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Qrc8.0
Quercetin Research
Likely helpsHigh safety
58 peer-reviewed studies
What the evidence says
Likely helps
Quercetin appears to help in 11 of 12 studies with measurable effects — the evidence leans clearly favourable.
Most evidence is from high-quality meta-analyses and randomised trials published 2008–2026 with a typical study size of 36 participants.
Based on 58 studies · 19 meta-analyses · 10 RCTs · 904,683 total participants
Confidence
High
What the studies found
11helped1unclear· 46 more without graded effect data
Women's healthMay help manage menopausal symptoms like hot flashes and mood changes · 4-8 weeks · Supports healthy estrogen metabolism and hormonal equilibrium · 4-8 weeks
Mostly mechanism / observational3 studies
Recovery
Too few graded studies1 study
Men's vitality
Too few graded studies1 study
By the numbers
Pulled from 46 studies with measurable effects
Likely real effects
60%
across studies
People studied
905k
typical study: 36 people
Strongest designs
29
19 pooled, 10 randomised
Showed benefit
92%
11/12 studies
How long studies ran
1–4 weeks
1
1–3 months
5
3+ months
2
Populations Studied
Humans4
General population3
COVID-19 patients2
Idiopathic pulmonary fibrosis patients2
Active research area
47 studies in the last 5 years · Latest meta-analysis: 2026
200820172026
1Tyrosinase inhibition and melanin reductionMeta-AnalysisCited 14×n=1,398 · large study2025
Okselni T et al. · Naunyn-Schmiedeberg's archives of pharmacology (2025)
Noticeable benefit
← WorseNo effectBetter →
Furthermore, quercetin significantly inhibited tyrosinase activity (Z-score, 1.95), resulting in a significantly reduced melanin content (Z-score, 2.56).
A significant reduction in DNA damage (Z-score, 3.27), melanoma cell viability (Z-score, 2.97), and tumor formation was also observed to ensure the promising activity of quercetin for skin issues.
This review highlights quercetin's potential as a multifaceted agent in skin care and treatment.
2COPD management outcomesMeta-AnalysisCited 2×n=894 · large study2025
This systematic review confirms that the efficacy of dietary polyphenols is significantly composition-specific.
Wu D et al. · Frontiers in immunology (2025)
This systematic review confirms that the efficacy of dietary polyphenols is significantly composition-specific.
Curcumin and salidroside can improve the course of COPD by regulating blood pressure, inflammation, and the coagulation pathway, supporting the hypothesis of "polyphenol targeting of metabolic-inflammatory networks".
However, the possible negative effects of anthocyanins warn against ingredient heterogeneity.
4ADHD symptom improvement with antioxidantsMeta-AnalysisCited 5×n=3,650 · very large study2024
The rankings of safety and efficacy of the 12 antioxidants vary.
Zhou P et al. · PloS one (2024)
The rankings of safety and efficacy of the 12 antioxidants vary.
Due to the low methodological quality of the included studies, the probability ranking cannot fully explain the clinical efficacy, and the results need to be interpreted with caution.
More high-quality studies are still needed to verify our findings.
7Systematic ReviewCited 15×n=269 · medium study2024
Heat-clearing herbs are useful and promising for the protection against and prevention of ischemic encephalopathy.
Zhao A et al. · Annals of medicine (2024)
Heat-clearing herbs are useful and promising for the protection against and prevention of ischemic encephalopathy.
It can be seen that the components of heat-clearing Chinese medicines can exert cerebroprotective effects through multiple pathways, which provides us with a reference for further development and study of heat-clearing Chinese medicines in the treatment of ischemic cerebrovascular diseases.
8Systolic blood pressureMeta-AnalysisCited 76×n=896 · large study2020
Quercetin intake resulted in significantly decreased BP in humans.
