We use essential cookies (authentication, your saved goals/stack) by default. With your permission we'll also enable privacy-respecting analytics (Vercel Web Analytics, anonymous load-time metrics) and error-replay diagnostics (Sentry — DOM snapshots only when an error fires) so we can fix bugs faster. Learn more
Rsv9.0
Resveratrol Research
Likely helpsModerate safety
50 peer-reviewed studies
What the evidence says
Likely helps
Resveratrol appears to help in 8 of 10 studies with measurable effects — the evidence leans clearly favourable.
Most evidence is from high-quality meta-analyses and randomised trials published 2011–2026 with a typical study size of 200 participants.
Based on 50 studies · 23 meta-analyses · 9 RCTs · 17,818 total participants
Confidence
High
What the studies found
8helped2unclear· 40 more without graded effect data
By outcome
Heart & blood pressureImproves endothelial function and reduces arterial stiffness · 4-8 weeks
3Non-alcoholic fatty liver disease parametersMeta-AnalysisCited 64×n=2,173 · very large study2022
Based on current evidence, curcumin can reduce BMI, TG, TC, liver enzymes, and insulin resistance; catechin can reduce BMI, insulin resistance, and TG effectively; silymarin can reduce liver enzymes.
Yang K et al. · Frontiers in immunology (2022)
Based on current evidence, curcumin can reduce BMI, TG, TC, liver enzymes, and insulin resistance; catechin can reduce BMI, insulin resistance, and TG effectively; silymarin can reduce liver enzymes.
For resveratrol, naringenin, anthocyanin, hesperidin, and catechin, more RCTs are needed to further evaluate their efficacy and safety.
4Multiple health outcomes across 24 indicationsSystematic ReviewCited 93×n=200 · medium study2024
In conclusion, over the last 20 years, the increasing weight of clinical evidence suggests resveratrol can benefit human health, but more large, high-quality clinical trials are required to transition this intriguing compound from health food shops to the clinic.
Brown K et al. · International journal of molecular sciences (2024)
Over the last 20 years, there have been almost 200 studies evaluating resveratrol across at least 24 indications, including cancer, menopause symptoms, diabetes, metabolic syndrome, and cardiovascular disease.
There are currently no consensus treatment regimens for any given condition or endpoint, beyond the fact that resveratrol is generally well-tolerated at a dose of up to 1 g/day.
Additionally, resveratrol consistently reduces inflammatory markers and improves aspects of a dysregulated metabolism.
5Skin wound healing improvementSystematic ReviewCited 93×n=826 · large study2022
International Wound Journal published by Medicalhelplines.com Inc (3M) and John Wiley & Sons Ltd.
Hecker A et al. · International wound journal (2022)
The literature search yielded a total of 826 studies, but only 41 studies met the inclusion criteria.
The included studies showed promising results that resveratrol might be a feasible treatment approach to support wound healing, counteract excessive scarring, and even prevent photo-aging of the skin.
Resveratrol represents an interesting and promising novel therapy regime but to confirm resveratrol-associated effects, more evidence based in vitro and in vivo studies are needed.
Study results indicate that resveratrol supplementation does not significantly influence human Sirt1 based on the overall meta-analysis.
Mansouri F et al. · Journal of the Academy of Nutrition and Dietetics (2025)
No clear effect
← WorseNo effectBetter →
Could be chance
The results showed no significant impact of resveratrol on Sirt1 gene expression (SMD = 0.05; 95% CI -0.24 to 0.344; P = .73), protein expression (SMD = 0.3; 95% CI -0.15 to 0.77; P = .18), or serum levels (MD = -0.04; 95% CI -0.235 to 0.16; P = .7).
However, subgroup analyses suggested a significant increase in Sirt1 gene expression in studies with an intervention duration of <12 weeks and evaluating blood tissue.
Study results indicate that resveratrol supplementation does not significantly influence human Sirt1 based on the overall meta-analysis.
9Prolactin levels improvementMeta-AnalysisCited 9×n=84 · small study2024
As per the results of our analysis, resveratrol demonstrates mild therapeutic potential for the sufferers of PCOS, and cannot replace the current established treatment guidelines.
Larik MO et al. · Endocrine (2024)
Likely real
It was observed that resveratrol significantly improved prolactin levels (P = 0.02), acne scores (P = 0.008), and total cholesterol (P = 0.02).
However, there were no significant improvements observed with respect to total testosterone, follicle stimulating hormone (FSH), lutenizing hormone (LH), body mass index (BMI), hirsutism scores, triglycerides, high-density lipoprotein (HDL), and low-density lipoprotein (LDL).
As per the results of our analysis, resveratrol demonstrates mild therapeutic potential for the sufferers of PCOS, and cannot replace the current established treatment guidelines.
10Testosterone reductionMeta-AnalysisCited 25×n=218 · medium study2023
In combination with other treatments, especially for hyperlipidemia, resveratrol is beneficial for women diagnosed with PCOS.Copyright: Hammad Ali Fadlalmola et al.
Ali Fadlalmola H et al. · The Pan African medical journal (2023)
Noticeable benefit
← WorseNo effectBetter →
Likely real
With 95% confidence intervals, the data was retrieved and analyzed as a mean difference (MD) or a standardized mean difference (SMD).
