Quercetin Dihydrate
Flavonoid with senolytic and anti-inflammatory properties — supports immune defense, allergy relief, and exercise performance.
Quercetin is one of the most abundant flavonoids in the diet, found in onions, apples, berries, and tea. It has potent antioxidant and anti-inflammatory properties. Research shows benefits for immune function, allergies, and exercise performance. Recently gained interest as a potential senolytic (clearing damaged cells) for longevity.
Neutralizes free radicals and supports other antioxidants
Reduces inflammatory signaling
May help clear damaged senescent cells
How Quercetin works — from molecular targets to health outcomes. Click an edge to see supporting research.This visualization is in beta — pathways are being refined and expanded.
500-1000mg
Take with food
| Form | Type |
|---|---|
| 💊Quercetin phytosome (improved absorption) | Recommended |
| 💊Quercetin dihydrate | Alternative |
| 💊Quercetin + bromelain | Alternative |
| 💊Liposomal | Alternative |
Standard quercetin has poor absorption. Phytosome forms or combining with bromelain may improve bioavailability.
Minimum: 4 weeks
Optimal: 8 weeks
Cycling: Not required
Note: Bioavailability is low; taking with fat and vitamin C may help. Some prefer phytosome or liposomal forms for better absorption.
Enhanced immune function and reduced illness
May reduce histamine and allergy symptoms
Lower inflammatory markers
Dietary amounts safe; supplements not well-studied
Avoid high doses; may affect kidney function
May compete for absorption
May have mild antiplatelet effects — may affect platelet aggregation or vitamin K-dependent clotting factors, altering anticoagulant efficacy
May inhibit drug metabolism
Tip: Take with food; reduce dose
Tip: Take with meals
Tip: Reduce dose
Quercetin regenerates vitamin C; vitamin C improves quercetin absorption
Mutual enhancement of antioxidant effects
Quercetin may improve resveratrol bioavailability
Enhanced longevity and antioxidant effects
Quercetin is a zinc ionophore, improving zinc uptake
Enhanced immune support, especially for viral infections
Bromelain enhances quercetin absorption
Enhanced anti-inflammatory and anti-allergy effects
Both are senolytics with different selectivity
Broader senolytic coverage
Both flavonoids with anti-inflammatory effects
Enhanced anti-inflammatory and antihistamine effects
Top studies from 39+ peer-reviewed papers
Okselni T et al. • Naunyn-Schmiedeberg's archives of pharmacology (2025)
“The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.”
Liang H et al. • Renal failure (2025)
“Through rigorous experimental validation, our study demonstrates AS's significant clinical efficacy in managing DN.”
Wu D et al. • Frontiers in immunology (2025)
“This systematic review confirms that the efficacy of dietary polyphenols is significantly composition-specific.”
Zhou P et al. • PloS one (2024)
“The rankings of safety and efficacy of the 12 antioxidants vary.”
Zanjirband M et al. • Journal of cellular and molecular medicine (2024)
“Journal of Cellular and Molecular Medicine”
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