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Head-to-head evidence comparison — which supplement is right for you?
American Ginseng vs Saccharomyces Boulardii: Saccharomyces Boulardii has the stronger overall evidence (8.5 vs 5.2/10); they're alternatives for support immune system — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Saccharomyces Boulardii wins 3 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Too few graded studies
Top outcomes
Verdict
Likely helps
4 of 4 studies with measurable effects showed benefit.
Top outcomes
200-400mg standardized extract daily (e.g. CVT-E002 for immune use); 1-3g root for glycemic use, taken before meals (a typical label dose, no cited trial states the dose it used)
Morning
Polysaccharide-standardized extract (immune) or root (glycemic)
250-500mg (5-10 billion CFU) daily
With or without food, At least 2 hours away from antifungals
Capsules (lyophilized)
and 1 more not shown
2-16 weeks
4-12 weeks
2-8 weeks
During use
1-3 days
1-2 weeks
Prevention and Treatment of Influenza, Influenza-Like Illness, and Common Cold by Herbal, Complementary, and Natural Therapies.
Journal of evidence-based complementary & alternative medicine (2017) · Review
North American ginseng listed among herbals found effective for respiratory illness
Complementary and alternative medicine for prevention and treatment of the common cold.
Canadian family physician Medecin de famille canadien (2011) · Systematic review
North American ginseng among reviewed cold-prevention options
Ginseng as a Treatment for Fatigue: A Systematic Review.
Journal of alternative and complementary medicine (New York, N.Y.) (2018) · Systematic review
Modest evidence for efficacy across 10 reviewed studies
Efficacy and safety of Saccharomyces boulardii as an adjuvant therapy for the eradication of Helicobacter pylori: a meta-analysis
Frontiers in cellular and infection microbiology (2025) · Meta analysis · n=5036
Meta-analysis of 19 studies with 5,036 people with H. pylori infection, adding S. boulardii to standard eradication therapy.
Probiotics for treating acute infectious diarrhoea
The Cochrane database of systematic reviews (2020) · Meta analysis · n=12127
Effect size was similar in the sensitivity analysis and marked heterogeneity persisted.
The use of probiotics and prebiotics in decolonizing pathogenic bacteria from the gut; a systematic review and meta-analysis of clinical outcomes
Gut microbes (2024) · Meta analysis · n=2871
This review aims to analyze available evidence from human-controlled trials to determine the effect size of probiotic interventions in decolonizing AMR pathogenic bacteria from the gut.
Both points come from a meta-analysis of 10 randomised trials adding S. boulardii to bismuth quadruple therapy (PMID 40251486), whose dose subgroups found the same gain in eradication at 500 mg a day (RR 1.10, 95% CI 1.03 to 1.17) and 1000 mg a day (RR 1.08, 95% CI 1.03 to 1.12). Effectiveness is the relative gain in eradication in percent. Total adverse effects fell with S. boulardii (RR 0.53), so the side effect values are low. The authors recommend 500 mg a day for more than 10 days. The effect is as an add-on to antibiotics only, and doses are in mg of product, not CFU.
AI-estimated from published studies. Interpret as directional guidance.
Saccharomyces Boulardii has a higher evidence score (8.5/10 vs 5.2/10) and wins in 3 of 3 categories.
For support immune system, American Ginseng has a higher relevance score (62 vs 60).
No documented interaction was found in the data searched. This does not establish that this exact combination is safe.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.