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Pt4.0
Pterostilbene Research
Mostly mechanism / observational
55 peer-reviewed studies
What the evidence says
Mostly mechanism / observational
Most Pterostilbene studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality randomised trials published 2005–2026 with a typical study size of 111 participants.
Based on 55 studies · 9 RCTs · 888 total participants
Confidence
Moderate confidence
What the studies found
1helped· 54 more without graded effect data
By outcome
Longevity & agingSirtuin activation and antioxidant protection · 3-6 months
In plain English: We evaluated the toxic effects of natural products and summarized the available clinical trials on NAD+ metabolism, as well as the recent advances in the therapeutic application of natural products targeting NAD+ metabolism, with the aim to provide new insights into the treatment of multiple disorders.
Guo C et al. · Phytomedicine : international journal of phytotherapy and phytopharmacology (2023)
In plain English: However, optimal dose, duration, mechanism, long-term safety, side effects, combination, elucidation of genomic interactions, and lifestyle modifications should be considered.
Özyalçın B et al. · Critical reviews in food science and nutrition (2024)
Stilbenes are products of the plant phenylpropanoid pathway.
Very important mechanisms for the anti-obesity impact belonging to resveratrol as well as pterostilbene include thermogenic activation in brown adipose tissue alongside the browning of white adipose tissue.
Considering nutrition and dietary habits, which have an important place in lifestyle changes for both the prevention and the treatment of obesity, pterostilbene and resveratrol, which are polyphenols and stilbenes, are seen as promising.
The anti-ageing mechanisms of resveratrol and its analogues are complex and multifactorial, involving suppressing oxidative stress, ameliorating inflammation, activating SIRT1 pathway, reducing DNA damage, etc.
In this chapter, the anti-ageing effects of resveratrol and its analogues are summarised with special attention paid to the underlying mechanisms.
Further understanding of these small molecules could provide the necessary scientific basis for their development into anti-ageing agents.
Fibrosis is a prevailing pathology in chronic diseases and accounts for 45% of deaths in developed countries.
As a result, PTS has the potential to prevent and cure numerous diseases.
In this review, we comprehensively summarize the antifibrotic effects of PTS both in vivo and in vitro and the pharmacological mechanisms, pharmacokinetics, and toxicology of PTS and provide insights into and strategies for exploring promising agents for the treatment of fibrosis.
7Vascular endothelial cell protection from oxidative stressReview2021
In plain English: Our present paper provides updated information of natural agents with protective activities on ECs against oxidative stress by activating Nrf2/HO-1.
Zhang Q et al. · Journal of advanced research (2021)
Our present paper provides updated information of natural agents with protective activities on ECs against oxidative stress by activating Nrf2/HO-1.
We hope this review will provide some directions for the further development of novel candidate drugs from natural agents for the treatment of AS and other CVDs.
Pan MH et al. · BioFactors (Oxford, England) (2018)
Resveratrol and pterostilbene are well-known stilbenes that provide various potential benefits to human health.
In particular, their potential anti-obesity effects have been proven in numerous cell culture and animal studies.
Both compounds act to regulate energy intake, adipocyte life cycle and function, white adipose tissue (WAT) inflammation, energy expenditure, and gut microbiota by targeting multiple molecules and signaling pathways as an intervention for obesity.
In plain English: For example, in vitro studies suggest that L-carnitine and pterostilbene, a blueberry component may reduce oxidative stress, and in animal studies, alpha-lipoic acid (ALP) and selenoprotein P may b...
Seen S et al. · Acta ophthalmologica (2018)
For example, in vitro studies suggest that L-carnitine and pterostilbene, a blueberry component may reduce oxidative stress, and in animal studies, alpha-lipoic acid (ALP) and selenoprotein P may be helpful.
Examples of treatments used in clinical trials include vitamin B12 eyedrops and iodide iontophoresis.
With recent emphasis on ageing medicine and preventive holistic health, as well as the role of environmental science, research on oxidative stress in the ocular surface is likely to have increasing impact in the coming years.
In plain English: Moreover, pterostilbene exhibits much greater bioavailability and bioactivity than resveratrol which warrants further investigation in the anti-cancer functions and mechanisms. .
Zhang X et al. · Zhongguo fei ai za zhi = Chinese journal of lung cancer (2018)
Pterostilbene (3,5-dimethoxy-4'-hydroxystilbene) is a polyphenolic compound primarily found in blueberries, grapes, and a tree wood, pterocarpus marsupium.
Studies demonstrate that pterostilbene inhibits a variety of cancers, such as lung, breast, stomach, colon, etc.
The anti-cancer activities are related to the regulation of several hallmarks of cancer.
11Metabolic effects of PterostilbeneReview2020
In plain English: This systematic-review examined the effects of Pterostilbene.
Kim H et al. · Journal of agricultural and food chemistry (2020)
Many of the extensive studies on the potential health benefits of pterostilbene were conducted by Dr.
Agnes Rimando, a scientist with the United States Department of Agriculture, in collaboration with many U.S. and other international research groups.
This review highlights the pterostilbene research of Dr.
