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Rk2.0

Raspberry Ketones Research

Mostly mechanism / observational

4 peer-reviewed studies

What the evidence says

Mostly mechanism / observational

Most Raspberry Ketones studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.

Most evidence is from medium-quality randomised trials published 2015–2023.

Based on 4 studies · 1 RCT

Confidence

Low confidence

By outcome

Weight managementNo human efficacy trials — weight-loss claims are based only on animal/cell studies · Unknown
Too few graded studies2 studies

Active research area

2 studies in the last 5 years

20152023

1RCT2016

Salacinski AJ, Howell SM, Hill DL, Mauk SM · J Diet Suppl (2016)

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2Review2015

In plain English: Taking into account the high intake via supplements, the compound's toxic potential should be clarified with further experimental studies.

Bredsdorff L et al. · Regul Toxicol Pharmacol (2015)

Used in supplements at intakes far above dietary levels
Few human safety/toxicity data
No human efficacy data cited

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3Animal2023

In plain English: Our findings suggest that RK has a dose-dependent metabolic signature in WAT associated with either weight control or LORR.

Kshatriya D et al. · Food Chem Toxicol (2023)

Altered fat-tissue metabolic gene expression in animals
Preclinical (animal) — not human weight loss
The basis for marketing claims

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4In Vitro2021

In plain English: We propose the first native spectrofluorimetric quality control assay of raspberry ketone, a popular dietary supplement ingredient for weight loss.

Abdelaal SH et al. · Spectrochim Acta A Mol Biomol Spectrosc (2021)

Analytical quality-control study (not efficacy)
Highlights product-content variability
Underscores the lack of clinical data

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View in Research Library

Raspberry Ketones Research

Mostly mechanism / observational

The Acute Effects of Nonstimulant Over-the-Counter Dietary Herbal Supplements on Resting Metabolic Rate.

Raspberry ketone in food supplements--High intake, few toxicity data--A cause for safety concern?

Metabolic gene signature in white adipose tissue of oral doses raspberry ketone [4-(4-hydroxyphenyl)-2-butanone] that prevent diet-induced weight gain and induce loss of righting reflex.

Quality control of dietary supplements: An economic green spectrofluorimetric assay of Raspberry ketone and its application to weight variation testing.