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4 peer-reviewed studies
What the evidence says
Most Rutin studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from medium-quality meta-analyses and randomised trials published 2006–2015 with a typical study size of 136 participants.
Based on 4 studies · 1 meta-analysis · 2 RCTs · 226 total participants
Confidence
ModerateBy outcome
Newest study from 2015 · Latest meta-analysis: 2015
A systematic review/meta-analysis (15 trials, 1,643 participants) found hydroxyethylrutosides produced modest improvements in several chronic-venous-insufficiency symptoms.
Aziz Z et al. · J Clin Pharm Ther (2015)
A randomized trial (n=90) found oxerutins (Venoruton) improved quality of life in chronic venous insufficiency.
Cesarone MR et al. · Angiology (2006)
A randomized comparative trial evaluated venoactive drugs (including rutosides) for chronic venous disease.
Belczak SQ et al. · Phlebology (2014)
A review covered pharmacological treatment, including rutosides, for advanced (C4-C6) venous disease.
Gohel MS et al. · Phlebology (2010)