We use essential cookies (authentication, your saved goals/stack) by default. With your permission we’ll also enable privacy-respecting analytics (Vercel Web Analytics, anonymous load-time metrics) and error-replay diagnostics (Sentry — DOM snapshots only when an error fires) so we can fix bugs faster. Learn more about cookies
Rsv4.5
Resveratrol Research
Likely helps
35 peer-reviewed studies
Our research database did not respond in time, so this list covers only our curated studies. It refreshes automatically.
What the evidence says
Likely helps
Resveratrol appears to help in 6 of 8 studies with measurable effects — the evidence leans clearly favourable.
Most evidence is from high-quality meta-analyses and randomised trials published 2011–2025 with a typical study size of 119 participants.
Based on 35 studies · 20 meta-analyses · 7 RCTs · 6,396 total participants
Confidence
High confidence
What the studies found
6helped2unclear· 27 more without graded effect data
By outcome
Heart & blood pressureModestly improves endothelial function in pooled trials · 4-8 weeks
2Non-alcoholic fatty liver disease parametersMeta-AnalysisCited 72×n=2,173 · very large study2022
In plain English: Based on current evidence, curcumin can reduce BMI, TG, TC, liver enzymes, and insulin resistance; catechin can reduce BMI, insulin resistance, and TG effectively; silymarin can reduce liver enzymes.
Yang K et al. · Frontiers in immunology (2022)
Based on current evidence, curcumin can reduce BMI, TG, TC, liver enzymes, and insulin resistance; catechin can reduce BMI, insulin resistance, and TG effectively; silymarin can reduce liver enzymes.
For resveratrol, naringenin, anthocyanin, hesperidin, and catechin, more RCTs are needed to further evaluate their efficacy and safety.
3Skin wound healing improvementSystematic ReviewCited 102×n=826 · large study2022
In plain English: The included studies showed promising results that resveratrol might be a feasible treatment approach to support wound healing, counteract excessive scarring, and even prevent photo-aging of the skin.
Hecker A et al. · International wound journal (2022)
The literature search yielded a total of 826 studies, but only 41 studies met the inclusion criteria.
The included studies showed promising results that resveratrol might be a feasible treatment approach to support wound healing, counteract excessive scarring, and even prevent photo-aging of the skin.
Resveratrol represents an interesting and promising novel therapy regime but to confirm resveratrol-associated effects, more evidence based in vitro and in vivo studies are needed.
4Multiple health outcomes across 24 indicationsSystematic ReviewCited 119×n=200 · medium study2024
In plain English: In conclusion, over the last 20 years, the increasing weight of clinical evidence suggests resveratrol can benefit human health, but more large, high-quality clinical trials are required to transition this intriguing compound from health food shops to the clinic.
Brown K et al. · International journal of molecular sciences (2024)
Over the last 20 years, there have been almost 200 studies evaluating resveratrol across at least 24 indications, including cancer, menopause symptoms, diabetes, metabolic syndrome, and cardiovascular disease.
There are currently no consensus treatment regimens for any given condition or endpoint, beyond the fact that resveratrol is generally well-tolerated at a dose of up to 1 g/day.
Additionally, resveratrol consistently reduces inflammatory markers and improves aspects of a dysregulated metabolism.
5Inflammatory markers (TNF-α, hs-CRP)Meta-AnalysisCited 60×n=736 · large study2018
In plain English: Available evidence from RCTs suggests that resveratrol supplementation significantly reduced TNF-α and hs-CRP levels.
Koushki M et al. · Clinical Therapeutics (2018)
The results of meta-analysis found significant reductions in the level of TNF-α (WMD, -0.44; 95% CI, -0.71 to -0.164; P = 0.002) and hs-CRP (WMD, -0.27; 95% CI, -0.5 to -0.02; P = 0.033) after supplementation with resveratrol.
Resveratrol supplementation had no significant effect on the level of IL-6 (WMD, -0.16; 95% CI, -0.53 to 0.20; P = 0.38).
Seventeen RCTs, including 736 subjects, fulfilled the eligibility criteria.
6TNF-α reduction in young subjectsMeta-AnalysisCited 41×n=658 · large study2019
In plain English: The analysis indicated possible decreasing effect of resveratrol on CRP, but it might not be able to change IL-6 and TNF-α concentrations.