Resveratrol significantly reduced testosterone (SMD = -0.40; 95% CI [-0.71, -0.10], P = 0.009), luteinizing hormone (LH) (SMD = -0.32; 95% CI [-0.62, 0.01], P = 0.04), and dehydroepiandrosterone sulfate (DHEAS) (MD = -0.85; 95% CI [-1.25, -0.45], P < 0.0001) compared with the placebo.
Four RCTs with 218 women were included in the analysis.
11Bone metabolism improvementSystematic ReviewCited 98×n=36 · small study2022
The investigated phenolic compounds seem to positively mediate bone metabolism and osteoclast-related pathologies.
Inchingolo AD et al. · Nutrients (2022)
The studies reported the positive effects of the investigated phenolic compounds on bone metabolism and their potential application as adjuvant treatments for osteoporosis, bone tumours, and periodontitis.
Furthermore, their use on the titanium surfaces of orthopaedic prostheses could represent a possible application to improve the osteogenic processes and osseointegration.
According to the study findings, resveratrol, curcumin, and quercetin are reported to have a wide variety of beneficial effects as supplement therapies.
Further studies are now needed to better understand resveratrol's effects and define the optimal dosage and periods of intake to maximize beneficial effects, as well as to prevent adverse outcomes on implantation, subsequent pregnancy and the fetus.
Bertoldo A et al. · International journal of molecular sciences (2024)
The current literature, though limited, suggests that resveratrol may play a role in female infertility.
Specifically, it may significantly and positively impact reproductive outcomes, owing to its potential therapeutic effects improving ovarian function.
Further studies are now needed to better understand resveratrol's effects and define the optimal dosage and periods of intake to maximize beneficial effects, as well as to prevent adverse outcomes on implantation, subsequent pregnancy and the fetus.
Further precise clinical trials of the effects of resveratrol supplementation on bone health should be conducted.
Asis M et al. · Annals of the New York Academy of Sciences (2019)
Pooling six RCTs (eight treatment arms with 264 subjects) together identified no significant reduction of serum Ca, osteocalcin, C-terminal telopeptide of type I collagen, and procollagen I N-terminal propeptide values after resveratrol supplementation over placebo treatment.
The findings of this study indicate that resveratrol supplementation increased some key bone biomarkers, such as ALP and BAP.
Further precise clinical trials of the effects of resveratrol supplementation on bone health should be conducted.
15Cognitive performance and moodMeta-AnalysisCited 48×n=166 · medium study2018
The results of this review indicate that resveratrol supplementation might improve select measures of cognitive performance; however, the current literature is inconsistent and limited.
Marx W et al. · Nutrition reviews (2018)
Three studies found resveratrol supplementation significantly improved some measures of cognitive performance, 2 reported mixed findings, and 5 found no effect.
16Antioxidant and anti-inflammatory effects in endometriosisSystematic ReviewCited 121×2021
Medicinal Research Reviews
Hung SW et al. · Medicinal research reviews (2021)
N-acetyl cysteine, curcumin, and ginsenoside exert antioxidant and anti-inflammatory effects via radical scavenging activity.
Natural products have high efficacy with minimal side effects; for example, resveratrol and epigallocatechin gallate have multiple targets and provide synergistic efficacy to resolve the complexity of the pathophysiology of EM, showing promising efficacy in treating EM.
Although new medical treatments are currently being developed, more detailed pharmacological studies and large sample size clinical trials are needed to confirm the efficacy and safety of these treatments in the near future.
Amino acids, vitamin D and melatonin supplements were significantly beneficial to improve sleep quality.
Chan V et al. · Postgraduate medical journal (2022)
Noticeable benefit
← WorseNo effectBetter →
Subjective sleep quality was significantly improved by supplementation of amino acids (MD -1.27, 95% CI -2.35 to -0.20; I2=0%), melatonin (MD -1.21, 95% CI -2.17 to -0.24; I2=79%) and vitamin D (MD -1.63, 95% CI -3.15 to -0.10; I2=85%).
Amino acids, vitamin D and melatonin supplements were significantly beneficial to improve sleep quality.
However, high heterogeneity and wide confidence levels were observed in vitamin D and melatonin.
However, future clinical studies are necessary to determine the real efficacy of these compounds in human endometriosis.
Hipólito-Reis M et al. · Phytotherapy research : PTR (2022)
Thirty articles, including a clinical trial, were included.
For the assessment of the quality of the selected studies that globally have "good quality", the GRADE (Grading of Recommendations Assessment, Development and Evaluation) and the SYRCLE ROB tool criteria were used.
However, future clinical studies are necessary to determine the real efficacy of these compounds in human endometriosis.
19Systematic ReviewCited 9×n=19 · very small study2024
To validate these findings and assess their clinical relevance, future research and clinical trials are warranted.
Sienko A et al. · Ginekologia polska (2024)
A total of 215 records were identified, out of which 58 were screened, 23 met the eligibility criteria, and 19 were included in this review.
The results of this systematic review indicate that EPA is suggested to have anti-inflammatory properties and may serve as a potential marker for illness severity.
RES offers a range of advantages, including inflammation reduction, angiogenesis suppression, proliferation inhibition, and apoptosis induction.