39 peer-reviewed studies · Evidence score: 7.5/10
Perng CH et al. • Psychopharmacology (2018)
The most effective intervention for dementia available is symptomatic treatment for vascular dementia.
Panda PK et al. • Neurocritical care (2022)
Vinpocetine has some promising efficacy in patients with ischemic stroke when used in the acute stage in reducing the disability, but presently there is not enough evidence to suggest that it also reduces case fatality.
Sawangjit R et al. • Phytotherapy research : PTR (2023)
Therefore, further large and well-designed studies are needed to support the evidence.
Zheng W et al. • Cochrane Database of Systematic Reviews (2020)
Evidence for vinpocetine in acute ischaemic stroke is insufficient to draw conclusions about efficacy or safety.
Szatmari SZ et al. • Cochrane Database of Systematic Reviews (2003)
Vinpocetine appeared to have beneficial effects on cognitive function in patients with cognitive impairment.
Xu H et al. • Oxidative medicine and cellular longevity (2021)
This review will serve as a powerful reference for the screening of phytochemicals with potential clinical applications in ischemic stroke or the synthesis of new neuroprotective agents that take phytochemicals as leading compounds.
Farooq MU et al. • CNS drugs (2017)
However, there is a need for more robust clinical trials focusing on executive function and other cognitive measures and incorporation of newer imaging modalities to provide additional evidence about the utility of these strategies in patients with VCI.
Nabavi SM et al. • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (2019)
Since PDEs are broadly expressed in the brain, PDEIs are considered to modulate neurodegenerative conditions through regulating cAMP and cGMP in the brain.
Zhang YS et al. • European journal of pharmacology (2018)
Due to its excellent safety profile, increasing efforts have been put into exploring the novel therapeutic effects and mechanism of actions of vinpocetine in various cell types and disease models.
Solovyeva EY et al. • Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (2017)
Clinical studies and studies on biological models show that the main mechanisms of action of vinpocetine and 2-ethyl-6-methyl-3-hydroxypyridine-succinate, although have a similar focus, but implementing neuroprotective and nootropic effects via various links in the pathogenesis of ischemic brain damage.
Zhang L et al. • Molecules (Basel, Switzerland) (2014)
This review clarifies the anti-inflammatory role of vinpocetine in atherosclerosis and ischemic stroke.
Muravyov A et al. • Advances in experimental medicine and biology (2012)
And the final red cell microrheological regulatory effect is connected with the crosstalk between these systems.
Patyar S et al. • Pharmacological reports : PR (2011)
The present review focuses on studies investigating the role of vinpocetine in cerebrovascular diseases.
Wang KN et al. • Drugs & aging (2018)
High-quality evidence suggests influenza vaccination reduces hospitalization.
Bagoly E et al. • Orvosi hetilap (2007)
The cited studies showed the potential multi-pharmacological effects of vinpocetine and its beneficial hemorheological potential.
Vas A et al. • Medicinal research reviews (2005)
This systematic-review examined the effects of Vinpocetine.
Zhang W et al. • Clinical drug investigation (2016)
When used as part of treatment for acute cerebral infarction, vinpocetine improves patients' cerebral blood flow, cognitive quality, neurological functions, and QOL.
Zhang P et al. • Pharmacology (2021)
Administration of a combination of vinpocetine and dexamethasone may enhance the anti-inflammatory and anti-oxidative effects when compared to dexamethasone monotherapy, which leads to alleviated cognitive impairment in NPC patients with radiation injury.
Belova LA et al. • Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (2017)
More rapid and complete regression of neurological deficit, better recovery of self-care function, cognitive function and social activity, an increase in erythrocyte membrane elasticity were found in the main group compared to the control one.
Gutiérrez-Farfán I et al. • Journal of pharmacological sciences (2021)
From 6 to 12 months and from 0 to 12 months there were significant differences with a tendency towards improvement, indicating that the aforementioned deterioration not only stopped, but that with ...