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5 peer-reviewed studies
What the evidence says
Most Pantethine studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from medium-quality randomised trials published 1982–2023 with a typical study size of 32 participants.
Based on 5 studies · 1 RCT · 32 total participants
Confidence
LowBy outcome
1 study in the last 5 years
An in-vitro study found pantethine reduced cholesterol biosynthesis in cultured human skin fibroblasts.
Ranganathan S et al. · Atherosclerosis (1982)
A study found pantethine altered lipid composition and cholesterol content in cells.
van Gijsel-Bonnello M et al. · J Cell Physiol (2015)
A study found pantethine inhibits cholesterol and fatty-acid synthesis.
Cighetti G et al. · J Lipid Res (1987)
An animal study found pantethine ameliorated recognition impairment in a disease model.
Chen J et al. · Mol Nutr Food Res (2023)
A triple-blind, placebo-controlled RCT (n=32) found pantethine (600–900 mg/day) significantly lowered total and LDL cholesterol over 16 weeks.
Evans M, Rumberger JA, et al. · Vascular Health and Risk Management (2014)