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Tnp3.8

Tianeptine Research

Mostly mechanism / observational

64 peer-reviewed studies

What the evidence says

Mostly mechanism / observational

Most Tianeptine studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.

Most evidence is from high-quality meta-analyses and randomised trials published 1988–2026 with a typical study size of 1,055 participants.

Based on 64 studies · 8 meta-analyses · 43 RCTs · 1,080 total participants

Confidence

High confidence

By outcome

Safety profile
Mostly mechanism / observational48 studies
Antidepressant effectAt the prescribed dose (12.5 mg three times daily) tianeptine has replicated short-term antidepressant efficacy — at least as effective as SSRIs in a meta-analysis of five RCTs · 1-6 weeks at therapeutic dose
Mostly mechanism / observational35 studies
Anxiety & anxious depressionShows anxiolytic effects alongside its antidepressant action at the therapeutic dose in supervised clinical use · Weeks at therapeutic dose
Mostly mechanism / observational7 studies
Glutamatergic plasticity & stress remodelling
Too few graded studies2 studies

Steady research

8 studies in the last 5 years · Latest meta-analysis: 2023

198820072026

1Meta-Analysis2018

Agabio R, Trogu E, Pani PP · Cochrane Database Syst Rev (2018)

Tianeptine Research

Mostly mechanism / observational

Antidepressants for the treatment of people with co-occurring depression and alcohol dependence.

Efficacy of tianeptine in comparative trials versus reference antidepressants. An overview.

Practitioner Review: Pharmacological treatment of attention-deficit/hyperactivity disorder symptoms in children and youth with autism spectrum disorder: a systematic review and meta-analysis.

[A meta-analysis of randomized controlled trials of tianeptine versus SSRI in the short-term treatment of depression].

Efficacy of antidepressants for late-life depression: a meta-analysis and meta-regression of placebo-controlled randomized trials.

Antidepressants for the treatment of adults with major depressive disorder in the maintenance phase: a systematic review and network meta-analysis.

A meta-analysis of randomized controlled trials of tianeptine versus SSRI in the short-term treatment of depression.

Efficacy of antidepressants for dysthymia: a meta-analysis of placebo-controlled randomized trials.

Antidepressants for depression in stage 3-5 chronic kidney disease: a systematic review of pharmacokinetics, efficacy and safety with recommendations by European Renal Best Practice (ERBP).

Tricyclic antidepressants for autism spectrum disorders (ASD) in children and adolescents.

Adjuvant therapy with antidepressants for the management of inflammatory bowel disease.

Pharmacological and non-pharmacological interventions to improve cognitive dysfunction and functional ability in clinical depression--a systematic review.

Antidepressants in Children and Adolescents: Meta-Review of Efficacy, Tolerability and Suicidality in Acute Treatment.

Use of antidepressive agents as a possibility in the management of periodontal diseases: A systematic review of experimental studies.

Tianeptine in an experimental medicine model of antidepressant action.

[Major depressive episodes in patients over 70 years of age. Evaluation of the efficiency and acceptability of tianeptine and mianserin].

Efficacy of Tianeptine 25-50 mg in Elderly Patients With Recurrent Major Depressive Disorder: An 8-Week Placebo- and Escitalopram-Controlled Study.

[A double-blind controlled study of the efficacy and acceptability of tianeptine in comparison with fluvoxamine in the treatment of depressed alcoholic patients].

Dimensional personality traits and treatment outcome in patients with major depressive disorder.

Influence of food on tianeptine and its main metabolite kinetics.