Haghighatdoost F et al. · European journal of clinical nutrition (2019)
Noticeable benefit
← WorseNo effectBetter →
Likely real
Resveratrol intake reduced TNF-α in young subjects (WMD = -0.34; 95% CI: -0.57, -0.12; I2 = 60.5%; P = 0.038) and obese individuals (WMD = -1.52; 95% CI: -2.87, -0.16; I2 = 74.1%; P = 0.004).
The analysis indicated possible decreasing effect of resveratrol on CRP, but it might not be able to change IL-6 and TNF-α concentrations.
More studies, separately on males and females with obesity, and varied age, are necessary.
7Prolactin levels improvementMeta-AnalysisCited 10×n=84 · small study2024
In plain English: As per the results of our analysis, resveratrol demonstrates mild therapeutic potential for the sufferers of PCOS, and cannot replace the current established treatment guidelines.
Larik MO et al. · Endocrine (2024)
Likely real
It was observed that resveratrol significantly improved prolactin levels (P = 0.02), acne scores (P = 0.008), and total cholesterol (P = 0.02).
However, there were no significant improvements observed with respect to total testosterone, follicle stimulating hormone (FSH), lutenizing hormone (LH), body mass index (BMI), hirsutism scores, triglycerides, high-density lipoprotein (HDL), and low-density lipoprotein (LDL).
As per the results of our analysis, resveratrol demonstrates mild therapeutic potential for the sufferers of PCOS, and cannot replace the current established treatment guidelines.
In plain English: Study results indicate that resveratrol supplementation does not significantly influence human Sirt1 based on the overall meta-analysis.
Mansouri F et al. · Journal of the Academy of Nutrition and Dietetics (2025)
No clear effect
← WorseNo effectBetter →
Could be chance
The results showed no significant impact of resveratrol on Sirt1 gene expression (SMD = 0.05; 95% CI -0.24 to 0.344; P = .73), protein expression (SMD = 0.3; 95% CI -0.15 to 0.77; P = .18), or serum levels (MD = -0.04; 95% CI -0.235 to 0.16; P = .7).
However, subgroup analyses suggested a significant increase in Sirt1 gene expression in studies with an intervention duration of <12 weeks and evaluating blood tissue.
Study results indicate that resveratrol supplementation does not significantly influence human Sirt1 based on the overall meta-analysis.
9Testosterone reductionMeta-AnalysisCited 26×n=218 · medium study2023
In plain English: In combination with other treatments, especially for hyperlipidemia, resveratrol is beneficial for women diagnosed with PCOS.
Ali Fadlalmola H et al. · The Pan African medical journal (2023)
Noticeable benefit
← WorseNo effectBetter →
Likely real
With 95% confidence intervals, the data was retrieved and analyzed as a mean difference (MD) or a standardized mean difference (SMD).
Resveratrol significantly reduced testosterone (SMD = -0.40; 95% CI [-0.71, -0.10], P = 0.009), luteinizing hormone (LH) (SMD = -0.32; 95% CI [-0.62, 0.01], P = 0.04), and dehydroepiandrosterone sulfate (DHEAS) (MD = -0.85; 95% CI [-1.25, -0.45], P < 0.0001) compared with the placebo.
Four RCTs with 218 women were included in the analysis.
10Bone metabolism improvementSystematic ReviewCited 107×n=36 · small study2022
In plain English: The investigated phenolic compounds seem to positively mediate bone metabolism and osteoclast-related pathologies.
Inchingolo AD et al. · Nutrients (2022)
The studies reported the positive effects of the investigated phenolic compounds on bone metabolism and their potential application as adjuvant treatments for osteoporosis, bone tumours, and periodontitis.
Furthermore, their use on the titanium surfaces of orthopaedic prostheses could represent a possible application to improve the osteogenic processes and osseointegration.
According to the study findings, resveratrol, curcumin, and quercetin are reported to have a wide variety of beneficial effects as supplement therapies.
In plain English: Further studies are now needed to better understand resveratrol's effects and define the optimal dosage and periods of intake to maximize beneficial effects, as well as to prevent adverse outcomes on implantation, subsequent pregnancy and the fetus.
Bertoldo A et al. · International journal of molecular sciences (2024)
The current literature, though limited, suggests that resveratrol may play a role in female infertility.
Specifically, it may significantly and positively impact reproductive outcomes, owing to its potential therapeutic effects improving ovarian function.
Further studies are now needed to better understand resveratrol's effects and define the optimal dosage and periods of intake to maximize beneficial effects, as well as to prevent adverse outcomes on implantation, subsequent pregnancy and the fetus.
