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Pt7.0
Pterostilbene Research
Mostly mechanism / observationalHigh safety
37 peer-reviewed studies
What the evidence says
Mostly mechanism / observational
Most Pterostilbene studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 2005–2026 with a typical study size of 60 participants.
Based on 37 studies · 1 meta-analysis · 9 RCTs · 918 total participants
Confidence
Moderate
What the studies found
1helped· 36 more without graded effect data
By outcome
Longevity & agingSirtuin activation and antioxidant protection · 3-6 months
The anti-ageing mechanisms of resveratrol and its analogues are complex and multifactorial, involving suppressing oxidative stress, ameliorating inflammation, activating SIRT1 pathway, reducing DNA damage, etc.
In this chapter, the anti-ageing effects of resveratrol and its analogues are summarised with special attention paid to the underlying mechanisms.
Further understanding of these small molecules could provide the necessary scientific basis for their development into anti-ageing agents.
However, optimal dose, duration, mechanism, long-term safety, side effects, combination, elucidation of genomic interactions, and lifestyle modifications should be considered.
Özyalçın B et al. · Critical reviews in food science and nutrition (2024)
Stilbenes are products of the plant phenylpropanoid pathway.
Very important mechanisms for the anti-obesity impact belonging to resveratrol as well as pterostilbene include thermogenic activation in brown adipose tissue alongside the browning of white adipose tissue.
Considering nutrition and dietary habits, which have an important place in lifestyle changes for both the prevention and the treatment of obesity, pterostilbene and resveratrol, which are polyphenols and stilbenes, are seen as promising.
Fibrosis is a prevailing pathology in chronic diseases and accounts for 45% of deaths in developed countries.
As a result, PTS has the potential to prevent and cure numerous diseases.
In this review, we comprehensively summarize the antifibrotic effects of PTS both in vivo and in vitro and the pharmacological mechanisms, pharmacokinetics, and toxicology of PTS and provide insights into and strategies for exploring promising agents for the treatment of fibrosis.
We evaluated the toxic effects of natural products and summarized the available clinical trials on NAD+ metabolism, as well as the recent advances in the therapeutic application of natural products targeting NAD+ metabolism, with the aim to provide new insights into the treatment of multiple disorders.
Guo C et al. · Phytomedicine : international journal of phytotherapy and phytopharmacology (2023)
7Endothelial cell protection from oxidative stress via Nrf2/HO-1 activationSystematic ReviewCited 656×2021
Our present paper provides updated information of natural agents with protective activities on ECs against oxidative stress by activating Nrf2/HO-1.
Zhang Q et al. · Journal of advanced research (2021)
Our present paper provides updated information of natural agents with protective activities on ECs against oxidative stress by activating Nrf2/HO-1.
We hope this review will provide some directions for the further development of novel candidate drugs from natural agents for the treatment of AS and other CVDs.
Therefore, further research is warranted to evaluate the salutary effects of various stilbenoids.
Akinwumi BC et al. · International journal of molecular sciences (2018)
Although positive results were obtained in most cell culture and animal studies, further human studies are needed to substantiate beneficial effects of stilbenoids.
Resveratrol remains the most widely studied stilbenoid.
However, there is limited information regarding the potential of less common stilbenoids.
11Anti-inflammatory and anticancer effectsSystematic ReviewCited 96×2020
We also summarize recent research on pterostilbene's anti-inflammatory and anticancer properties in the multistage carcinogenesis process and related molecular mechanism and conclude that it should contribute to improved cancer management.
Lin WS et al. · Journal of agricultural and food chemistry (2020)
In this review, we illustrate that pterostilbene is a natural compound having bioavailability.
The extensive metabolism of pterostilbene will be discussed.
We also summarize recent research on pterostilbene's anti-inflammatory and anticancer properties in the multistage carcinogenesis process and related molecular mechanism and conclude that it should contribute to improved cancer management.
12Gut microbiota modulation for cardiovascular diseaseSystematic ReviewCited 30×2019
Herbal medicine (HM) plays a role in modulating gut microbiota and is widely used in the prevention and treatment of cardiovascular disease (CVD) and its associated conditions, such as diabetes, ob...
