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Ole7.0
Olive Leaf Extract – Forschung
Hilft wahrscheinlich
77 begutachtete Studien
Was die Evidenz sagt
Hilft wahrscheinlich
Olive Leaf Extract scheint in 7 von 8 Studien mit messbaren Effekten zu helfen — die Evidenz tendiert klar ins Positive.
Die meiste Evidenz stammt aus hochwertigen Meta-Analysen und randomisierten Studien, veröffentlicht 1991–2026 mit einer typischen Studiengröße von 79 Teilnehmenden.
Basierend auf 77 Studien · 5 Meta-Analysen · 47 RCTs · 5,595 Teilnehmende insgesamt
Konfidenz
Hohe Konfidenz
Was die Studien gefunden haben
7geholfen1nicht geholfen· 69 weitere ohne bewertete Effektdaten
Nach Outcome
Heart & blood pressureModerate Blutdrucksenkung; die Wirkung auf die Blutfette ist uneinheitlich und inkonsistent · 4-8 weeks
Hilft wahrscheinlich59 Studien
InflammationModerate Blutdrucksenkung · 8 weeks
Hilft wahrscheinlich19 Studien
Glucose & metabolic
Überwiegend Mechanismus / Beobachtung11 Studien
Cholesterol & lipidsModerate Blutdrucksenkung; die Wirkung auf die Blutfette ist uneinheitlich und inkonsistent · 4-8 weeks
Hilft wahrscheinlich6 Studien
Immune supportVerbesserte Immunfunktion und antimikrobielle Aktivität · 2-4 weeks
Überwiegend Mechanismus / Beobachtung6 Studien
Weight management
Überwiegend Mechanismus / Beobachtung5 Studien
Women's healthKann zur Linderung von Wechseljahrsbeschwerden wie Hitzewallungen und Stimmungsschwankungen beitragen · 4-8 weeks
Überwiegend Mechanismus / Beobachtung4 Studien
Cold sores & HSV
Zu wenige bewertete Studien2 Studien
Joint pain & arthritis
Zu wenige bewertete Studien1 Studie
Digestive health
Zu wenige bewertete Studien1 Studie
Therapeutic & clinical
Zu wenige bewertete Studien1 Studie
Safety profile
Zu wenige bewertete Studien1 Studie
In Zahlen
Aus 33 Studien mit messbaren Effekten gezogen
Wahrscheinlich echte Effekte
50%
über Studien hinweg
Untersuchte Personen
5,595
typische Studie: 79 Personen
Stärkste Designs
52
5 gepoolt, 47 randomisiert
Zeigte Nutzen
88%
7/8 Studien
Wie lange Studien liefen
Unter einer Woche
1
1–3 Monate
1
Untersuchte Populationen
General population4
Patients with herpes labialis1
Patients for cardiovascular disease prevention1
GERD patients1
Aktives Forschungsgebiet
45 Studien in den letzten 5 Jahren · Neueste Meta-Analyse: 2026
199120082026
1Herpes labialis symptomsSystematische Übersichtn=1,250 · large study2025
Einfach gesagt: Future well-designed, large-scale RCTs employing standardized methodologies are necessary to confirm these findings and to establish optimal treatment protocols for diverse patient populations (Inplasy protocol number: 202350038).
Anheyer M et al. · Journal of integrative and complementary medicine (2025)
Lemon balm preparations consistently reduced pain intensity and swelling, with some studies also reporting a significant decrease in lesion size compared with placebo or acyclovir.
Olive leaf extract demonstrated a statistically significant faster improvement in symptoms and a shorter healing time compared with acyclovir.
Discussion: The findings indicate that topical herbal therapies may provide effective and well-tolerated alternatives or adjuncts to conventional antiviral treatments for herpes labialis.
Einfach gesagt: Overall, the meta-analysis suggests that supplementation with OLE, HT, and TYR may beneficially impact some cardiometabolic parameters, though further studies are needed to confirm these findings.
Frumuzachi O et al. · Critical reviews in food science and nutrition (2025)
Fourteen human intervention studies with 594 participants were included.
Subgroup analysis showed that, in certain contexts, interventions may be more beneficial for BMI <30, non-Mediterranean, and cardiometabolic disease individuals, while intervention compound, type of intervention, and duration might have differential effects regarding considered outcomes.
