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Head-to-head evidence comparison — which supplement is right for you?
Berberine vs Saccharomyces Boulardii: Saccharomyces Boulardii has the stronger overall evidence (8.5 vs 7.5/10); they're alternatives for reduce inflammation — the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Saccharomyces Boulardii wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Likely helps
15 of 19 studies with measurable effects showed benefit.
Top outcomes
Verdict
Likely helps
13 of 15 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (2)
Outcomes where both Berberine and Saccharomyces Boulardii have evidence — compare verdict strength side-by-side.
500mg 2-3x daily (1000-1500mg total)
With meals, Split into 2-3 doses
Berberine HCl capsules
250-500mg (5-10 billion CFU) daily
With or without food, At least 2 hours away from antifungals
Capsules (lyophilized)
4-12 weeks
8-12 weeks
First 2 weeks
If on diabetes medications
During use
1-3 days
1-2 weeks
Clinical Efficacy of Curcumin, Resveratrol, Silymarin, and Berberine on Cardio-Metabolic Risk Factors Among Patients With Type 2 Diabetes Mellitus: A Systemic Review and Bayesian Network Meta-Analysis
Phytotherapy research : PTR (2025) · Meta analysis · n=1337
For HbA1c, silymarin was more effective than resveratrol (MD -2.08, 95%Cl -3.50 to -0.72) (P < 0.05).
Effects of berberine and barberry on selected inflammatory biomarkers in adults: A systematic review and dose-response meta-analysis of randomized clinical trials
Phytotherapy research : PTR (2023) · Meta analysis · n=1600
In addition, the non-linear analysis showed a significant lowering effect of berberine/barberry on IL-6 and TNF-α levels in doses <1000 mg/day and less than 5 weeks of intervention.
Berberine Ursodeoxycholate for the Treatment of Type 2 Diabetes: A Randomized Clinical Trial
JAMA network open (2025) · Rct · n=113
The study included 113 patients with T2D (mean [SD] age, 54.3 [10.6] years; 72 male [63.7%]) who were randomized.
Efficacy and safety of Saccharomyces boulardii as an adjuvant therapy for the eradication of Helicobacter pylori: a meta-analysis
Frontiers in cellular and infection microbiology (2025) · Meta analysis · n=5036
S. boulardii supplementation in traditional eradication therapy significantly improves the H. pylori eradication rate and reduces the total adverse effects and incidence of diarrhea, bloating, constipation, and nausea.
Probiotics for treating acute infectious diarrhoea
The Cochrane database of systematic reviews (2020) · Meta analysis · n=12127
Effect size was similar in the sensitivity analysis and marked heterogeneity persisted.
The use of probiotics and prebiotics in decolonizing pathogenic bacteria from the gut; a systematic review and meta-analysis of clinical outcomes
Gut microbes (2024) · Meta analysis · n=2871
This review aims to analyze available evidence from human-controlled trials to determine the effect size of probiotic interventions in decolonizing AMR pathogenic bacteria from the gut.
Based on meta-analyses showing FPG reduction of 0.59-0.82 mmol/L and HbA1c reduction of 0.63%. Studies primarily used berberine HCl with low bioavailability. Effects require divided doses and may take 8-12 weeks.
Based on multiple meta-analyses showing 1.1-1.6 day reduction in diarrhea duration. Effect size appears to plateau at standard therapeutic doses. Limited data on doses above 20 billion CFU.
AI-estimated from published studies. Interpret as directional guidance.
Saccharomyces Boulardii has a higher evidence score (8.5/10 vs 7.5/10) and wins in 2 of 3 categories.
For reduce inflammation, Berberine has a higher relevance score (95 vs 90).
No known interactions between Berberine and Saccharomyces Boulardii have been documented in our database. However, always consult a healthcare provider before combining supplements.
The honest tier list — proven staples vs situational vs mostly marketing. The hub the other guides feed into.
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Berberine, inositol, magnesium vs the cinnamon/chromium hype — and the med-interaction warning.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.