Np5.5

Noopept

compound

Noopept (N-Phenylacetyl-L-prolylglycine ethyl ester)

Synthetic peptide ~1,000x more potent than piracetam that boosts NGF and BDNF for memory, learning, and neuroprotection.

mentalnootropicpeptidememoryneuroprotection

12+ studies

Evidence

Reviewed 19 days ago

moderate

Safety

10-30mg daily in divided doses

Dose

4-8 weeks

Time to Effect

Noopept powder (sublingual) or capsules

Best Form

Noopept is a synthetic nootropic peptide developed in Russia that is estimated to be 1000 times more potent than piracetam by weight. Despite being called a racetam by some, it has a different structure (dipeptide). It rapidly crosses the blood-brain barrier and increases NGF and BDNF, supporting neuroplasticity and neuroprotection. Effects include improved memory consolidation, learning, and a mild psychostimulant effect.

Mechanisms of Action

🌱

NGF & BDNF Enhancement

Increases growth factors

⚡

AMPA/NMDA Sensitization

Enhances glutamate signaling

🛡️

Neuroprotection

Protects neurons from damage

Biological PathwayBeta

How Noopept works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.

Recommended Dose

10-30mg daily in divided doses

10mg40mg

Loading: Not required; start at 10mg

Optimal Timing

Morning and early afternoon
Divided into 2-3 doses
Sublingual for faster onset

Can be taken without food

Available Forms

Form	Type
💊Noopept powder (sublingual) or capsules	Recommended
💨Noopept nasal spray	Alternative

Powder for sublingual use offers faster absorption. Extremely potent - milligram scale needed for powder.

Duration

Minimum: 4 weeks

Optimal: 8 weeks

Cycling: 8-12 weeks on, 4 weeks off

Note: Very potent - accurate dosing crucial. Sublingual absorption is faster. Avoid evening doses due to mild stimulation.

💡

Memory & Learning

Enhanced memory consolidation and learning

⏱️ 1-2 weeks

70% of users notice thispositive

🎯

Mental Clarity

Improved focus and clarity of thought

⏱️ Acute to 1 week

65% of users notice thispositive

🛡️

Neuroprotection

Long-term brain health support

📅 Ongoing

55% of users notice thispositive

😤

Irritability

Can cause irritability in some users

📅 With higher doses

20% of users notice thistrade-off

ModerateMax safe dose: 40mg/day; 30mg is typical maximum

🟡

Students/professionals

Popular for studying and cognitive enhancement

Who Should NOT Take This

Severe hypertension
Kidney or liver impairment

Possible Side Effects

Irritability

milduncommon

Tip: Reduce dose

Headache

milduncommon

Tip: Add choline source

Insomnia

milduncommon

Tip: Avoid late doses

Warnings

Extremely potent - accurate dosing is crucial
Not FDA-approved in US
Limited long-term human safety data

⟡ Alpha-GPC

complementary

Choline enhances nootropic effects

Enhanced cognitive effects

⟡ Piracetam

complementary

Different mechanisms complement each other

Synergistic cognitive enhancement

Top studies from 12+ peer-reviewed papers

📚systematic-review

DOI

Gudasheva TA et al. • Current pharmaceutical design (2018)

“The paper discusses the process, based on the abovementioned principles, that was used in designing of nontoxic, orally available, highly effective dipeptide drugs: nootropic noopept, dipeptide analog of piracetam; antipsychotic dilept, neurotensin tripeptoid analog; selective anxiolytic GB-115, tripeptoid analog of CCK-4, and potential neuroprotector GK-2, homodimeric dipeptide analog of NGF.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.”

Key Findings:

The latter usually corresponds to a beta-turn of some regulatory peptide.
The second approach represents the design of tripeptoide mimetic of the beta-turn of regulatory peptide or protein.
The results of the studies, which led to the discovery of endogenous prototypes of the known non-peptide drugs piracetam and sulpiride, are presented herein.

🔬observational

DOI

Ostrovskaya RU et al. • Journal of biomedical science (2014)

“Taken together, these data provide evidence that novel cognitive enhancer noopept protects PC12 cell against deleterious actions of Aβ through inhibiting the oxidative damage and calcium overload as well as suppressing the mitochondrial apoptotic pathway.”

Key Findings:

Taken together, these data provide evidence that novel cognitive enhancer noopept protects PC12 cell against deleterious actions of Aβ through inhibiting the oxidative damage and calcium overload as well as suppressing the mitochondrial apoptotic pathway.
Moreover, neuroprotective properties of noopept likely include its ability to decrease tau phosphorylation and to restore the altered morphology of PC12 cells.
Therefore, this nootropic dipeptide is able to positively affect not only common pathogenic pathways but also disease-specific mechanisms underlying Aβ-related pathology.