In plain English: In this review, we summarize the current knowledge on the role of resveratrol and pterostilbene in improving brain health during aging, with specific focus on antioxidant and anti-inflammatory signaling and behavioral outcomes.
Poulose SM et al. · Neurochemistry international (2015)
Because approximately 25% of the world population is expected to be older than age 65 by 2050, and no treatments exist to halt or reverse ongoing neurodegeneration, the need for effective prevention strategies is more pressing that ever before.
A growing body of research supports the role of diet in healthy aging, particularly diets rich in bioactive phytochemical compounds.
Recently, stilbenes such as resveratrol (3, 5, 4'-trans-trihydroxystilbene) and its analogue, pterostilbene, have gained a significant amount of attention for their potent antioxidant, anti-inflammatory, and anticarcinogenic properties.
In plain English: Based on present evidences we conclude that pterostilbene is an active phytonutrient and also a potential drug with multiple biomedical applications.
Estrela JM et al. · Critical reviews in clinical laboratory sciences (2013)
Safety and toxicity, as well as recommendations for future research and biomedical uses, are discussed.
This review includes comparisons between pterostilbene and other polyphenols, with particular emphasis on resveratrol.
Potential benefits of using combinations of different polyphenols are considered.
15Antioxidant capacity induction in cancer cell linesReview2012
In plain English: Pterostilbene has also been shown to be effective as an inducer of antioxidant capacity in multiple cancer cell lines that may facilitate its function as an anticarcinogenic compound.
McCormack D et al. · The Journal of surgical research (2012)
Pterostilbene has also been shown to be effective as an inducer of antioxidant capacity in multiple cancer cell lines that may facilitate its function as an anticarcinogenic compound.
Additionally, preliminary studies show that pterostilbene exhibits much greater bioavailability compared with other stilbene compounds; however the exact pharmacologic mechanism of pterostilbene and its effects in humans are still under investigation.
In this review, we present a comprehensive summary of the antineoplastic mechanisms of pterostilbene based on the results of preclinical studies and highlight recent advances in the study of this dietary compound.Copyright Â
Li YR et al. · BioFactors (Oxford, England) (2018)
In this review, we discuss the relationship between resveratrol and pterostilbene and possible aging biomarker, including oxidative stress, inflammation, and high-calorie diets.
Moreover, we also discuss the positive effect of resveratrol and pterostilbene on lifespan, aged-related disease, and health maintenance.
Furthermore, we summarize a variety of important mechanisms modulated by resveratrol and pterostilbene possibly involved in attenuating age-associated disorders.
17Gut microbiota modulation for cardiovascular diseaseReview2019
In plain English: Herbal medicine (HM) plays a role in modulating gut microbiota and is widely used in the prevention and treatment of cardiovascular disease (CVD) and its associated conditions, such as diabetes, ob...
Anlu W et al. · Pharmacological research (2019)
Herbal medicine (HM) plays a role in modulating gut microbiota and is widely used in the prevention and treatment of cardiovascular disease (CVD) and its associated conditions, such as diabetes, obesity, and hyperlipidemia.
In this review, we focus on the relationship between the microbiota-metabolism-immunity (MMI) axis and CVD (including its risk factors) and the beneficial effects of HM to regulate this crosstalk.
The insights may redefine our understanding of how HM works and spark a revolution in HM-based drug discovery.
In plain English: It is argued that the concentration of stilbenoids in food and beverages is too low to have any therapeutic potential and this concentration is further reduced by their low bioavailability and exte...
Dvorakova M et al. · Pharmacological research (2017)
It is argued that the concentration of stilbenoids in food and beverages is too low to have any therapeutic potential and this concentration is further reduced by their low bioavailability and extensive metabolism.
Moreover, the ways to augment stilbenoidś efficacy are suggested with special focus on multitargeted therapy and nanocarriers.
In plain English: Therefore, further research is warranted to evaluate the salutary effects of various stilbenoids.
Akinwumi BC et al. · International journal of molecular sciences (2018)
Although positive results were obtained in most cell culture and animal studies, further human studies are needed to substantiate beneficial effects of stilbenoids.
Resveratrol remains the most widely studied stilbenoid.
However, there is limited information regarding the potential of less common stilbenoids.
In plain English: Recently, stilbenes have attracted extensive attention and interest due to their wide range of health-beneficial effects such as anti-inflammation, -carcinogenic, -diabetes, and -dyslipidemia activ...
Tsai HY et al. · Journal of food and drug analysis (2017)
Recently, stilbenes have attracted extensive attention and interest due to their wide range of health-beneficial effects such as anti-inflammation, -carcinogenic, -diabetes, and -dyslipidemia activities.
Moreover, accumulating in vitro and in vivo studies have reported that stilbene compounds act as inducers of multiple cell-death pathways such as apoptosis, cell cycle arrest, and autophagy for chemopreventive and chemotherapeutic agents in several types of cancer cells.
The aim of this review is to highlight recent molecular findings and biological actions of trans-resveratrol, pterostilbene, and 3'-hydroxypterostilbene.