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Rsv4.5
Resveratrol Research
Likely helps
205 peer-reviewed studies
What the evidence says
Likely helps
Resveratrol appears to help in 4 of 5 studies with measurable effects — the evidence leans clearly favourable.
Most evidence is from high-quality meta-analyses and randomised trials published 2011–2026 with a typical study size of 110 participants.
Based on 205 studies · 59 meta-analyses · 76 RCTs · 7,678 total participants
Confidence
High confidence
What the studies found
4helped1unclear· 200 more without graded effect data
By outcome
Heart & blood pressureModestly improves endothelial function in pooled trials · 4-8 weeks
Likely helps198 studies
Glucose & metabolicReduces insulin resistance in type 2 diabetes; no anti-obesity effect · 8-12 weeks
Too few graded studies30 studies
InflammationModestly lowers CRP and TNF-a in some trials · 4-8 weeks
136 studies in the last 5 years · Latest meta-analysis: 2026
201120182026
1DAS28 improvementMeta-AnalysisCited 44×n=3,852 · very large study2023
In plain English: Dietary polyphenols may improve DAS28, reduce C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), and improve oxidative stress, etc.
Long Z et al. · Frontiers in immunology (2023)
A total of 49 records (47 RCTs) were included, involving 3852 participants and 15 types of dietary polyphenols. Resveratrol was studied in only 1 of those RCTs.
Dietary polyphenols may improve DAS28, reduce C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), and improve oxidative stress, etc.
The addition of dietary polyphenols did not increase adverse events.
3BMI reductionMeta-AnalysisCited 72×n=2,173 · very large study2022
In plain English: Based on current evidence, curcumin can reduce BMI, TG, TC, liver enzymes, and insulin resistance; catechin can reduce BMI, insulin resistance, and TG effectively; silymarin can reduce liver enzymes.
Yang K et al. · Frontiers in immunology (2022)
The RCTs covered eight polyphenols (curcumin, resveratrol, naringenin, anthocyanin, hesperidin, catechin, silymarin, and genistein) and 2,173 participants.
Based on current evidence, curcumin can reduce BMI, TG, TC, liver enzymes, and insulin resistance; catechin can reduce BMI, insulin resistance, and TG effectively; silymarin can reduce liver enzymes.
For resveratrol, naringenin, anthocyanin, hesperidin, and catechin, more RCTs are needed to further evaluate their efficacy and safety.
4Multiple health outcomes across 24 indicationsSystematic ReviewCited 119×2024
In plain English: In conclusion, over the last 20 years, the increasing weight of clinical evidence suggests resveratrol can benefit human health, but more large, high-quality clinical trials are required to transition this intriguing compound from health food shops to the clinic.
Brown K et al. · International journal of molecular sciences (2024)
Resveratrol has long been proposed as being beneficial to human health across multiple morbidities, yet there is currently no conclusive clinical evidence to advocate its recommendation in any healthcare setting.
Over the last 20 years, there have been almost 200 studies evaluating resveratrol across at least 24 indications, including cancer, menopause symptoms, diabetes, metabolic syndrome, and cardiovascular disease.
There are currently no consensus treatment regimens for any given condition or endpoint, beyond the fact that resveratrol is generally well-tolerated at a dose of up to 1 g/day.
In plain English: The included studies showed promising results that resveratrol might be a feasible treatment approach to support wound healing, counteract excessive scarring, and even prevent photo-aging of the skin.
Hecker A et al. · International wound journal (2022)
The literature search yielded a total of 826 studies, but only 41 studies met the inclusion criteria. The abstract does not say how many were in people.
The included studies showed promising results that resveratrol might be a feasible treatment approach to support wound healing, counteract excessive scarring, and even prevent photo-aging of the skin.
Resveratrol represents an interesting and promising novel therapy regime but to confirm resveratrol-associated effects, more evidence based in vitro and in vivo studies are needed.
8Testosterone reductionMeta-AnalysisCited 26×n=218 · medium study2023
In plain English: Resveratrol significantly reduced testosterone (SMD = -0.40; 95% CI [-0.71, -0.10], P = 0.009), luteinizing hormone (LH) (SMD = -0.32; 95% CI [-0.62, 0.01], P = 0.04), and dehydroepiandrosterone sulfate (DHEAS) (MD = -0.85; 95% CI [-1.25, -0.45], P < 0.0001) compared with the placebo.
Ali Fadlalmola H et al. · The Pan African medical journal (2023)
Noticeable benefit
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Likely real
Four RCTs with 218 women were included in the analysis.
Resveratrol significantly reduced testosterone (SMD = -0.40; 95% CI [-0.71, -0.10], P = 0.009), luteinizing hormone (LH) (SMD = -0.32; 95% CI [-0.62, 0.01], P = 0.04), and dehydroepiandrosterone sulfate (DHEAS) (MD = -0.85; 95% CI [-1.25, -0.45], P < 0.0001) compared with the placebo.
The LH confidence interval reaches past zero (to 0.01) despite the reported P = 0.04.
9Prolactin levels improvementMeta-AnalysisCited 10×n=169 · medium study2024
In plain English: As per the results of our analysis, resveratrol demonstrates mild therapeutic potential for the sufferers of PCOS, and cannot replace the current established treatment guidelines.
Larik MO et al. · Endocrine (2024)
Likely real
It was observed that resveratrol significantly improved prolactin levels (P = 0.02), acne scores (P = 0.008), and total cholesterol (P = 0.02).
However, there were no significant improvements observed with respect to total testosterone, follicle stimulating hormone (FSH), lutenizing hormone (LH), body mass index (BMI), hirsutism scores, triglycerides, high-density lipoprotein (HDL), and low-density lipoprotein (LDL).
As per the results of our analysis, resveratrol demonstrates mild therapeutic potential for the sufferers of PCOS, and cannot replace the current established treatment guidelines.