Rsv9.0

Resveratrol Research

43 peer-reviewed studies · Evidence score: 9/10

Safety and efficacy of antioxidant therapy in children and adolescents with attention deficit hyperactivity disorder: A systematic review and network meta-analysis

Zhou P et al. • PloS one (2024)

The rankings of safety and efficacy of the 12 antioxidants vary.

The rankings of safety and efficacy of the 12 antioxidants vary.
Due to the low methodological quality of the included studies, the probability ranking cannot fully explain the clinical efficacy, and the results need to be interpreted with caution.
More high-quality studies are still needed to verify our findings.

Meta-Analysisn=3,650

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Efficacy and safety of dietary polyphenols in rheumatoid arthritis: A systematic review and meta-analysis of 47 randomized controlled trials

Long Z et al. • Frontiers in immunology (2023)

Dietary polyphenols may improve DAS28, reduce C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), and improve oxidative stress, etc.

Dietary polyphenols may improve DAS28, reduce C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), and improve oxidative stress, etc.
However, more RCTs are needed to verify or modify the efficacy and safety of dietary polyphenols.
Further research warranted to confirm findings

Meta-Analysisn=3,852

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A Systematic Review and Meta-Analysis of Randomized Controlled Trials on the Impact of Resveratrol Supplementation on Anthropometric Indices in Patients With Type 2 Diabetes

Lahouti M et al. • Phytotherapy research : PTR (2025)

Further high-quality, long-term studies are necessary to confirm these findings.

We determined overall effect sizes using a random-effects model and assessed heterogeneity using the I 2 statistic and Cochrane's Q test.
This meta-analysis revealed significant reductions in body weight, BMI, and WC among T2D patients who consumed resveratrol.
However, we did not find any significant effects on HC or WHR.

Meta-Analysisn=614

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Efficacy and safety of dietary polyphenol supplementation in the treatment of non-alcoholic fatty liver disease: A systematic review and meta-analysis

Yang K et al. • Frontiers in immunology (2022)

Based on current evidence, curcumin can reduce BMI, TG, TC, liver enzymes, and insulin resistance; catechin can reduce BMI, insulin resistance, and TG effectively; silymarin can reduce liver enzymes.

Based on current evidence, curcumin can reduce BMI, TG, TC, liver enzymes, and insulin resistance; catechin can reduce BMI, insulin resistance, and TG effectively; silymarin can reduce liver enzymes.
For resveratrol, naringenin, anthocyanin, hesperidin, and catechin, more RCTs are needed to further evaluate their efficacy and safety.
Further research warranted to confirm findings

Meta-Analysisn=2,173

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Resveratrol for the Management of Human Health: How Far Have We Come? A Systematic Review of Resveratrol Clinical Trials to Highlight Gaps and Opportunities

Brown K et al. • International journal of molecular sciences (2024)

In conclusion, over the last 20 years, the increasing weight of clinical evidence suggests resveratrol can benefit human health, but more large, high-quality clinical trials are required to transition this intriguing compound from health food shops to the clinic.

Over the last 20 years, there have been almost 200 studies evaluating resveratrol across at least 24 indications, including cancer, menopause symptoms, diabetes, metabolic syndrome, and cardiovascular disease.
There are currently no consensus treatment regimens for any given condition or endpoint, beyond the fact that resveratrol is generally well-tolerated at a dose of up to 1 g/day.
Additionally, resveratrol consistently reduces inflammatory markers and improves aspects of a dysregulated metabolism.

Systematic Reviewn=200

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The impact of resveratrol on skin wound healing, scarring, and aging

Hecker A et al. • International wound journal (2022)

International Wound Journal published by Medicalhelplines.com Inc (3M) and John Wiley & Sons Ltd.

The literature search yielded a total of 826 studies, but only 41 studies met the inclusion criteria.
The included studies showed promising results that resveratrol might be a feasible treatment approach to support wound healing, counteract excessive scarring, and even prevent photo-aging of the skin.
Resveratrol represents an interesting and promising novel therapy regime but to confirm resveratrol-associated effects, more evidence based in vitro and in vivo studies are needed.

Systematic Reviewn=826

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Resveratrol and inflammation: A systematic review

Koushki M et al. • Food & Function (2018)

Resveratrol significantly reduced inflammatory markers CRP and TNF-α.

Reduced C-reactive protein
Decreased TNF-α levels
Anti-inflammatory effects confirmed

Systematic Reviewn=1,000

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Efficacy of resveratrol in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized clinical trials

Ali Fadlalmola H et al. • The Pan African medical journal (2023)

In combination with other treatments, especially for hyperlipidemia, resveratrol is beneficial for women diagnosed with PCOS.Copyright: Hammad Ali Fadlalmola et al.

