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Rsv4.5
Resveratrol Research
Likely helps
194 peer-reviewed studies
What the evidence says
Likely helps
Resveratrol appears to help in 10 of 11 studies with measurable effects — the evidence leans clearly favourable.
Most evidence is from high-quality meta-analyses and randomised trials published 2011–2026 with a typical study size of 166 participants.
Based on 194 studies · 61 meta-analyses · 75 RCTs · 21,732 total participants
Confidence
High confidence
What the studies found
10helped1unclear· 183 more without graded effect data
By outcome
Heart & blood pressureModestly improves endothelial function in pooled trials · 4-8 weeks
Likely helps185 studies
Glucose & metabolicReduces insulin resistance in type 2 diabetes; no anti-obesity effect · 8-12 weeks
Likely helps32 studies
InflammationModestly lowers CRP and TNF-a in some trials · 4-8 weeks
125 studies in the last 5 years · Latest meta-analysis: 2026
201120182026
1DAS28 improvementMeta-Analysisn=3,852 · very large study2023
In plain English: Dietary polyphenols may improve DAS28, reduce C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), and improve oxidative stress, etc.
Long Z et al. · Frontiers in immunology (2023)
Dietary polyphenols may improve DAS28, reduce C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), and improve oxidative stress, etc.
However, more RCTs are needed to verify or modify the efficacy and safety of dietary polyphenols.
3BMI reductionMeta-Analysisn=2,173 · very large study2022
In plain English: Based on current evidence, curcumin can reduce BMI, TG, TC, liver enzymes, and insulin resistance; catechin can reduce BMI, insulin resistance, and TG effectively; silymarin can reduce liver enzymes.
Yang K et al. · Frontiers in immunology (2022)
Based on current evidence, curcumin can reduce BMI, TG, TC, liver enzymes, and insulin resistance; catechin can reduce BMI, insulin resistance, and TG effectively; silymarin can reduce liver enzymes.
For resveratrol, naringenin, anthocyanin, hesperidin, and catechin, more RCTs are needed to further evaluate their efficacy and safety.
4Inflammatory markers (TNF-α, hs-CRP)Meta-Analysisn=736 · large study2018
In plain English: Available evidence from RCTs suggests that resveratrol supplementation significantly reduced TNF-α and hs-CRP levels.
Koushki M et al. · Clinical Therapeutics (2018)
The results of meta-analysis found significant reductions in the level of TNF-α (WMD, -0.44; 95% CI, -0.71 to -0.164; P = 0.002) and hs-CRP (WMD, -0.27; 95% CI, -0.5 to -0.02; P = 0.033) after supplementation with resveratrol.
Resveratrol supplementation had no significant effect on the level of IL-6 (WMD, -0.16; 95% CI, -0.53 to 0.20; P = 0.38).
Seventeen RCTs, including 736 subjects, fulfilled the eligibility criteria.
5Multiple health outcomes across 24 indicationsSystematic Reviewn=200 · medium study2024
In plain English: In conclusion, over the last 20 years, the increasing weight of clinical evidence suggests resveratrol can benefit human health, but more large, high-quality clinical trials are required to transition this intriguing compound from health food shops to the clinic.
Brown K et al. · International journal of molecular sciences (2024)
Over the last 20 years, there have been almost 200 studies evaluating resveratrol across at least 24 indications, including cancer, menopause symptoms, diabetes, metabolic syndrome, and cardiovascular disease.
There are currently no consensus treatment regimens for any given condition or endpoint, beyond the fact that resveratrol is generally well-tolerated at a dose of up to 1 g/day.
Additionally, resveratrol consistently reduces inflammatory markers and improves aspects of a dysregulated metabolism.
6Skin wound healing improvementSystematic Reviewn=826 · large study2022
In plain English: The included studies showed promising results that resveratrol might be a feasible treatment approach to support wound healing, counteract excessive scarring, and even prevent photo-aging of the skin.
Hecker A et al. · International wound journal (2022)
The literature search yielded a total of 826 studies, but only 41 studies met the inclusion criteria.
The included studies showed promising results that resveratrol might be a feasible treatment approach to support wound healing, counteract excessive scarring, and even prevent photo-aging of the skin.
Resveratrol represents an interesting and promising novel therapy regime but to confirm resveratrol-associated effects, more evidence based in vitro and in vivo studies are needed.
9Testosterone reductionMeta-Analysisn=218 · medium study2023
In plain English: In combination with other treatments, especially for hyperlipidemia, resveratrol is beneficial for women diagnosed with PCOS.Copyright: Hammad Ali Fadlalmola et al.
Ali Fadlalmola H et al. · The Pan African medical journal (2023)
Noticeable benefit
← WorseNo effectBetter →
Likely real
With 95% confidence intervals, the data was retrieved and analyzed as a mean difference (MD) or a standardized mean difference (SMD).
Resveratrol significantly reduced testosterone (SMD = -0.40; 95% CI [-0.71, -0.10], P = 0.009), luteinizing hormone (LH) (SMD = -0.32; 95% CI [-0.62, 0.01], P = 0.04), and dehydroepiandrosterone sulfate (DHEAS) (MD = -0.85; 95% CI [-1.25, -0.45], P < 0.0001) compared with the placebo.
Four RCTs with 218 women were included in the analysis.
10Prolactin levels improvementMeta-Analysisn=84 · small study2024
In plain English: As per the results of our analysis, resveratrol demonstrates mild therapeutic potential for the sufferers of PCOS, and cannot replace the current established treatment guidelines.
Larik MO et al. · Endocrine (2024)
Likely real
It was observed that resveratrol significantly improved prolactin levels (P = 0.02), acne scores (P = 0.008), and total cholesterol (P = 0.02).
However, there were no significant improvements observed with respect to total testosterone, follicle stimulating hormone (FSH), lutenizing hormone (LH), body mass index (BMI), hirsutism scores, triglycerides, high-density lipoprotein (HDL), and low-density lipoprotein (LDL).
As per the results of our analysis, resveratrol demonstrates mild therapeutic potential for the sufferers of PCOS, and cannot replace the current established treatment guidelines.