42 peer-reviewed studies · Evidence score: 8.5/10
Anheyer M et al. • Journal of integrative and complementary medicine (2025)
Future well-designed, large-scale RCTs employing standardized methodologies are necessary to confirm these findings and to establish optimal treatment protocols for diverse patient populations (Inplasy protocol number: 202350038).
Frumuzachi O et al. • Critical reviews in food science and nutrition (2025)
Overall, the meta-analysis suggests that supplementation with OLE, HT, and TYR may beneficially impact some cardiometabolic parameters, though further studies are needed to confirm these findings.
Álvares AA et al. • Nutrition reviews (2024)
In the meta-analysis, fasting glycemia, as evaluated in studies using a low dose of OLE, showed a significant result favoring the control group.
Ussia S et al. • Nutrients (2025)
Despite these results, further multicenter clinical studies with a wider range of patients are required to confirm and better understand EVOO's effects on the prevention of cardiovascular risk.
Lv L et al. • Immunity, inflammation and disease (2025)
VNN1 represents a promising therapeutic target for modulating oxidative stress and immunometabolism in various diseases.
Aumeeruddy MZ et al. • Current medicinal chemistry (2021)
This review is the first to provide a compiled list of traditional medicinal plants used worldwide against diabetes.
Martin Z et al. • Clinical nutrition ESPEN (2022)
Evidence to guide the dietary management of GERD symptoms is limited in scope, quality, and feasibility.
Del Saz-Lara A et al. • Advances in nutrition (Bethesda, Md.) (2022)
We conclude that EVOO and its OOPCs can regulate gene expression by modifying epigenetic mechanisms that impact human pathophysiology.
Fabiani R • Food & function (2016)
Further investigations are necessary to clarify the real chemopreventive potential of olive oil secoiridoid phenols on humans performing intervention studies on populations at high cancer risk.
Lamti F et al. • Journal of hypertension (2025)
OLE can decrease 24-h BP, BPL, and diastolic BPV with improvement of lipid profile, systemic inflammation, and body weight in hypertensive patients.
Angelopoulos N et al. • Nutrients (2023)
Our results confirm the LDL-C-lowering properties of monacolin are clinically meaningful even in lower doses of 3 mg/day.
Wong RH et al. • Nutrients (2014)
Further dose-response evaluation of olive leaf, green coffee bean or beetroot extracts is required to confirm or refute the purported benefits.
Imperatrice M et al. • Nutrients (2024)
Further studies are needed to elucidate the mechanisms underlying the observed effects.
Pinckaers PJ et al. • The Journal of nutrition (2025)
Chronic OLE supplementation resulted in higher skeletal muscle fractional PDH activity in healthy, older males, which may impact resting energy metabolism.
Haidari F et al. • Nutrition, metabolism, and cardiovascular diseases : NMCD (2025)
Adding OLE to a hypocaloric diet improves oxidative stress more effectively compared with a hypocaloric diet alone in obese women.
Toulabi T et al. • Explore (New York, N.Y.) (2022)
The evidence from these trials suggests the OLE cream is superior in the healing of episodes of HSV-1 over the acyclovir cream.
Kinkela Devčić M et al. • International journal of molecular sciences (2025)
Further research is needed to explore its potential therapeutic benefits on oral health.
Roshani M et al. • Explore (New York, N.Y.) (2025)
Hydroalcoholic olive leaf extract effectively reduces pain and improves physical functioning in elderly patients with knee osteoarthritis, offering a promising complementary treatment option for managing osteoarthritis symptoms.
Leach MJ et al. • Complementary therapies in clinical practice (2025)
The ESOLED trial has provided preliminary evidence on the tolerability of OLE in adults with type 2 diabetes, but was inconclusive in determining whether OLE is effective at improving glycaemic control, insulin sensitivity, diabetes-related distress and quality of life.
Bender C et al. • Nutrients (2023)
As bioavailability of a compound is a fundamental prerequisite for its effect, these results promise a good potential of both food supplements for protection against oxidative stress and the consequent cardiovascular risk.