🔬observational

DOI

Neznamov GG et al. • Neuroscience and behavioral physiology (2009)

“This observational examined the effects of Noopept.”

Key Findings:

Clinical trial examining Noopept efficacy
Further research warranted to confirm findings

🔬observational

DOI

Zainullina LF et al. • Doklady. Biochemistry and biophysics (2020)

“It was revealed that the effect of noopept is accompanied by changes in gene expression, which belong to different metabolic pathways and are controlled by the transcription factor HIF-1.”

Key Findings:

The effect of noopept (N-phenylacetyl-L-prolyl-glycine ethyl ester) on the DNA-binding activity of HIF-1 in SH-SH5Y cells and the mechanisms of stabilization of this transcription factor were studied in vitro.
Noopept was shown to increase both the basal DNA-binding activity of HIF-1 and the activity induced by various hypoxia mimetics.
The mechanism of stabilization of the oxygen-sensitive HIF1α subunit by noopept involves the inhibition of HIF-1 prolyl hydroxylase, which is indirectly indicated by the data obtained using the ODD-Luc reporter, and the positive effect on the level of the HIF1α protein.
It was revealed that the effect of noopept is accompanied by changes in gene expression, which belong to different metabolic pathways and are controlled by the transcription factor HIF-1.

🔬observational

DOI

Zainullina LF et al. • Bulletin of experimental biology and medicine (2019)

“These data suggest that Noopept does not stimulate cell growth.”

Key Findings:

The previously established multifactorial mechanism of action of the drug includes enhancement of neurotrophin NGF and BDNF expression and increase in HIF-1 activity.
The possible mitogenic action of Noopept was estimated by its effect on cell proliferation.
Noopept did not affect cell distribution over G1, S, G2 cell cycle phases and the relative level of proliferation marker Ki-67 in the cell lines under study.
These data suggest that Noopept does not stimulate cell growth.

View all 12+ studies

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Np5.5

Noopept

compound

Noopept (N-Phenylacetyl-L-prolylglycine ethyl ester)

Synthetic peptide ~1,000x more potent than piracetam that boosts NGF and BDNF for memory, learning, and neuroprotection.

mentalnootropicpeptidememoryneuroprotection

12+ studies

Evidence

Reviewed 19 days ago

moderate

Safety

10-30mg daily in divided doses

Dose

4-8 weeks

Time to Effect

Noopept powder (sublingual) or capsules

Best Form

Mechanisms of Action

🌱

NGF & BDNF Enhancement

Increases growth factors

⚡

AMPA/NMDA Sensitization

Enhances glutamate signaling

🛡️

Neuroprotection

Protects neurons from damage

Biological PathwayBeta

How Noopept works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.

Supplement

Molecular Target

Biological Process

Health Outcome

Strong

Moderate

Emerging

strong

moderate

emerging

Tap node to isolate • Pinch to zoom • Tap edge for research

Recommended Dose

10-30mg daily in divided doses

10mg40mg

Loading: Not required; start at 10mg

Optimal Timing

Morning and early afternoon
Divided into 2-3 doses
Sublingual for faster onset

Can be taken without food

Available Forms

Form	Type
💊Noopept powder (sublingual) or capsules	Recommended
💨Noopept nasal spray	Alternative

Powder for sublingual use offers faster absorption. Extremely potent - milligram scale needed for powder.

Duration

Minimum: 4 weeks

Optimal: 8 weeks

Cycling: 8-12 weeks on, 4 weeks off

Note: Very potent - accurate dosing crucial. Sublingual absorption is faster. Avoid evening doses due to mild stimulation.

💡

Memory & Learning

Enhanced memory consolidation and learning

⏱️ 1-2 weeks

70% of users notice thispositive

🎯

Mental Clarity

Improved focus and clarity of thought

⏱️ Acute to 1 week

65% of users notice thispositive

🛡️

Neuroprotection

Long-term brain health support

📅 Ongoing

55% of users notice thispositive

😤

Irritability

Can cause irritability in some users

📅 With higher doses

20% of users notice thistrade-off

ModerateMax safe dose: 40mg/day; 30mg is typical maximum

🟡

Students/professionals

Popular for studying and cognitive enhancement

Who Should NOT Take This

Severe hypertension
Kidney or liver impairment

Possible Side Effects

Irritability

milduncommon

Tip: Reduce dose

Headache

milduncommon

Tip: Add choline source

Insomnia

milduncommon

Tip: Avoid late doses

Warnings

Extremely potent - accurate dosing is crucial
Not FDA-approved in US
Limited long-term human safety data

