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Head-to-head evidence comparison — which supplement is right for you?
Sildenafil (Viagra) wins 1 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Mostly mechanism / observational
Top outcomes
Shared outcomes (1)
Outcomes where both Avanafil (Stendra) and Sildenafil (Viagra) have evidence — compare verdict strength side-by-side.
Approved on-demand ED dosing is 50-200 mg taken roughly 15-30 minutes before activity (100 mg typical start; range 50-200 mg). It can be taken with or without food. Any use is clinician-directed; this is not a supplement regimen.
any
Oral tablet (avanafil)
Approved on-demand ED dosing is 25-100 mg taken ~30-60 minutes before activity (50 mg typical start). PAH dosing (Revatio) is 20 mg three times daily. Any off-label use is clinician-directed; this is not an approved longevity regimen.
any
Oral tablet (sildenafil citrate)
Acute (~15-30 min onset)
Acute (per dose)
Acute (per dose)
Acute (per dose)
Acute (~30-60 min onset)
Weeks
Years
Years
A randomized, double-blind, placebo-controlled evaluation of the safety and efficacy of avanafil in subjects with erectile dysfunction.
The Journal of Sexual Medicine (2012) · Rct
REVIVE: 12-week phase-3 double-blind, placebo-controlled RCT of on-demand avanafil (50, 100, 200 mg) in men with erectile dysfunction
Avanafil for the treatment of erectile dysfunction: a multicenter, randomized, double-blind study in men with diabetes mellitus.
Mayo Clinic Proceedings (2012) · Rct
REVIVE-Diabetes: 12-week multicenter, randomized, double-blind RCT of avanafil in men with ED and diabetes mellitus
Avanafil for male erectile dysfunction: a systematic review and meta-analysis.
Asian Journal of Andrology (2014) · Meta analysis
Systematic review and meta-analysis pooling randomized placebo-controlled avanafil trials
Oral sildenafil in the treatment of erectile dysfunction.
The New England Journal of Medicine (1998) · Rct
Two sequential double-blind randomized trials of on-demand oral sildenafil in men with erectile dysfunction
Efficacy of PDE-5-inhibitors for erectile dysfunction. A comparative meta-analysis of fixed-dose regimen randomized controlled trials administering the International Index of Erectile Function in broad-spectrum populations.
International Journal of Impotence Research (2006) · Meta analysis
Comparative meta-analysis pooling fixed-dose RCTs of sildenafil, tadalafil, and vardenafil
Sildenafil citrate therapy for pulmonary arterial hypertension.
The New England Journal of Medicine (2005) · Rct
SUPER-1: randomized, double-blind, placebo-controlled trial in 278 patients with PAH
Sildenafil (Viagra) has a higher evidence score (3.8/10 vs 3.6/10) and wins in 1 of 3 categories.
No known interactions between Avanafil (Stendra) and Sildenafil (Viagra) have been documented in our database. However, always consult a healthcare provider before combining supplements.