With 95% confidence intervals, the data was retrieved and analyzed as a mean difference (MD) or a standardized mean difference (SMD).
Resveratrol significantly reduced testosterone (SMD = -0.40; 95% CI [-0.71, -0.10], P = 0.009), luteinizing hormone (LH) (SMD = -0.32; 95% CI [-0.62, 0.01], P = 0.04), and dehydroepiandrosterone sulfate (DHEAS) (MD = -0.85; 95% CI [-1.25, -0.45], P < 0.0001) compared with the placebo.
Four RCTs with 218 women were included in the analysis.

Meta-Analysisn=218

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Can resveratrol supplement change inflammatory mediators? A systematic review and meta-analysis on randomized clinical trials

Haghighatdoost F et al. • European journal of clinical nutrition (2019)

The analysis indicated possible decreasing effect of resveratrol on CRP, but it might not be able to change IL-6 and TNF-α concentrations.

Resveratrol intake reduced TNF-α in young subjects (WMD = -0.34; 95% CI: -0.57, -0.12; I2 = 60.5%; P = 0.038) and obese individuals (WMD = -1.52; 95% CI: -2.87, -0.16; I2 = 74.1%; P = 0.004).
The analysis indicated possible decreasing effect of resveratrol on CRP, but it might not be able to change IL-6 and TNF-α concentrations.
More studies, separately on males and females with obesity, and varied age, are necessary.

Meta-Analysisn=658

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Impact of Resveratrol Supplementation on Human Sirtuin 1: A Grading of Recommendations Assessment, Development and Evaluation-Assessed Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials

Mansouri F et al. • Journal of the Academy of Nutrition and Dietetics (2025)

Study results indicate that resveratrol supplementation does not significantly influence human Sirt1 based on the overall meta-analysis.

The results showed no significant impact of resveratrol on Sirt1 gene expression (SMD = 0.05; 95% CI -0.24 to 0.344; P = .73), protein expression (SMD = 0.3; 95% CI -0.15 to 0.77; P = .18), or serum levels (MD = -0.04; 95% CI -0.235 to 0.16; P = .7).
However, subgroup analyses suggested a significant increase in Sirt1 gene expression in studies with an intervention duration of <12 weeks and evaluating blood tissue.
Study results indicate that resveratrol supplementation does not significantly influence human Sirt1 based on the overall meta-analysis.

Meta-Analysis

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Effects of resveratrol on polycystic ovarian syndrome: a systematic review and meta-analysis of randomized controlled trials

Larik MO et al. • Endocrine (2024)

As per the results of our analysis, resveratrol demonstrates mild therapeutic potential for the sufferers of PCOS, and cannot replace the current established treatment guidelines.

It was observed that resveratrol significantly improved prolactin levels (P = 0.02), acne scores (P = 0.008), and total cholesterol (P = 0.02).
However, there were no significant improvements observed with respect to total testosterone, follicle stimulating hormone (FSH), lutenizing hormone (LH), body mass index (BMI), hirsutism scores, triglycerides, high-density lipoprotein (HDL), and low-density lipoprotein (LDL).
As per the results of our analysis, resveratrol demonstrates mild therapeutic potential for the sufferers of PCOS, and cannot replace the current established treatment guidelines.

Meta-Analysisn=84

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Effects of Resveratrol, Curcumin and Quercetin Supplementation on Bone Metabolism-A Systematic Review

Inchingolo AD et al. • Nutrients (2022)

The investigated phenolic compounds seem to positively mediate bone metabolism and osteoclast-related pathologies.

The studies reported the positive effects of the investigated phenolic compounds on bone metabolism and their potential application as adjuvant treatments for osteoporosis, bone tumours, and periodontitis.
Furthermore, their use on the titanium surfaces of orthopaedic prostheses could represent a possible application to improve the osteogenic processes and osseointegration.
According to the study findings, resveratrol, curcumin, and quercetin are reported to have a wide variety of beneficial effects as supplement therapies.

Systematic Reviewn=36

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Engineered production of bioactive polyphenolic O-glycosides

Ren J et al. • Biotechnology advances (2023)

In this review, we systematically review and summarize the representative polyphenolic O-glycosides with various bioactivities and their engineered biosynthesis in microbes with different biotechno...

