We use essential cookies (authentication, your saved goals/stack) by default. With your permission we’ll also enable privacy-respecting analytics (Vercel Web Analytics, anonymous load-time metrics) and error-replay diagnostics (Sentry — DOM snapshots only when an error fires) so we can fix bugs faster. Learn more about cookies
Qrc5.0
Quercetin Research
Likely helps
259 peer-reviewed studies
What the evidence says
Likely helps
Quercetin appears to help in 3 of 4 studies with measurable effects — the evidence leans clearly favourable.
Most evidence is from high-quality meta-analyses and randomised trials published 1993–2026 with a typical study size of 442 participants.
Based on 259 studies · 31 meta-analyses · 154 RCTs · 894,119 total participants
Confidence
High confidence
What the studies found
3helped1unclear· 255 more without graded effect data
By outcome
Heart & blood pressureLowers systolic blood pressure by about 2 to 3 mmHg in pooled trials, mostly at 500 mg a day or more · 4-8 weeks
Likely helps215 studies
Safety profile
Too few graded studies29 studies
InflammationSmall and inconsistent changes in inflammatory markers, no trial of inflammation-related symptoms · 4-8 weeks
Too few graded studies27 studies
Therapeutic & clinical
Too few graded studies27 studies
Longevity & agingSenolytic interest rests on trials of dasatinib plus quercetin, not quercetin alone · Ongoing
Too few graded studies15 studies
Glucose & metabolic
Too few graded studies12 studies
Immune supportNo effect on respiratory infections in the largest trial (1,002 people), a benefit appeared only in fit adults over 40 and in cyclists after hard training · 2-4 weeks
Too few graded studies9 studies
Recovery
Too few graded studies8 studies
Women's healthTwo PCOS trials (84 and 78 women) found small drops in testosterone and LH · 4-8 weeks
Too few graded studies8 studies
Endurance & exercise performance
Too few graded studies7 studies
Cognitive function
Too few graded studies7 studies
Cholesterol & lipidsLowers systolic blood pressure by about 2 to 3 mmHg in pooled trials, mostly at 500 mg a day or more · 4-8 weeks
Too few graded studies6 studies
Depression & mood
Too few graded studies4 studies
Liver health
Too few graded studies3 studies
Men's vitality
Too few graded studies2 studies
By the numbers
Pulled from 45 studies with measurable effects
Likely real effects
50%
across studies
People studied
894k
typical study: 442 people
Strongest designs
185
31 pooled, 154 randomised
Showed benefit
75%
3/4 studies
How long studies ran
1–4 weeks
2
1–3 months
4
3+ months
1
Populations Studied
Humans4
General population3
Skin conditions1
Rheumatoid arthritis patients1
Active research area
104 studies in the last 5 years · Latest meta-analysis: 2026
199320092026
1Tyrosinase inhibition and melanin reductionMeta-AnalysisCited 23×2025
In plain English: This review highlights quercetin's potential as a multifaceted agent in skin care and treatment.
Okselni T et al. · Naunyn-Schmiedeberg's archives of pharmacology (2025)
Of 1,398 studies identified, 65 met the criteria for meta-analysis. The abstract reports laboratory endpoints (oxidative-stress markers, cytokines, tyrosinase, melanoma cell viability) and no human clinical trial.
Quercetin significantly lowered MDA, ROS and LPO and raised GSH, CAT and SOD, and suppressed inflammatory cytokines including TNFα, IL-6 and IL-1β.
Furthermore, quercetin significantly inhibited tyrosinase activity (Z-score, 1.95), resulting in a significantly reduced melanin content (Z-score, 2.56).
2DAS28 improvementMeta-AnalysisCited 44×n=3,852 · very large study2023
In plain English: Dietary polyphenols may improve DAS28, reduce C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), and improve oxidative stress, etc.
Long Z et al. · Frontiers in immunology (2023)
47 RCTs with 3852 participants covered 15 dietary polyphenols. Quercetin was tested in 2 RCTs.
Dietary polyphenols may improve DAS28, reduce C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), and improve oxidative stress, etc.
The addition of dietary polyphenols did not increase adverse events.
3ADHD symptom improvementMeta-AnalysisCited 6×n=3,650 · very large study2024
In plain English: The rankings of safety and efficacy of the 12 antioxidants vary.
Zhou P et al. · PloS one (2024)
48 studies of 12 antioxidants with 3,650 children and adolescents with ADHD were included.
Quercetin ranked among the three safest agents (SUCRA 0.24), but was not among the most effective on any rating scale.
Due to the low methodological quality of the included studies, the probability ranking cannot fully explain the clinical efficacy, and the results need to be interpreted with caution.
4COPD improvementMeta-AnalysisCited 6×n=894 · large study2025
In plain English: Other polyphenols (quercetin, pomegranate juice, AKL1, etc.) did not show significant efficacy or insufficient evidence.
Wu D et al. · Frontiers in immunology (2025)
RCTs of eight polyphenols (curcumin, resveratrol, anthocyanins, quercetin, salidroside, beetroot juice, pomegranate juice, AKL1) in 894 COPD patients were included.
Quercetin, pomegranate juice and AKL1 did not show significant efficacy or had insufficient evidence.
Curcumin improved FEV1 and blood pressure, salidroside reduced thrombotic and inflammatory markers, and anthocyanins may accelerate lung function decline.
In plain English: From the data extracted, it was found that quercetin, Kaempferol, Rosmarinic acid, Cyanidin, Rutin, Catechin, Luteolin and Ellagic acid were the most cited bioactive compounds which all falls within the class of polyphenolic compounds.
Egbuna C et al. · Current topics in medicinal chemistry (2021)
A total of 6464 articles were identified, of which 84 were eligible.
Quercetin was among the most cited bioactive compounds reported to act against type 2 diabetes.
The abstract ranks compounds by how often they are cited and reports no clinical efficacy result for quercetin.
In plain English: This systematic review evaluated a total of 31 included human intervention studies that have assessed methods to improve quercetin bioavailability from different formulations and food matrices using urine or blood samples up to July 2024.
Liu L et al. · Food chemistry (2025)
A total of 31 human intervention studies were included.
Quercetin-3-O-oligoglucosides showed about 20-fold higher bioavailability than quercetin aglycone.
Lecithin phytosome formulations raised bioavailability about 20-fold and self-emulsifying fenugreek galactomannan encapsulation about 62-fold versus aglycone.
19Systolic blood pressureMeta-AnalysisCited 82×n=896 · large study2020
In plain English: Quercetin intake resulted in significantly decreased BP in humans.
Huang H et al. · Nutrition reviews (2020)
Noticeable benefit
← WorseNo effectBetter →
Likely real
Seventeen trials (n = 896) were included.
Pooled results showed that quercetin significantly lowered both systolic BP (WMD, -3.09 mmHg; 95%CI, -4.59 to -1.59; P = 0.0001) and diastolic BP (WMD, -2.86 mmHg; 95%CI, -5.09 to -0.63; P = 0.01).
Neither lipid profiles nor glucose concentrations changed significantly.