Anlu W et al. · Pharmacological research (2019)
Herbal medicine (HM) plays a role in modulating gut microbiota and is widely used in the prevention and treatment of cardiovascular disease (CVD) and its associated conditions, such as diabetes, obesity, and hyperlipidemia.
In this review, we focus on the relationship between the microbiota-metabolism-immunity (MMI) axis and CVD (including its risk factors) and the beneficial effects of HM to regulate this crosstalk.
The insights may redefine our understanding of how HM works and spark a revolution in HM-based drug discovery.
Li YR et al. · BioFactors (Oxford, England) (2018)
In this review, we discuss the relationship between resveratrol and pterostilbene and possible aging biomarker, including oxidative stress, inflammation, and high-calorie diets.
Moreover, we also discuss the positive effect of resveratrol and pterostilbene on lifespan, aged-related disease, and health maintenance.
Furthermore, we summarize a variety of important mechanisms modulated by resveratrol and pterostilbene possibly involved in attenuating age-associated disorders.
Lange KW et al. · BioFactors (Oxford, England) (2018)
In comparison to resveratrol, pterostilbene appears to be more effective in combatting brain changes associated with aging.
This may be attributed to the more lipophilic nature of pterostilbene with its two methoxyl groups compared with the two hydroxyl groups of resveratrol.
The findings of available intervention trials of resveratrol in individuals with mild cognitive impairment or AD do not provide evidence of neuroprotective or therapeutic effects.
Wang P et al. · BioFactors (Oxford, England) (2018)
Resveratrol and pterostilbene exhibit many pharmacological similarities and both of them are generally considered to be safe for human consumption.
Beyond the structural and general bioactivity similarities between them, large amounts of data are now available to reveal the metabolic fate and pharmacological differences between them.
Moreover, pterostilbene exhibits much greater bioavailability and bioactivity than resveratrol which warrants further investigation in the anti-cancer functions and mechanisms. .
Zhang X et al. · Zhongguo fei ai za zhi = Chinese journal of lung cancer (2018)
Pterostilbene (3,5-dimethoxy-4'-hydroxystilbene) is a polyphenolic compound primarily found in blueberries, grapes, and a tree wood, pterocarpus marsupium.
Studies demonstrate that pterostilbene inhibits a variety of cancers, such as lung, breast, stomach, colon, etc.
The anti-cancer activities are related to the regulation of several hallmarks of cancer.
17Systematic ReviewCited 266×2018
For example, in vitro studies suggest that L-carnitine and pterostilbene, a blueberry component may reduce oxidative stress, and in animal studies, alpha-lipoic acid (ALP) and selenoprotein P may b...
Seen S et al. · Acta ophthalmologica (2018)
For example, in vitro studies suggest that L-carnitine and pterostilbene, a blueberry component may reduce oxidative stress, and in animal studies, alpha-lipoic acid (ALP) and selenoprotein P may be helpful.
Examples of treatments used in clinical trials include vitamin B12 eyedrops and iodide iontophoresis.
With recent emphasis on ageing medicine and preventive holistic health, as well as the role of environmental science, research on oxidative stress in the ocular surface is likely to have increasing impact in the coming years.
Pan MH et al. · BioFactors (Oxford, England) (2018)
Resveratrol and pterostilbene are well-known stilbenes that provide various potential benefits to human health.
In particular, their potential anti-obesity effects have been proven in numerous cell culture and animal studies.
Both compounds act to regulate energy intake, adipocyte life cycle and function, white adipose tissue (WAT) inflammation, energy expenditure, and gut microbiota by targeting multiple molecules and signaling pathways as an intervention for obesity.
Lee PS et al. · BioFactors (Oxford, England) (2018)
Resveratrol and pterostilbene are stilbenoids, which have been reported to have anti-cancer, anti-inflammatory, anti-lipid, and anti-diabetic properties.
Stilbenoids are also reported to improve cardiovascular disease.
By altering DNA methylation and histone modification or by modulating miRNA expression, resveratrol, and pterostilbene become potent epigenetic modifiers.