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Head-to-head evidence comparison — which supplement is right for you?
Bergamot and Nicotinamide Riboside are closely matched across evidence, studies, and safety.
Verdict
Likely helps
4 of 5 studies with measurable effects showed benefit.
Top outcomes
Verdict
Mostly mechanism / observational
2 of 2 studies with measurable effects showed benefit.
Top outcomes
500-1000mg bergamot polyphenolic fraction (BPF)
With meals, Once or twice daily
Bergamot polyphenolic fraction (BPF) — Bergamonte is well-studied
300–500 mg daily
Morning with breakfast, Split dosing (morning and midday) for doses above 500 mg
Nicotinamide Riboside Chloride capsules or powder
4-12 weeks
4-12 weeks
8-12 weeks
1–2 weeks
4–8 weeks
8–16 weeks
4–8 weeks
A network meta-analysis on the comparative effect of nutraceuticals on lipid profile in adults
Pharmacological research (2022) · Meta analysis · n=13062
Evidence for bergamot effect was based on relatively small study group and may require further investigations.
Randomized, Double-Blind, Placebo-Controlled Trial to Test the Effects of a Nutraceutical Combination Monacolin K-Free on the Lipid and Inflammatory Profile of Subjects with Hypercholesterolemia
Nutrients (2022) · Rct · n=118
Compared to the placebo, at 6 and 12 weeks, NC did not significantly reduce total cholesterol (p = 0.083), LDL cholesterol (p = 0.150), and triglycerides (p = 0.822).
Effect of bergamot on lipid profile in humans: A systematic review
Critical reviews in food science and nutrition (2020) · Systematic review · n=442
Although statins can reduce LDLc by 50-60%, less than 20% of patients with high risk of CVD achieve LDL targets.
The Effect of Nicotinamide Mononucleotide and Riboside on Skeletal Muscle Mass and Function: A Systematic Review and Meta-Analysis.
Journal of cachexia, sarcopenia and muscle (2025) · Meta analysis
Systematic review and meta-analysis of RCTs evaluating NMN and NR effects on skeletal muscle mass and function
NAD+ supplementation for anti-aging and wellness: A PRISMA-guided systematic review of preclinical and clinical evidence.
Ageing research reviews (2026) · Systematic review
PRISMA-guided systematic review of both preclinical and clinical NAD+ supplementation literature
NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis.
Experimental gerontology (2020) · Systematic review
Systematic review of 147 articles (113 preclinical, 34 clinical) on NAD+ precursor therapy
Based on systematic review showing 75% of studies had significant effects, but meta-analysis noted small study groups requiring further investigation. One RCT showed no significant reduction at 6-12 weeks.
Based on 8-week RCT showing dose-dependent increases of 22%, 51%, and 142% at 100, 300, and 1000mg respectively. Individual response varies significantly (30% show variable response). NR-SAFE trial confirmed safety up to 2000mg.
AI-estimated from published studies. Interpret as directional guidance.
Both Bergamot and Nicotinamide Riboside are closely matched — the best choice depends on your specific health goals.
For reduce inflammation, Bergamot has a higher relevance score (90 vs 65).
No known interactions between Bergamot and Nicotinamide Riboside have been documented in our database. However, always consult a healthcare provider before combining supplements.