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Head-to-head evidence comparison — which supplement is right for you?
B. coagulans vs B. infantis 35624: B. coagulans has the stronger overall evidence (5 vs 5/10); they're alternatives for improve digestion — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
B. coagulans wins 1 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
Top outcomes
Verdict
Mostly mechanism / observational
Top outcomes
Shared outcomes (1)
Outcomes where both B. coagulans and B. infantis 35624 have evidence — compare verdict strength side-by-side.
1-2 billion CFU (spores) daily. The IBS-D and gas/bloating trials used 2 x 10^9 CFU/day of MTCC 5856 (LactoSpore); the GBI-30 6086 (BC30) studies used 1 x 10^9 CFU/day.
any
Tablet or capsule delivering a named strain — MTCC 5856 (LactoSpore) for IBS, GBI-30 6086 (BC30) for the exercise and amino-acid claims
1 x 10^8 CFU (100 million) daily — the dose that won the only head-to-head dose comparison; 1 x 10^10 CFU also beat placebo in a separate trial, so higher doses are not ruled out
any
Freeze-dried capsule standardized to 35624 at 1 x 10^8 CFU
4-12 weeks
4 weeks
n/a
n/a
4 weeks
4 weeks
n/a
n/a
Outcome-Specific Efficacy of Different Probiotic Strains and Mixtures in Irritable Bowel Syndrome: A Systematic Review and Network Meta-Analysis.
Nutrients (2023) · Meta analysis
B. coagulans MTCC 5856 (SUCRA 96.9%) and B. coagulans Unique IS2 (SUCRA 92.6%) were among the most effective probiotics for improving abdominal pain
Probiotics and synbiotics in chronic constipation in adults: A systematic review and meta-analysis of randomized controlled trials.
Clin Nutr (2022) · Meta analysis
Probiotics increased stool frequency overall (SMD 0.71, 95% CI 0.37-1.04, P<0.00001), with Bifidobacterium lactis driving the effect
The effects of Bacillus coagulans MTCC 5856 on functional gas and bloating in adults: A randomized, double-blind, placebo-controlled study.
Medicine (Baltimore) (2023) · Rct · n=70
GSRS indigestion score fell from 8.91 to 3.06 in the probiotic group versus 9.42 to 8.43 on placebo; between-group P<0.001
Efficacy of an encapsulated probiotic Bifidobacterium infantis 35624 in women with irritable bowel syndrome.
Am J Gastroenterol (2006) · Rct · n=362
1 x 10^8 CFU significantly superior to placebo AND to all other doses for the primary endpoint of abdominal pain
Lactobacillus and bifidobacterium in irritable bowel syndrome: symptom responses and relationship to cytokine profiles.
Gastroenterology (2005) · Rct · n=77
Beat placebo on composite score and on abdominal pain, bloating/distention and bowel-movement difficulty for most treatment weeks
Efficacy of Bifidobacterium infantis 35624 in patients with irritable bowel syndrome: a meta-analysis.
Curr Med Res Opin (2017) · Meta analysis
Single-strain 35624 had no effect on abdominal pain, bloating/distention, or bowel-habit satisfaction
B. coagulans has a higher evidence score (5/10 vs 5/10) and wins in 1 of 3 categories.
Both B. coagulans and B. infantis 35624 score equally (58) for improve digestion.
No known interactions between B. coagulans and B. infantis 35624 have been documented in our database. However, always consult a healthcare provider before combining supplements.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.