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Rk2.0

Raspberry Ketones Research

Mostly mechanism / observationalModerate safety

3 peer-reviewed studies

What the evidence says

Mostly mechanism / observational

Most Raspberry Ketones studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.

Most evidence is from medium-quality studies published 2015–2023.

Based on 3 studies

Confidence

Very low

By outcome

Weight managementNo human efficacy trials — weight-loss claims are based only on animal/cell studies · Unknown
Too few graded studies1 study

Active research area

2 studies in the last 5 years

20152023

1Review2015

A review noted that raspberry ketone is used in food supplements at high intakes with little toxicity data.

Bredsdorff L et al. · Regul Toxicol Pharmacol (2015)

Used in supplements at intakes far above dietary levels
Few human safety/toxicity data
No human efficacy data cited

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2Animal2023

An animal study examined a metabolic gene signature in adipose tissue after oral raspberry ketone dosing.

Kshatriya D et al. · Food Chem Toxicol (2023)

Altered fat-tissue metabolic gene expression in animals
Preclinical (animal) — not human weight loss
The basis for marketing claims

View source

3In Vitro2021

An analytical study addressed quality control of raspberry-ketone dietary supplements.

Abdelaal SH et al. · Spectrochim Acta A Mol Biomol Spectrosc (2021)

Analytical quality-control study (not efficacy)
Highlights product-content variability
Underscores the lack of clinical data

View source

View in Research Library

Raspberry Ketones Research

Mostly mechanism / observational

Raspberry ketone in food supplements--High intake, few toxicity data--A cause for safety concern?

Metabolic gene signature in white adipose tissue of oral doses raspberry ketone [4-(4-hydroxyphenyl)-2-butanone] that prevent diet-induced weight gain and induce loss of righting reflex.

Quality control of dietary supplements: An economic green spectrofluorimetric assay of Raspberry ketone and its application to weight variation testing.