17 peer-reviewed studies · Evidence score: 7/10
Zakarija-Grkovic I et al. • The Cochrane database of systematic reviews (2020)
Although some interventions may be promising for the treatment of breast engorgement, such as cabbage leaves, cold gel packs, herbal compresses, and massage, the certainty of evidence is low and we cannot draw robust conclusions about their true effects.
Patil SD et al. • Annales pharmaceutiques francaises (2024)
Serratiopeptidase topical formulations could be more effective than nonsteroidal anti-inflammatory medications in treating local inflammation.
Hosseini SB et al. • Archives of microbiology (2024)
The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Nair SR et al. • Biomolecules (2022)
In addition, the review highlights the therapeutic and clinical aspects of the serratiopeptidase enzyme to combat COVID-19-induced respiratory syndrome.
Kumar SS et al. • Advances in experimental medicine and biology (2019)
Reported enzymes from various sources with potential to be used as cardiovascular therapeutic is also discussed here.
Kotb E • Biotechnology progress (2014)
This review is the first to cover all the natural and recombinant thrombolytic agents used in enzyme therapy.
Bhagat S et al. • International journal of surgery (London, England) (2013)
Serratiopeptidase is being used in many clinical specialities for its anti-inflammatory, anti-edemic and analgesic effects.
Bhagat S et al. • SN Comprehensive Clinical Medicine (2020)
Evidence supports anti-inflammatory effects but more trials needed.
Tamimi Z et al. • BMC oral health (2021)
Serratiopeptidase resulted in better inflammation improvement than placebo over 5 days.
Murugesan K et al. • Indian journal of dental research : official publication of Indian Society for Dental Research (2012)
The results showed dexamethazone was more effective in reduction of swelling and pain in comparison with serratiopaptidase.
Chandanwale A et al. • Advances in therapy (2017)
TC provides a better resolution of symptoms of inflammation after orthopedic surgery as compared to S and TBR, thus facilitating better wound healing.
Chopra D et al. • International journal of oral and maxillofacial surgery (2009)
Mild-to-moderate adverse effects were reported.
Kumari N et al. • Current drug delivery (2012)
The developed optimized sol was satisfactory in terms of taste, syringeability, palatability and incorporation of serratiopeptidase as anti-inflammatory agent, has the potential of developing a therapeutically efficacious system for treatment of periodontal inflammatory anaerobic infections.
Caroppo E et al. • Journal of andrology (2006)
However, the clinical utility of a 90K assay in these patients remains uncertain, as its level is not predictive of response to treatment.
Al-Khateeb TH et al. • International journal of oral and maxillofacial surgery (2008)
There was a significant reduction in the extent of cheek swelling and pain intensity in the serrapeptase group at the 2nd, 3rd and 7th postoperative days (P<0.05), but no significant difference in mean maximal interincisal distance was found between the 2 groups (P>0.05).
Maheshwari M et al. • AAPS PharmSciTech (2006)
Various clinical parameters confirmed the acceptability and efficiency of this gel system.
Artini M et al. • Journal of applied microbiology (2013)
The effect of tested proteases on biofilm formation was not related to the protease category but was strain-dependent and was related to the biofilm formation capacity of each staphylococcal strain.