38 peer-reviewed studies · Evidence score: 8.5/10
Riley P et al. • The Cochrane database of systematic reviews (2017)
There is some low-quality evidence to suggest that amifostine prevents the feeling of dry mouth in people receiving radiotherapy to the head and neck (with or without chemotherapy) in the short- (end of radiotherapy) to medium-term (three months postradiotherapy).
Mahmoud A et al. • Nutrients (2022)
However, the evidence is still scarce, and larger trials are needed to confirm or refute our findings.
Sureshkumar K et al. • Frontiers in bioscience (Landmark edition) (2023)
Clinical studies were conducted to manage chemotherapy induced toxicities and there are no clinical studies available for its anti-cancer use, and the current evidence does not support its use in the treatment of cardiovascular disease.
Braud A et al. • Clinical oral investigations (2020)
Improving oral hygiene may promote taste ability.
Furihata K et al. • Nutrients (2020)
The dose of 300 mg may be useful among patients with baseline serum zinc concentration of less than 70 µg/dL, and 150 mg for 70 µg/dL or more.
Thomsen M et al. • Current opinion in clinical nutrition and metabolic care (2019)
Zinc effects on the thymic immunological network and T lymphocytes during chemoradiotherapy regimens also warrant further investigation.
Shen W et al. • Medical engineering & physics (2022)
These findings suggest that the efficacy and safety of polaprezinc were similar to those of rebamipide in the treatment of GU.
Tan B et al. • PloS one (2017)
It appears that standard dose polaprezinc combined with triple therapy can significantly improve the H. pylori eradication rate, without an increase in toxicity.
Xiao M et al. • Clinical and translational science (2025)
Clinical and Translational Science
Nakagaki M et al. • Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (2023)
Topical polaprezinc had no effect in the prevention of OM in HSCT patients.
Ikeda M et al. • Nihon Jibiinkoka Gakkai kaiho (2013)
The present study also indicated that examining depressiveness based on the SDS scores and investigating disturbance of each taste quality using the filter-paper disk method are recommended for the diagnosis and determination of the treatment effect of a taste disorder.
Sakagami M et al. • Acta oto-laryngologica (2009)
The effect of a zinc-containing compound, Polaprezinc, was shown to clinically improve the disease conditions of idiopathic taste disorders with no serious side effects in a well controlled double-blinded clinical study.
Kitagawa J et al. • International journal of cancer (2021)
These findings suggest that PZ lozenge is effective for prophylaxis against Grade ≥2 oral mucositis associated with chemotherapy in patients undergoing HSCT without any influence on the HSCT outcome.
Kobayashi H et al. • Nutrients (2015)
Zinc supplementation reduces ERI in patients undergoing HD and may be a novel therapeutic strategy for patients with renal anemia and low serum zinc levels.
Jung DH et al. • Journal of clinical gastroenterology (2021)
The polaprezinc plus PPI treatment showed noninferiority to rebamipide plus PPI treatment in the ulcer healing rate at 4 weeks after ESD.
Okamoto T et al. • Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy (2020)
Clinicians should note the stronger decline in serum copper levels when using ZAH for MHD patients.
Okamoto T et al. • Clinical and experimental nephrology (2020)
Pre-dialysis SCre level was independently associated with responsiveness to zinc supplementation after three months in patients on MHD.
Yoshikawa F et al. • Medicine (2019)
The results of the present study suggest that polaprezinc has an anti-inflammatory effect and improves cardiac function after AMI.
Sharif R et al. • Molecular nutrition & food research (2015)
Zn supplementation may have a beneficial effect in an elderly population with low Zn levels by improving Zn status, antioxidant profile, and lowering DNA damage.
Davison G et al. • The American journal of clinical nutrition (2016)
ZnC, taken alone or with colostrum, increased epithelial resistance and the TJ structure and may have value for athletes and in the prevention of heat stroke in military personnel.