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Head-to-head evidence comparison — which supplement is right for you?
Agmatine vs Magnesium: Magnesium has the stronger overall evidence (8.5 vs 4/10); they're alternatives for reduce anxiety & stress — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Magnesium wins 3 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Likely helps
3 of 3 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
10 of 13 studies with measurable effects showed benefit.
Top outcomes
500-2500mg daily
Empty stomach for mood/nootropic effects, Pre-workout for pumps, Before bed for neuroprotection
Agmatine Sulfate
200-350mg elemental magnesium daily
Evening for sleep/relaxation (glycinate), Morning for energy (malate), Anytime (citrate)
Depends on goal - see notes
and 4 more not shown
2-4 weeks
1-2 weeks
Ongoing
Acute
1-2 weeks
1-2 weeks
1 week
Immediate
Exploring the Cardiovascular Impacts of Agmatine: A Systematic Review
Medical sciences (Basel, Switzerland) (2025) · Systematic review
The effects exerted by AG depend on the dose and route of administration, as well as on the receptors involved and the pathophysiological pathway used.
Role of Inflammatory Mechanisms in Major Depressive Disorder: From Etiology to Potential Pharmacological Targets
Cells (2024) · Review
Together, neuroinflammation and gut dysbiosis induce alterations in tryptophan metabolism, culminating in decreased serotonin synthesis, impairments in neuroplasticity-related mechanisms, and glutamate-mediated excitotoxicity.
Role of agmatine in neurodegenerative diseases and epilepsy
Frontiers in bioscience (Elite edition) (2014) · Review
Agmatine, a cationic polyamine synthesized after decarboxylation of L-arginine by the enzyme arginine decarboxylase, is an endogenous neuromodulator that emerges as a potential agent to manage diverse central nervous system (CNS) disorders.
Magnesium supplementation in pregnancy
The Cochrane database of systematic reviews (2014) · Meta analysis · n=9090
Women receiving magnesium were significantly less likely to require hospitalisation during pregnancy (RR 0.65, 95% CI 0.48 to 0.86; three trials, 1158 women).Of the 10 trials included in the review, only two were judged to be of high quality overall.
Magnesium Supplementation and Blood Pressure: A Systematic Review and Meta-Analysis
Hypertension (2025) · Meta analysis · n=2709
38 RCTs with 2709 participants analyzed
Magnesium and Potassium Supplementation for Systolic Blood Pressure Reduction in the General Normotensive Population: A Systematic Review and Subgroup Meta-Analysis for Optimal Dosage and Treatment Length
Nutrients (2024) · Meta analysis
Both supplements demonstrated greater reductions in SBP for the general population at lower dosages and longer treatment durations.
Based on single pilot study (n=11) showing 46% pain reduction. Very limited evidence with small sample size. GI discomfort may occur at higher doses. Individual variation noted in study.
Based on meta-analysis of 38 RCTs with 2709 participants showing -7.68 mmHg reduction in hypertensive individuals. Effects are greatest in those with hypomagnesemia. Limited evidence in normotensive populations.
AI-estimated from published studies. Interpret as directional guidance.
Magnesium has a higher evidence score (8.5/10 vs 4/10) and wins in 3 of 3 categories.
For reduce anxiety & stress, Magnesium has a higher relevance score (85 vs 55).
No known interactions between Agmatine and Magnesium have been documented in our database. However, always consult a healthcare provider before combining supplements.
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The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.