Overall, the meta-analysis suggests that supplementation with OLE, HT, and TYR may beneficially impact some cardiometabolic parameters, though further studies are needed to confirm these findings.
Einfach gesagt: Despite these results, further multicenter clinical studies with a wider range of patients are required to confirm and better understand EVOO's effects on the prevention of cardiovascular risk.
Ussia S et al. · Nutrients (2025)
The beneficial effect was attributed to the polyphenols contained in EVOO.
Indeed, EVOO supplementation as part of the Mediterranean diet could improve patients' quality of life in secondary prevention by demonstrating a positive correlation with the cardioprotective role of polyphenols.
Discussion: A balanced diet with VOO represents a simple yet potent method to counteract metabolic dysfunctions associated with CVD.
Einfach gesagt: We conclude that EVOO and its OOPCs can regulate gene expression by modifying epigenetic mechanisms that impact human pathophysiology.
Del Saz-Lara A et al. · Advances in nutrition (Bethesda, Md.) (2022)
We conclude that EVOO and its OOPCs can regulate gene expression by modifying epigenetic mechanisms that impact human pathophysiology.
A full elucidation of the epigenetic effects of EVOO and its OOPCs may contribute to developing different pharma-nutritional strategies that exploit them as epigenetic agents.
Einfach gesagt: Further investigations are necessary to clarify the real chemopreventive potential of olive oil secoiridoid phenols on humans performing intervention studies on populations at high cancer risk.
Fabiani R · Food & function (2016)
All human intervention trials have investigated the effects of olive oil phenols on DNA damage.
Among the five selected studies, three have shown a significant preventive effect on oxidative DNA damage in terms of reduction of 8-oxo-7,8-dihydro-2'-deoxyguanosine in urine, in mitochondria DNA of mononuclear cells and in lymphocyte DNA.
The other two studies failed to see an effect on the urinary excretion of either etheno-DNA adducts or oxidation products of guanine.
Einfach gesagt: Special attention is given to their mechanistic actions and therapeutic potential in the context of iron-related disorders.
Freitas SML et al. · Critical reviews in food science and nutrition (2026)
Emerging evidence suggests that these compounds influence the expression and activity of iron-regulatory proteins such as hepcidin, ferroportin (FPN), ferritin, transferrin, and divalent metal transporter 1 (DMT1).
Their biological effects are frequently attributed to antioxidant, metal-chelating, and anti-inflammatory properties.
This review provides a comprehensive overview of selected plant-derived bioactive compounds-curcumin, catechins, quercetin, resveratrol, sulforaphane, tannins, myricetin, apigenin, and oleuropein-and their roles in iron metabolism and homeostasis.
1424-hour systolic blood pressureRCTn=621 · large study2025
Einfach gesagt: OLE can decrease 24-h BP, BPL, and diastolic BPV with improvement of lipid profile, systemic inflammation, and body weight in hypertensive patients.
Lamti F et al. · Journal of hypertension (2025)
Spürbar Nutzen
← SchlechterKein EffektBesser →
Likely real
OLE significantly reduced 24-h SBP compared to baseline and placebo group [respectively -6.4 mmHg (95% confidence interval, 95% CI -10 to -2.1) and -1.5 mmHg (95% CI -3.9 to 0.51); P < 0.01].
In OLE group, systolic BPL decreased from 53.9% at baseline to 42.2% at 12-week ( P = 0.03); in placebo group, it did not change significantly ( P = 0.55).
Diastolic BPL decreased from 30.7 to 21.2% ( P = 0.03) in OLE group and did not change significantly in placebo group ( P = 0.12).
Einfach gesagt: Further dose-response evaluation of olive leaf, green coffee bean or beetroot extracts is required to confirm or refute the purported benefits.
Wong RH et al. · Nutrients (2014)
Baseline clinic BP in 37 overweight middle-aged men and women who completed the trial averaged 145/84 mmHg.
There was no significant effect of treatment on ABP or any other outcome measure.
The failure to confirm prior evidence of the antihypertensive benefits of these extracts emphasises the importance of placebo control and the value of ABP monitoring.