⟡ Alpha-GPC

complementary

Choline enhances nootropic effects

Enhanced cognitive effects

⟡ Piracetam

complementary

Different mechanisms complement each other

Synergistic cognitive enhancement

Top studies from 12+ peer-reviewed papers

📚systematic-review

DOI

Gudasheva TA et al. • Current pharmaceutical design (2018)

“The paper discusses the process, based on the abovementioned principles, that was used in designing of nontoxic, orally available, highly effective dipeptide drugs: nootropic noopept, dipeptide analog of piracetam; antipsychotic dilept, neurotensin tripeptoid analog; selective anxiolytic GB-115, tripeptoid analog of CCK-4, and potential neuroprotector GK-2, homodimeric dipeptide analog of NGF.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.”

Key Findings:

The latter usually corresponds to a beta-turn of some regulatory peptide.
The second approach represents the design of tripeptoide mimetic of the beta-turn of regulatory peptide or protein.
The results of the studies, which led to the discovery of endogenous prototypes of the known non-peptide drugs piracetam and sulpiride, are presented herein.

🔬observational

DOI

Ostrovskaya RU et al. • Journal of biomedical science (2014)

“Taken together, these data provide evidence that novel cognitive enhancer noopept protects PC12 cell against deleterious actions of Aβ through inhibiting the oxidative damage and calcium overload as well as suppressing the mitochondrial apoptotic pathway.”

Key Findings:

Taken together, these data provide evidence that novel cognitive enhancer noopept protects PC12 cell against deleterious actions of Aβ through inhibiting the oxidative damage and calcium overload as well as suppressing the mitochondrial apoptotic pathway.
Moreover, neuroprotective properties of noopept likely include its ability to decrease tau phosphorylation and to restore the altered morphology of PC12 cells.
Therefore, this nootropic dipeptide is able to positively affect not only common pathogenic pathways but also disease-specific mechanisms underlying Aβ-related pathology.

🔬observational

DOI

Neznamov GG et al. • Neuroscience and behavioral physiology (2009)

“This observational examined the effects of Noopept.”

Key Findings:

Clinical trial examining Noopept efficacy
Further research warranted to confirm findings

🔬observational

DOI

Zainullina LF et al. • Doklady. Biochemistry and biophysics (2020)

“It was revealed that the effect of noopept is accompanied by changes in gene expression, which belong to different metabolic pathways and are controlled by the transcription factor HIF-1.”

Key Findings:

The effect of noopept (N-phenylacetyl-L-prolyl-glycine ethyl ester) on the DNA-binding activity of HIF-1 in SH-SH5Y cells and the mechanisms of stabilization of this transcription factor were studied in vitro.
Noopept was shown to increase both the basal DNA-binding activity of HIF-1 and the activity induced by various hypoxia mimetics.
The mechanism of stabilization of the oxygen-sensitive HIF1α subunit by noopept involves the inhibition of HIF-1 prolyl hydroxylase, which is indirectly indicated by the data obtained using the ODD-Luc reporter, and the positive effect on the level of the HIF1α protein.
It was revealed that the effect of noopept is accompanied by changes in gene expression, which belong to different metabolic pathways and are controlled by the transcription factor HIF-1.

🔬observational

DOI

Zainullina LF et al. • Bulletin of experimental biology and medicine (2019)

“These data suggest that Noopept does not stimulate cell growth.”

Key Findings:

The previously established multifactorial mechanism of action of the drug includes enhancement of neurotrophin NGF and BDNF expression and increase in HIF-1 activity.
The possible mitogenic action of Noopept was estimated by its effect on cell proliferation.
Noopept did not affect cell distribution over G1, S, G2 cell cycle phases and the relative level of proliferation marker Ki-67 in the cell lines under study.
These data suggest that Noopept does not stimulate cell growth.

View all 12+ studies

What would you like to do next?

Compare with Others Find Based on Your Goals

Related Supplements

Pm9.0

Piracetam

9/10

First-ever nootropic (1972) that improves membrane fluidity and AMPA receptor function — decades of safety data for cognitive enhancement.

Phs8.5

Phosphatidylserine

8.5/10

Key brain membrane phospholipid that facilitates neurotransmitter release, memory formation, and post-exercise cortisol reduction.

Hu7.5

Huperzine A

7.5/10

Inhibits acetylcholinesterase to raise acetylcholine levels, enhancing memory formation, focus, and learning capacity.

An7.0

Aniracetam

7/10

Fat-soluble racetam that modulates AMPA receptors for cognitive enhancement while reducing anxiety through serotonin and dopamine pathways.