Morling JR, Yeoh SE, Kolbach DN · Cochrane Database Syst Rev (2015)
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63 peer-reviewed studies
What the evidence says
Most Rutin studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from high-quality meta-analyses and randomised trials published 1982–2026 with a typical study size of 136 participants.
Based on 63 studies · 3 meta-analyses · 57 RCTs · 226 total participants
Confidence
High confidenceBy outcome
Only 3 studies in the last 5 years · Latest meta-analysis: 2015
Morling JR, Yeoh SE, Kolbach DN · Cochrane Database Syst Rev (2015)
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Poynard T, Valterio C · Vasa (1994)
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Aziz Z, Tang WL, Chong NJ, Tho LY · J Clin Pharm Ther (2015)
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In plain English: This comprehensive review serves as a valuable resource summarizing the current knowledge on the antihypertensive effects of specific flavonoids, facilitating further investigation and guiding the development of novel therapeutic strategies for hypertension management.
Harahap U, Syahputra RA, Ahmed A, Nasution A, Wisely W, Sirait ML, Dalimunthe A, Zainalabidin S, Taslim NA, Nurkolis F, Kim B. · Phytotherapy research : PTR (2024)
Morling JR, Yeoh SE, Kolbach DN · Cochrane Database Syst Rev (2015)
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Incandela L, Cesarone MR, DeSanctis MT, Belcaro G, Dugall M, Acerbi G · J Cardiovasc Pharmacol Ther (2002)
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Iding AFJ, Hupperetz RD, Brans RJB, Ten Cate H, van Twist DJL, Ten Cate-Hoek AJ · J Thromb Haemost (2026)
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Prandoni P · Thromb Haemost (2005)
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Cesarone MR, Belcaro G, Brandolini R, Di Renzo A, Bavera P, Dugall M · Angiology (2003)
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Titapant V, Indrasukhsri B, Lekprasert V, Boonnuch W · J Med Assoc Thai (2001)
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Nocker W, Diebschlag W, Lehmacher W · Vasa (1989)
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Belcaro G, Cesarone MR, Nicolaides AN, Geroulakos G, Acerbi G, Candiani C · Clin Appl Thromb Hemost (2003)
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Ott B, Rehn D, Nocker W, Diebschlag W · Vasa Suppl (1991)
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Rehn D, Golden G, Nocker W, Diebschlag W, Lehmacher W · Arzneimittelforschung (1993)
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Piller NB, Morgan RG, Casley-Smith JR · Br J Plast Surg (1988)
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Artaria LG · Klin Monbl Augenheilkd (1982)
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Ortolani O, Caggiano M, Mannelli R, Gogliettino A, Tufano R · Transplant Proc (1995)
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Casley-Smith JR, Casley-Smith JR, Johnson AF, Weston FK · Psychiatry Res (1986)
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Rehn D, Hennings G, Nocker W, Diebschlag W · Eur J Clin Pharmacol (1991)
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Auteri A, Blardi P, Frigerio C, de Lillo L, di Perri T · Int J Clin Pharmacol Res (1990)
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