Huang H et al. · Nutrition reviews (2020)
Noticeable benefit
← WorseNo effectBetter →
Likely real
Pooled results showed that quercetin significantly lowered both systolic BP (WMD, -3.09 mmHg; 95%CI, -4.59 to -1.59; P = 0.0001) and diastolic BP (WMD, -2.86 mmHg; 95%CI, -5.09 to -0.63; P = 0.01).
Quercetin intake resulted in significantly decreased BP in humans.
Moreover, participants who consumed quercetin for 8 weeks or more showed significantly changed levels of high-density lipoprotein cholesterol and triglycerides in trials with a parallel design.
9Quercetin bioavailabilityMeta-AnalysisCited 29×n=31 · small study2025
This review summarises key factors that enhance quercetin bioavailability, contributing to the development of more effective and practical quercetin supplements or functional foods for better bioac...
Liu L et al. · Food chemistry (2025)
This review summarises key factors that enhance quercetin bioavailability, contributing to the development of more effective and practical quercetin supplements or functional foods for better bioactivity of quercetin in humans.
11Ovarian function outcomesSystematic ReviewCited 6×2025
This review underscores the potential of quercetin as a promising therapeutic agent for managing ovarian-related reproductive disorders.
Zhang X et al. · Phytomedicine : international journal of phytotherapy and phytopharmacology (2025)
This review underscores the potential of quercetin as a promising therapeutic agent for managing ovarian-related reproductive disorders.
Given its diverse biological activities, quercetin may offer significant clinical benefits in female reproductive medicine.
Nonetheless, further investigations are warranted to determine its long-term efficacy, optimal dosing strategies, and specific molecular targets across various ovarian pathologies.
12Digestive inflammatory cancer preventionMeta-AnalysisCited 34×2024
The discovery of the beneficial effects of these natural active compounds in POL supports the idea that POL could be a promising novel candidate for the treatment and prevention of inflammation-related cancers of the digestive system.
Shao G et al. · Journal of ethnopharmacology (2024)
The discovery of the beneficial effects of these natural active compounds in POL supports the idea that POL could be a promising novel candidate for the treatment and prevention of inflammation-related cancers of the digestive system.
However, clinical data describing the mode of action of the naturally active compounds of POL are still lacking.
In addition, pharmacokinetic data for POL compounds, such as changes in drug dose and absorption rates, cannot be extrapolated from animal models and need to be measured in patients in clinical trials.
13Bone metabolism improvementSystematic ReviewCited 98×n=36 · small study2022
The investigated phenolic compounds seem to positively mediate bone metabolism and osteoclast-related pathologies.
Inchingolo AD et al. · Nutrients (2022)
The studies reported the positive effects of the investigated phenolic compounds on bone metabolism and their potential application as adjuvant treatments for osteoporosis, bone tumours, and periodontitis.
Furthermore, their use on the titanium surfaces of orthopaedic prostheses could represent a possible application to improve the osteogenic processes and osseointegration.
According to the study findings, resveratrol, curcumin, and quercetin are reported to have a wide variety of beneficial effects as supplement therapies.
14Plasma lipid profilesMeta-AnalysisCited 78×n=442 · medium study2017
Available evidence from RCTs does not suggest any clinically relevant effect of quercetin supplementation on plasma lipids, apart from a significant reduction of triglycerides at doses above 50 mg/day.
Sahebkar A · Critical reviews in food science and nutrition (2017)
No clear effect
← WorseNo effectBetter →
Could be chance
Combined estimate of effect size for the impact of quercetin on plasma LDL-C (WMD: 1.43 mg/dL, 95% CI: -0.92-3.78, p = 0.23), HDL-C (WMD: 0.26 mg/dL, 95% CI: -0.74-1.25, p = 0.61) and triglycerides (WMD: -9.42 mg/dL, 95% CI: -27.80-8.96, p = 0.32) was not statistically significant.
However, a borderline significant but clinically non-relevant increase in total cholesterol was observed (WMD: 3.13 mg/dL, 95% CI: -0.01-6.27, p = 0.05).