In plain English: Further precise clinical trials of the effects of resveratrol supplementation on bone health should be conducted.
Asis M et al. · Annals of the New York Academy of Sciences (2019)
Pooling six RCTs (eight treatment arms with 264 subjects) together identified no significant reduction of serum Ca, osteocalcin, C-terminal telopeptide of type I collagen, and procollagen I N-terminal propeptide values after resveratrol supplementation over placebo treatment.
The findings of this study indicate that resveratrol supplementation increased some key bone biomarkers, such as ALP and BAP.
Further precise clinical trials of the effects of resveratrol supplementation on bone health should be conducted.
14Cognitive performance and moodMeta-AnalysisCited 51×n=166 · medium study2018
In plain English: The results of this review indicate that resveratrol supplementation might improve select measures of cognitive performance; however, the current literature is inconsistent and limited.
Marx W et al. · Nutrition reviews (2018)
Three studies found resveratrol supplementation significantly improved some measures of cognitive performance, 2 reported mixed findings, and 5 found no effect.
15Antioxidant and anti-inflammatory effects in endometriosisSystematic ReviewCited 133×2021
In plain English: Medicinal Research Reviews
Hung SW et al. · Medicinal research reviews (2021)
N-acetyl cysteine, curcumin, and ginsenoside exert antioxidant and anti-inflammatory effects via radical scavenging activity.
Natural products have high efficacy with minimal side effects; for example, resveratrol and epigallocatechin gallate have multiple targets and provide synergistic efficacy to resolve the complexity of the pathophysiology of EM, showing promising efficacy in treating EM.
Although new medical treatments are currently being developed, more detailed pharmacological studies and large sample size clinical trials are needed to confirm the efficacy and safety of these treatments in the near future.
In plain English: Amino acids, vitamin D and melatonin supplements were significantly beneficial to improve sleep quality.
Chan V et al. · Postgraduate medical journal (2022)
Noticeable benefit
← WorseNo effectBetter →
Subjective sleep quality was significantly improved by supplementation of amino acids (MD -1.27, 95% CI -2.35 to -0.20; I2=0%), melatonin (MD -1.21, 95% CI -2.17 to -0.24; I2=79%) and vitamin D (MD -1.63, 95% CI -3.15 to -0.10; I2=85%).
Amino acids, vitamin D and melatonin supplements were significantly beneficial to improve sleep quality.
However, high heterogeneity and wide confidence levels were observed in vitamin D and melatonin.
In plain English: However, future clinical studies are necessary to determine the real efficacy of these compounds in human endometriosis.
Hipólito-Reis M et al. · Phytotherapy research : PTR (2022)
Thirty articles, including a clinical trial, were included.
For the assessment of the quality of the selected studies that globally have "good quality", the GRADE (Grading of Recommendations Assessment, Development and Evaluation) and the SYRCLE ROB tool criteria were used.
However, future clinical studies are necessary to determine the real efficacy of these compounds in human endometriosis.
18Systematic ReviewCited 15×n=19 · very small study2024
In plain English: To validate these findings and assess their clinical relevance, future research and clinical trials are warranted.
Sienko A et al. · Ginekologia polska (2024)
A total of 215 records were identified, out of which 58 were screened, 23 met the eligibility criteria, and 19 were included in this review.
The results of this systematic review indicate that EPA is suggested to have anti-inflammatory properties and may serve as a potential marker for illness severity.
RES offers a range of advantages, including inflammation reduction, angiogenesis suppression, proliferation inhibition, and apoptosis induction.
In plain English: This systematic review with meta-analysis demonstrated that resveratrol supplementation has protective effects on diabetes parameters.
Delpino FM et al. · Critical reviews in food science and nutrition (2022)
Noticeable benefit
← WorseNo effectBetter →
Likely real
Almost 60% demonstrated at least one significant effect of the resveratrol supplementation related to diabetes.
In the meta-analysis, there was a significant effect on the reduction of insulin resistance [SMD: -0.34; CI 95%: -0.64, -0.04; p = 0.01; I2 = 70%] and glycated hemoglobin [SMD: -0.64; CI 95%: -1.22, -0.07; p = 0.01; I2 = 90%].
For fasting blood glucose, the results were significant only for individuals with diabetes [SMD: -0.85; CI 95%: -1.49, -0.21; p = 0.01; I2 = 90%].