release, memory formation, and post-exercise cortisol reduction.
Huperzine A
Likely helpsInhibits acetylcholinesterase to raise acetylcholine levels, enhancing memory formation, focus, and learning capacity.
Last reviewed May 2026 · evidence from 12 studies · how we score
This information is for educational purposes only. It is not a substitute for professional medical advice. Always consult a qualified healthcare provider before starting, stopping, or changing any supplement or medication.
Noopept is a synthetic nootropic peptide developed in Russia that is estimated to be 1000 times more potent than piracetam by weight. Despite being called a racetam by some, it has a different structure (dipeptide). It rapidly crosses the blood-brain barrier and increases NGF and BDNF, supporting neuroplasticity and neuroprotection. Effects include improved memory consolidation, learning, and a mild psychostimulant effect.
Increases growth factors
Enhances glutamate signaling
Protects neurons from damage
How Noopept works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
Tap node to isolate • Pinch to zoom • Tap edge for research
10-30mg daily in divided doses
Loading: Not required; start at 10mg
Can be taken without food
| Form | Type |
|---|---|
| 💊Noopept powder (sublingual) or capsules | Recommended |
| 💨Noopept nasal spray | Alternative |
Powder for sublingual use offers faster absorption. Extremely potent - milligram scale needed for powder.
Minimum: 4 weeks
Optimal: 8 weeks
Cycling: 8-12 weeks on, 4 weeks off
Note: Very potent - accurate dosing crucial. Sublingual absorption is faster. Avoid evening doses due to mild stimulation.
Based on RCT with n=60 showing MMSE improvements after 2 months. Most studies lack placebo controls and have small sample sizes. Effectiveness may be overestimated due to study limitations.
Enhanced memory consolidation and learning
Improved focus and clarity of thought
Long-term brain health support
Can cause irritability in some users
Popular for studying and cognitive enhancement
Tip: Reduce dose
Tip: Add choline source
Tip: Avoid late doses
Noopept is generally safe at recommended doses, with a few precautions worth noting. The most commonly reported side effects are irritability, headache, insomnia. Use caution if any of these apply to you: Severe hypertension; Kidney or liver impairment.
Piracetam
Likely helpsFirst-ever nootropic (1972) that improves membrane fluidity and AMPA receptor function — decades of safety data for cognitive enhancement.