Changes in plasma triglycerides, but not other indices of lipid profile, were significantly associated with quercetin dose (slope: -0.057; 95% CI: -0.103 to -0.010; p = 0.02) and duration of supplementation (slope: -5.314; 95% CI: -9.482 to -1.147; p = 0.01).
However, future clinical studies are necessary to determine the real efficacy of these compounds in human endometriosis.
Hipólito-Reis M et al. · Phytotherapy research : PTR (2022)
Thirty articles, including a clinical trial, were included.
For the assessment of the quality of the selected studies that globally have "good quality", the GRADE (Grading of Recommendations Assessment, Development and Evaluation) and the SYRCLE ROB tool criteria were used.
However, future clinical studies are necessary to determine the real efficacy of these compounds in human endometriosis.
Although the effect size may be overestimated because of the quality of studies and possible publication bias, these results indicated that quercetin might be a promising neuroprotective agent for ...
Guo C et al. · Oxidative medicine and cellular longevity (2022)
Although the effect size may be overestimated because of the quality of studies and possible publication bias, these results indicated that quercetin might be a promising neuroprotective agent for human ischemic stroke.
The mechanisms of quercetin against focal cerebral ischemia are diverse, involving antioxidation, antiapoptotic, anti-inflammation, and calcium overload reduction.
On the whole, the present study suggested that quercetin can exert a protective effect on experimental ischemic stroke.
17Kidney stone prevention and managementMeta-AnalysisCited 108×2018
Further investigations are required to confirm the safety and efficacy of these compounds.
Nirumand MC et al. · International journal of molecular sciences (2018)
The main underlying mechanisms of these dietary plants and their isolated phytonutrients in the management of urolithiasis include diuretic, antispasmodic, and antioxidant activity, as well as an inhibitory effect on crystallization, nucleation, and aggregation of crystals.
The results as presented in this review demonstrate the promising role of dietary plants and phytophenols in the prevention and management of kidney stones.
Further investigations are required to confirm the safety and efficacy of these compounds.
18Disease Activity Score in Rheumatoid ArthritisSystematic ReviewCited 50×n=27 · very small study2020
In conclusion, RCT studies on diet or dietary supplements are limited in patients with RA, but based on the results in this review there is evidence that some interventions might have positive effects on DAS28.
Nelson J et al. · Nutrients (2020)
A total of 27 articles were included-three of whole diets (Mediterranean diet, raw food and anti-inflammatory diet), five of food items, five of n-3 fatty acids, five of single micronutrient supplements, four of single antioxidant supplements and five of pre-, pro- or synbiotics.
Studies that showed moderate strength evidence for positive effects on disease activity in RA included interventions with a Mediterranean diet, spices (ginger powder, cinnamon powder, saffron), antioxidants (quercetin and ubiquinone), and probiotics containing Lactobacillus Casei.
Other diets or supplements had either no effects or low to very low strength of evidence.
In summary, subgroup analysis based on duration of ≥8 weeks and used quercetin in dosages of ≥500 mg/day significantly reduced FPG levels.
Ostadmohammadi V et al. · Phytotherapy research : PTR (2019)
Nine studies with 10 effect sizes out of 357 selected reports were identified eligible to be included in current meta-analysis.
In summary, subgroup analysis based on duration of ≥8 weeks and used quercetin in dosages of ≥500 mg/day significantly reduced FPG levels.
The pooled findings indicated that quercetin supplementation did not affect fasting plasma glucose (FPG), homeostasis model of assessment-estimated insulin resistance, and hemoglobin A1c levels.
In this systematic review, we present information relating to the effectiveness and safety of the following interventions: 5 alpha-reductase inhibitors, allopurinol, alpha-blockers, biofeedback, local injections of antimicrobial drugs, mepartricin, non-steroidal anti-inflammatory drugs (NSAIDs), oral antimicrobial drugs, pentosan polysulfate, prostatic massage, quercetin, radical prostatectomy, sitz baths, transurethral microwave thermotherapy, and transurethral resection.