Np5.5

Noopept Research

12 peer-reviewed studies · Evidence score: 5.5/10

Noopept as a Neuroprotective and Cognitive-Enhancing Agent: A Review of Preclinical and Clinical Evidence

Gudasheva TA et al. • CNS & Neurological Disorders Drug Targets (2020)

Noopept demonstrated cognitive enhancement and neuroprotective properties through BDNF and NGF upregulation.

Increases BDNF and NGF expression in hippocampus
Cognitive improvements observed in patients with mild cognitive impairment
Effective at doses 1000x lower than piracetam on a per-weight basis

Systematic Reviewn=410

DOI

Novel Technologies for Dipeptide Drugs Design and their Implantation

Gudasheva TA et al. • Current pharmaceutical design (2018)

The paper discusses the process, based on the abovementioned principles, that was used in designing of nontoxic, orally available, highly effective dipeptide drugs: nootropic noopept, dipeptide analog of piracetam; antipsychotic dilept, neurotensin tripeptoid analog; selective anxiolytic GB-115, tripeptoid analog of CCK-4, and potential neuroprotector GK-2, homodimeric dipeptide analog of NGF.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

The latter usually corresponds to a beta-turn of some regulatory peptide.
The second approach represents the design of tripeptoide mimetic of the beta-turn of regulatory peptide or protein.
The results of the studies, which led to the discovery of endogenous prototypes of the known non-peptide drugs piracetam and sulpiride, are presented herein.

Systematic Review

DOI

[Noopept in the treatment of mild cognitive impairment in patients with stroke]

Amelin AV et al. • Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (2011)

The results have demonstrated that noopept, used in dose 20 mg daily during 2 months, improves cognitive functions in stroke patients and has a high level of safety.

An analysis of MMSE scores and lateral and categorical associations revealed the significant improvement of cognitive functions after 2 months in patients of the main group compared to the controls.
Cognitive functions were assessed before and after treatment using neuropsychological tests.
The global assessment of efficacy revealed the mild improvement in the main group while no changes were found in the control group.

RCTn=60

[Clinical and electroencephalographic characteristic of noopept in patients with mild cognitive impairment of posttraumatic and vascular origin]

Bochkarev VK et al. • Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (2008)

The EEG changes in posttraumatic brain lesion were less typical.

The analysis of frequency and spatial structure of EEG changes reveals that noopept exerts a nonspecific activation and anxyolytic effect.
The differences in EEG changes depending on the brain pathology were found.
The EEG indices of nootropic effect of the drug were most obvious in cerebral vascular diseases.

RCT

[Meteoadaptogenic properties of peptide drugs in healthy volunteers]

Shabanov PD et al. • Eksperimental'naia i klinicheskaia farmakologiia (2007)

Therefore, all the drugs studied (vinpotropil, cortexin, noopept and dilept) can be recommended as the agents producing activation, support and recovery of the physical and psychological efficiency under rapidly changing environment conditions.

Noopept, affecting positively a psychological component of the functional state, can be used for rapid adaptation to both cold and hot climate.
In the hot climate, noopept also enhanced the physical work capacity.
Therefore, all the drugs studied (vinpotropil, cortexin, noopept and dilept) can be recommended as the agents producing activation, support and recovery of the physical and psychological efficiency under rapidly changing environment conditions.

RCT

Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation

Ostrovskaya RU et al. • Journal of biomedical science (2014)

Taken together, these data provide evidence that novel cognitive enhancer noopept protects PC12 cell against deleterious actions of Aβ through inhibiting the oxidative damage and calcium overload as well as suppressing the mitochondrial apoptotic pathway.

Taken together, these data provide evidence that novel cognitive enhancer noopept protects PC12 cell against deleterious actions of Aβ through inhibiting the oxidative damage and calcium overload as well as suppressing the mitochondrial apoptotic pathway.
Moreover, neuroprotective properties of noopept likely include its ability to decrease tau phosphorylation and to restore the altered morphology of PC12 cells.
Therefore, this nootropic dipeptide is able to positively affect not only common pathogenic pathways but also disease-specific mechanisms underlying Aβ-related pathology.

Observational

DOI

Cognitive Enhancer Noopept Activates Transcription Factor HIF-1

Zainullina LF et al. • Doklady. Biochemistry and biophysics (2020)

It was revealed that the effect of noopept is accompanied by changes in gene expression, which belong to different metabolic pathways and are controlled by the transcription factor HIF-1.

The effect of noopept (N-phenylacetyl-L-prolyl-glycine ethyl ester) on the DNA-binding activity of HIF-1 in SH-SH5Y cells and the mechanisms of stabilization of this transcription factor were studied in vitro.
Noopept was shown to increase both the basal DNA-binding activity of HIF-1 and the activity induced by various hypoxia mimetics.
The mechanism of stabilization of the oxygen-sensitive HIF1α subunit by noopept involves the inhibition of HIF-1 prolyl hydroxylase, which is indirectly indicated by the data obtained using the ODD-Luc reporter, and the positive effect on the level of the HIF1α protein.

Observational

DOI

Drug with Neuroprotective Properties Noopept Does Not Stimulate Cell Proliferation

Zainullina LF et al. • Bulletin of experimental biology and medicine (2019)

These data suggest that Noopept does not stimulate cell growth.

The previously established multifactorial mechanism of action of the drug includes enhancement of neurotrophin NGF and BDNF expression and increase in HIF-1 activity.
The possible mitogenic action of Noopept was estimated by its effect on cell proliferation.
Noopept did not affect cell distribution over G1, S, G2 cell cycle phases and the relative level of proliferation marker Ki-67 in the cell lines under study.

Observational

DOI

[Prevention of neuro- and cardiotoxic side effects of tuberculosis chemotherapy with noopept]

Mordyk AV et al. • Klinicheskaia meditsina (2009)

The treatment promoted functional normalization of vegetative nervous system and antioxidative systems, reduced manifestations of anxiety, decreased frequency of adverse neuro- and cardiotoxic responses to antituberculous drugs.

The study evaluated clinical efficiency of noopept used to prevent adverse side effects of antituberculous agents.
It included 60 patients with newly diagnosed respiratory tuberculosis.
Those in group 1 (n = 30) received 10 mg of noopept twice daily during the first month.

Observationaln=60

Comparative studies of Noopept and piracetam in the treatment of patients with mild cognitive disorders in organic brain diseases of vascular and traumatic origin

Neznamov GG et al. • Neuroscience and behavioral physiology (2009)

This observational examined the effects of Noopept.

Clinical trial examining Noopept efficacy
Further research warranted to confirm findings

Observational

DOI

[Efficacy of noopept in discirculatory encephalopathy]

Barantsevich ER et al. • Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (2009)

This observational examined the effects of Noopept.

Clinical trial examining Noopept efficacy
Further research warranted to confirm findings

Observational

[The using of noopept in treatment of neurasthenia]

Chutko LS et al. • Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (2008)

This observational examined the effects of Noopept.

Clinical trial examining Noopept efficacy
Further research warranted to confirm findings

Observational

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