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Whg2.5
Wheatgrass Research
Mostly mechanism / observational
7 peer-reviewed studies
What the evidence says
Mostly mechanism / observational
Most Wheatgrass studies are mechanism or observational rather than RCTs that measure a clinical effect — keep findings provisional.
Most evidence is from medium-quality randomised trials published 2002–2026 with a typical study size of 23 participants.
Based on 7 studies · 1 RCT · 39 total participants
Confidence
Low confidence
By outcome
Safety profile
Mostly mechanism / observational3 studies
Active research area
4 studies in the last 5 years
200220142026
1Review2024
In plain English: In this review, we compiled the available evidence pertaining to wheatgrass and its likely impact on CRC, described the pathways of inflammation in which wheatgrass could possibly play a role, and identified future research needs on the subject.
Tamraz M, Al Ghossaini N, Temraz S. · International journal of molecular sciences (2024)
The etiology of colon cancer is either genetic in nature or results from inflammatory bowel diseases such as ulcerative colitis and Crohn's disease; nevertheless, dietary habits play a crucial role in the disease.
In colorectal cancer (CRC), the prospect that wheatgrass possesses anti-inflammatory, antioxidant, and anticancer properties, and its use as an adjunctive therapy, have been minimally investigated and evidence is still limited.
In this review, we compiled the available evidence pertaining to wheatgrass and its likely impact on CRC, described the pathways of inflammation in which wheatgrass could possibly play a role, and identified future research needs on the subject.
In plain English: This narrative review explores the nutritional profile, bioactive compounds, and therapeutic applications of WGJ while addressing its limitations and potential for integration into modern medicine.
Bangera D, Sikalgar FR, Shetty PP, Alva R, Paul Y, Muralidharan S. · Journal of pharmacy & bioallied sciences (2025)
WGJ has demonstrated efficacy in reducing oxidative stress, improving hemoglobin levels in anemia, detoxifying the body, and enhancing immunity.
Additionally, it has shown promise as an adjunct in cancer treatment, cardiovascular health, and gastrointestinal disorders.
Despite its broad usage, most of the evidence supporting WGJ's benefits comes from limited studies, emphasizing the need for more rigorous scientific validation.
In plain English: Creating awareness among consumers about the nutritional profile and therapeutic properties of wheatgrass is crucial in order to maximize its market potential.
Gunjal M, Kaur J, Rasane P, Singh J, Kaur S, Bakshi M, Choudhary R, Marc RA, Ercisli S. · Recent advances in food, nutrition & agriculture (2024)
Recent methods for wheatgrass preservation have been suggested to enhance the bioactive compounds present in wheatgrass.
Conclusion Numerous studies have demonstrated that the consumption of wheatgrass and wheatgrass- based products can help control diabetes, atherosclerosis, kidney and colon diseases, anemia, and certain types of cancer.
The smaller size of wheatgrass allows for easier assimilation of its beneficial compounds.
In plain English: Treatment with wheat grass juice was associated with significant reductions in overall disease activity (P=0.031) and severity of rectal bleeding (P=0.025) in active distal ulcerative colitis.
Ben-Arye E, Goldin E, Wengrower D, et al. · Scand J Gastroenterol (2002)
Randomized double-blind placebo-controlled trial; 23 patients with active distal UC, 100ml juice daily for 1 month
Significant reduction in disease activity index (P=0.031) and rectal bleeding severity (P=0.025); no serious side effects
Very small sample (19 with full data); a single short trial, not replicated at scale
In plain English: However, all the trials were small and a number of methodological problems arose. No adverse events of wheatgrass have been reported, although some forms pose problems of tolerability.
Bar-Sela G, Cohen M, Ben-Arye E, Epelbaum R. · Mini Rev Med Chem (2015)
Reviews wheatgrass composition (chlorophyll, flavonoids, vitamins C/E) and proposed benefits in UC, thalassemia, rheumatoid arthritis, diabetes and chemotherapy support
Notes much of the anticancer mechanism work uses fermented wheat germ extract (a different product) and is in-vitro/animal
Concludes the human evidence is small and methodologically limited; no clinical recommendations yet justified
In plain English: In cells and mice, wheatgrass extract and the flavonoid schaftoside reduced HCl/ethanol-induced gastritis and increased gastric mucus thickness via a mucin-protective pathway.
Chu JW, Kim K, Kim MS, et al. · Food Chem (2026)
Identified schaftoside as a function-linked quality marker connecting wheatgrass to a TRPM5/NCX mucin-protective pathway in AGS cells
In mice, wheatgrass extract (300 mg/kg) and isolated schaftoside (60 mg/kg) reduced experimentally induced gastritis and raised gastric mucus thickness
Mechanistic cell-and-animal study; does not demonstrate a clinical effect in humans
In plain English: Blood transfusion requirement fell by more than 25% in 8 of 16 (50%) transfusion-dependent thalassemia patients consuming ~100ml wheat grass juice daily.
Marwaha RK, Bansal D, Kaur S, Trehan A. · Indian Pediatr (2004)
Pilot study in 16 transfusion-dependent beta-thalassemia patients, each serving as their own control
Transfusion requirement fell >25% in 8/16 patients (>40% in 3 of them); no perceptible adverse effects
Uncontrolled before/after pilot design with a small sample — hypothesis-generating only