In this review, we systematically review and summarize the representative polyphenolic O-glycosides with various bioactivities and their engineered biosynthesis in microbes with different biotechnological strategies.
We also review the major routes towards NDP-sugar formation in microbes, which is significant for producing unusual or novel glycosides.
Finally, we discuss the trends in NDP-sugar based glycosylation research to promote the development of prodrugs that positively impact human health and wellness.

Systematic Review

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Resveratrol and Female Fertility: A Systematic Review

Bertoldo A et al. • International journal of molecular sciences (2024)

Further studies are now needed to better understand resveratrol's effects and define the optimal dosage and periods of intake to maximize beneficial effects, as well as to prevent adverse outcomes on implantation, subsequent pregnancy and the fetus.

The current literature, though limited, suggests that resveratrol may play a role in female infertility.
Specifically, it may significantly and positively impact reproductive outcomes, owing to its potential therapeutic effects improving ovarian function.
Further studies are now needed to better understand resveratrol's effects and define the optimal dosage and periods of intake to maximize beneficial effects, as well as to prevent adverse outcomes on implantation, subsequent pregnancy and the fetus.

Systematic Review

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Effects of resveratrol supplementation on bone biomarkers: a systematic review and meta-analysis

Asis M et al. • Annals of the New York Academy of Sciences (2019)

Further precise clinical trials of the effects of resveratrol supplementation on bone health should be conducted.

Pooling six RCTs (eight treatment arms with 264 subjects) together identified no significant reduction of serum Ca, osteocalcin, C-terminal telopeptide of type I collagen, and procollagen I N-terminal propeptide values after resveratrol supplementation over placebo treatment.
The findings of this study indicate that resveratrol supplementation increased some key bone biomarkers, such as ALP and BAP.
Further precise clinical trials of the effects of resveratrol supplementation on bone health should be conducted.

Meta-Analysisn=264

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Cosmeceuticals in photoaging: A review

Chan LKW et al. • Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) (2024)

Topical cosmeceuticals like botanicals, peptides and hydroquinone can effectively treat photodamaged skin.

Topical cosmeceuticals like botanicals, peptides and hydroquinone can effectively treat photodamaged skin.
Further research warranted to confirm findings

Systematic Review

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Resveratrol may mildly improve renal function in the general adult population: A systematic review and meta-analysis of randomized controlled clinical trials

Abdollahi S et al. • Nutrition research (New York, N.Y.) (2023)

The pooled effect sizes were estimated using a random effects model and expressed as weighted mean difference (WMD) and 95% CI.

The pooled effect sizes were estimated using a random effects model and expressed as weighted mean difference (WMD) and 95% CI.
However, higher doses of resveratrol are needed to observe significant reductions in creatinine.
No significant change was observed in albumin, total protein, and uric acid concentrations.

Meta-Analysis

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Effect of resveratrol supplementation on cognitive performance and mood in adults: a systematic literature review and meta-analysis of randomized controlled trials

Marx W et al. • Nutrition reviews (2018)

The results of this review indicate that resveratrol supplementation might improve select measures of cognitive performance; however, the current literature is inconsistent and limited.

Three studies found resveratrol supplementation significantly improved some measures of cognitive performance, 2 reported mixed findings, and 5 found no effect.
Further research warranted to confirm findings

Meta-Analysisn=166

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Pharmaceuticals targeting signaling pathways of endometriosis as potential new medical treatment: A review

Hung SW et al. • Medicinal research reviews (2021)

Medicinal Research Reviews

N-acetyl cysteine, curcumin, and ginsenoside exert antioxidant and anti-inflammatory effects via radical scavenging activity.
Natural products have high efficacy with minimal side effects; for example, resveratrol and epigallocatechin gallate have multiple targets and provide synergistic efficacy to resolve the complexity of the pathophysiology of EM, showing promising efficacy in treating EM.
Although new medical treatments are currently being developed, more detailed pharmacological studies and large sample size clinical trials are needed to confirm the efficacy and safety of these treatments in the near future.

Systematic Review

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Efficacy of dietary supplements on improving sleep quality: a systematic review and meta-analysis

Chan V et al. • Postgraduate medical journal (2022)

Amino acids, vitamin D and melatonin supplements were significantly beneficial to improve sleep quality.

Subjective sleep quality was significantly improved by supplementation of amino acids (MD -1.27, 95% CI -2.35 to -0.20; I2=0%), melatonin (MD -1.21, 95% CI -2.17 to -0.24; I2=79%) and vitamin D (MD -1.63, 95% CI -3.15 to -0.10; I2=85%).
Amino acids, vitamin D and melatonin supplements were significantly beneficial to improve sleep quality.
However, high heterogeneity and wide confidence levels were observed in vitamin D and melatonin.

Meta-Analysis

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