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Head-to-head evidence comparison — which supplement is right for you?
Riboflavin wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Likely helps
8 of 9 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
7 of 9 studies with measurable effects showed benefit.
Top outcomes
600-1200mg extract daily
Before meals (especially fatty meals), Divided doses
Standardized leaf extract (2.5-5% cynarin)
25-50mg for general health; 400mg for migraine prevention
With food for better absorption, Morning with other B vitamins
Riboflavin or Riboflavin-5-Phosphate (R-5-P)
2-4 weeks
8-12 weeks
4-8 weeks
3 months
2-4 weeks
Immediate
Lipid-lowering activity of artichoke extracts: A systematic review and meta-analysis
Critical reviews in food science and nutrition (2018) · Meta analysis · n=702
Quantitative data synthesis was performed using a random-effects model, with weighed mean difference (WMD) and 95% confidence interval (CI) as summary statistics.
Functional and Therapeutic Potential of Cynara scolymus in Health Benefits
Nutrients (2024) · Systematic review
This reduces the subsequent risk of developing conditions such as cancer, diabetes, and cardiovascular diseases.
The role of selected nutraceuticals in management of prediabetes and diabetes: An updated review of the literature. Part II
Phytotherapy research : PTR (2024) · Systematic review
Further studies are also required for Cinnamomum, Cynara scolymus, Momordica charantia, Olea europaea, and Opuntia streptacantha.
Effect of Vitamin B2 supplementation on migraine prophylaxis: a systematic review and meta-analysis
Nutritional neuroscience (2022) · Meta analysis · n=673
Vitamin B2 supplementation significantly decreased migraine days (p = .005, I2 = 89%), duration (p = .003, I2 = 0), frequency (p = .001, I2 = 65%), and pain score (p = .015, I2 = 84%).
Effects of selected dietary supplements on migraine prophylaxis: A systematic review and dose-response meta-analysis of randomized controlled trials
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2025) · Meta analysis
In adults, compared with placebo, these supplements did not significantly affect other outcomes, and omega-3 supplementation did not yield a statistically significant reduction in any of these outcomes.
Riboflavin supplements for blood pressure lowering in adults
The Cochrane database of systematic reviews (2025) · Meta analysis · n=320
The evidence for the effect of oral riboflavin supplements on systolic and diastolic blood pressure is very uncertain.
Based on meta-analysis of 702 subjects showing 17.6 mg/dL reduction in total cholesterol. Effect size is modest and may require 6+ weeks to manifest. Limited to artichoke leaf extract studies.
Based on meta-analysis showing significant reduction in migraine frequency, days, duration, and pain score. High heterogeneity (I2=65-89%) in pooled analyses suggests variable individual responses. Most studies used 400mg daily dose.
AI-estimated from published studies. Interpret as directional guidance.
Riboflavin has a higher evidence score (9/10 vs 8.5/10) and wins in 2 of 3 categories.
For reduce inflammation, Artichoke Extract has a higher relevance score (70 vs 45).
No known interactions between Artichoke Extract and Riboflavin have been documented in our database. However, always consult a healthcare provider before combining supplements.