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Qrc6.0
Quercetin Research
Likely helps
250 peer-reviewed studies
What the evidence says
Likely helps
Quercetin appears to help in 12 of 12 studies with measurable effects — the evidence leans clearly favourable.
Most evidence is from high-quality meta-analyses and randomised trials published 1993–2026 with a typical study size of 50 participants.
Based on 250 studies · 33 meta-analyses · 155 RCTs · 908,894 total participants
95 studies in the last 5 years · Latest meta-analysis: 2026
199320092026
1Tyrosinase inhibition and melanin reductionMeta-Analysisn=1,398 · large study2025
Okselni T et al. · Naunyn-Schmiedeberg's archives of pharmacology (2025)
Noticeable benefit
← WorseNo effectBetter →
Furthermore, quercetin significantly inhibited tyrosinase activity (Z-score, 1.95), resulting in a significantly reduced melanin content (Z-score, 2.56).
A significant reduction in DNA damage (Z-score, 3.27), melanoma cell viability (Z-score, 2.97), and tumor formation was also observed to ensure the promising activity of quercetin for skin issues.
This review highlights quercetin's potential as a multifaceted agent in skin care and treatment.
2DAS28 improvementMeta-Analysisn=3,852 · very large study2023
In plain English: Dietary polyphenols may improve DAS28, reduce C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), and improve oxidative stress, etc.
Long Z et al. · Frontiers in immunology (2023)
Dietary polyphenols may improve DAS28, reduce C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), and improve oxidative stress, etc.
However, more RCTs are needed to verify or modify the efficacy and safety of dietary polyphenols.
3ADHD symptom improvementMeta-Analysisn=3,650 · very large study2024
In plain English: The rankings of safety and efficacy of the 12 antioxidants vary.
Zhou P et al. · PloS one (2024)
The rankings of safety and efficacy of the 12 antioxidants vary.
Due to the low methodological quality of the included studies, the probability ranking cannot fully explain the clinical efficacy, and the results need to be interpreted with caution.
More high-quality studies are still needed to verify our findings.
4COPD improvementMeta-Analysisn=894 · large study2025
In plain English: This systematic review confirms that the efficacy of dietary polyphenols is significantly composition-specific.
Wu D et al. · Frontiers in immunology (2025)
This systematic review confirms that the efficacy of dietary polyphenols is significantly composition-specific.
Curcumin and salidroside can improve the course of COPD by regulating blood pressure, inflammation, and the coagulation pathway, supporting the hypothesis of "polyphenol targeting of metabolic-inflammatory networks".
However, the possible negative effects of anthocyanins warn against ingredient heterogeneity.
In plain English: Heat-clearing herbs are useful and promising for the protection against and prevention of ischemic encephalopathy.
Zhao A et al. · Annals of medicine (2024)
Heat-clearing herbs are useful and promising for the protection against and prevention of ischemic encephalopathy.
It can be seen that the components of heat-clearing Chinese medicines can exert cerebroprotective effects through multiple pathways, which provides us with a reference for further development and study of heat-clearing Chinese medicines in the treatment of ischemic cerebrovascular diseases.
18Quercetin bioavailabilityMeta-Analysisn=31 · small study2025
In plain English: This review summarises key factors that enhance quercetin bioavailability, contributing to the development of more effective and practical quercetin supplements or functional foods for better bioac...
Liu L et al. · Food chemistry (2025)
This review summarises key factors that enhance quercetin bioavailability, contributing to the development of more effective and practical quercetin supplements or functional foods for better bioactivity of quercetin in humans.