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Head-to-head evidence comparison — which supplement is right for you?
Artichoke Extract and Saccharomyces Boulardii are closely matched across evidence, studies, and safety.
Verdict
Likely helps
8 of 9 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
13 of 15 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Artichoke Extract and Saccharomyces Boulardii have evidence — compare verdict strength side-by-side.
600-1200mg extract daily
Before meals (especially fatty meals), Divided doses
Standardized leaf extract (2.5-5% cynarin)
250-500mg (5-10 billion CFU) daily
With or without food, At least 2 hours away from antifungals
Capsules (lyophilized)
2-4 weeks
8-12 weeks
4-8 weeks
During use
1-3 days
1-2 weeks
Lipid-lowering activity of artichoke extracts: A systematic review and meta-analysis
Critical reviews in food science and nutrition (2018) · Meta analysis · n=702
Quantitative data synthesis was performed using a random-effects model, with weighed mean difference (WMD) and 95% confidence interval (CI) as summary statistics.
Functional and Therapeutic Potential of Cynara scolymus in Health Benefits
Nutrients (2024) · Systematic review
This reduces the subsequent risk of developing conditions such as cancer, diabetes, and cardiovascular diseases.
The role of selected nutraceuticals in management of prediabetes and diabetes: An updated review of the literature. Part II
Phytotherapy research : PTR (2024) · Systematic review
The available evidence showed promising hypoglycemic effects of the nutraceuticals reviewed both for their efficacy and safety profile.
Efficacy and safety of Saccharomyces boulardii as an adjuvant therapy for the eradication of Helicobacter pylori: a meta-analysis
Frontiers in cellular and infection microbiology (2025) · Meta analysis · n=5036
S. boulardii supplementation in traditional eradication therapy significantly improves the H. pylori eradication rate and reduces the total adverse effects and incidence of diarrhea, bloating, constipation, and nausea.
Probiotics for treating acute infectious diarrhoea
The Cochrane database of systematic reviews (2020) · Meta analysis · n=12127
Effect size was similar in the sensitivity analysis and marked heterogeneity persisted.
The use of probiotics and prebiotics in decolonizing pathogenic bacteria from the gut; a systematic review and meta-analysis of clinical outcomes
Gut microbes (2024) · Meta analysis · n=2871
This review aims to analyze available evidence from human-controlled trials to determine the effect size of probiotic interventions in decolonizing AMR pathogenic bacteria from the gut.
Based on meta-analysis of 702 subjects showing 17.6 mg/dL reduction in total cholesterol. Effect size is modest and may require 6+ weeks to manifest. Limited to artichoke leaf extract studies.
Based on multiple meta-analyses showing 1.1-1.6 day reduction in diarrhea duration. Effect size appears to plateau at standard therapeutic doses. Limited data on doses above 20 billion CFU.
AI-estimated from published studies. Interpret as directional guidance.
Both Artichoke Extract and Saccharomyces Boulardii are closely matched — the best choice depends on your specific health goals.
For reduce inflammation, Saccharomyces Boulardii has a higher relevance score (90 vs 70).
No known interactions between Artichoke Extract and Saccharomyces Boulardii have been documented in our database. However, always consult a healthcare provider before combining supplements.