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Head-to-head evidence comparison — which supplement is right for you?
B-Complex wins 3 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Probably helps
5 of 8 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
6 of 7 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both B-Complex and Pregnenolone have evidence — compare verdict strength side-by-side.
1 capsule daily (per label)
Morning with breakfast
Methylated B-complex (methylcobalamin, methylfolate)
5-50mg daily
Morning (mimics natural production), With or without food
Micronized pregnenolone capsules
2-4 weeks
4-8 weeks
Immediate
2-4 weeks
2-4 weeks
2-4 weeks
Variable
Dosage exploration of combined B-vitamin supplementation in stroke prevention: a meta-analysis and systematic review
The American journal of clinical nutrition (2024) · Meta analysis · n=76664
In areas without and with partial folic acid fortification, combined B-vitamin supplementation significantly reduced the risk of stroke by 34% [RR: 0.66; 95% confidence interval (CI): 0.50, 0.86] and 11% (RR: 0.89; 95% CI: 0.79, 1.00), respectively.
A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Nutrients (2024) · Meta analysis · n=42768
The meta-analysis on the effects of folate-based B vitamin supplementation on cognitive function showed a significant overall impact (Z = 3.84; p = 0.0001; SMD, 0.18; 95% CI, 0.09, 0.28).
A Systematic Review and Meta-Analysis of B Vitamin Supplementation on Depressive Symptoms, Anxiety, and Stress: Effects on Healthy and 'At-Risk' Individuals
Nutrients (2019) · Meta analysis · n=2015
Regarding individual facets of mood, B vitamin supplementation benefited stress (n = 958, SMD = 0.23, 95% CI = 0.02, 0.45, p = 0.03).
Adjunctive use of anti-inflammatory drugs for schizophrenia: A meta-analytic investigation of randomized controlled trials
The Australian and New Zealand journal of psychiatry (2019) · Meta analysis · n=2914
The comparative evaluation of efficacy and safety supported the use of anti-inflammatory adjuvant therapy over the use of antipsychotics alone.
Sex hormones and oxytocin augmentation strategies in schizophrenia: A quantitative review
Schizophrenia research (2015) · Meta analysis · n=1149
Significant effects were found for estrogen action (k=10), regarding total symptoms (Hedges' g=0.63, p=0.001), positive (Hedges' g=0.42, p<0.001), and negative symptoms (Hedges' g=0.35, p=0.001).
Advancements in Non-Dopaminergic Treatments for Schizophrenia: A Systematic Review of Pipeline Developments
Pharmacopsychiatry (2024) · Systematic review
Systematic review examining Pregnenolone efficacy
Multiple meta-analyses show small but statistically significant benefits for cognitive function in older adults and stroke prevention populations. Effect sizes are modest (SMD ~0.15-0.18). Benefits may be more pronounced in B-vitamin deficient populations.
AI-estimated from published studies. Interpret as directional guidance.
B-Complex has a higher evidence score (9/10 vs 8.5/10) and wins in 3 of 3 categories.
For estrogen & progesterone balance, B-Complex has a higher relevance score (85 vs 78).
No known interactions between B-Complex and Pregnenolone have been documented in our database. However, always consult a healthcare provider before combining supplements.