Loading…
We use essential cookies (authentication, your saved goals/stack) by default. With your permission we’ll also enable privacy-respecting analytics (Vercel Web Analytics, anonymous load-time metrics) and error-replay diagnostics (Sentry — DOM snapshots only when an error fires) so we can fix bugs faster. Learn more about cookies
Head-to-head evidence comparison — which supplement is right for you?
Calcium vs L. crispatus CTV-05: Calcium has the stronger overall evidence (8 vs 6/10); the best pick depends on your goals. Take the 60-second quiz for a pick tailored to your goals.
Calcium wins 2 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Likely helps
12 of 13 studies with measurable effects showed benefit.
Top outcomes
Verdict
Mostly mechanism / observational
Top outcomes
1000–1200mg daily (split doses)
Split doses with meals, 500mg with breakfast, 500mg with dinner
Calcium Citrate
VAGINAL USE ONLY, by applicator: 2 x 10^9 CFU per dose. The phase 2b regimen was one dose daily for 5 days in week 1, then twice weekly for a further 10 weeks — always started after a completed course of vaginal metronidazole gel.
any
Vaginal applicator delivering L. crispatus CTV-05
6-24 months
12-36 months
Throughout pregnancy
Within days of starting
11-week dosing course, measured at 12 weeks
n/a
Days 10-28
Persisting to 24 weeks
Effects of combined calcium and vitamin D supplementation on osteoporosis in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials.
Food & Function (2020) · Meta analysis · n=12000
Combined calcium and vitamin D significantly improved lumbar spine BMD in postmenopausal women
Association Between Calcium or Vitamin D Supplementation and Fracture Incidence in Community-Dwelling Older Adults: A Systematic Review and Meta-analysis.
JAMA (2017) · Meta analysis · n=51145
33 trials involving 51,145 participants were analyzed
Vitamin D and Calcium for the Prevention of Fracture: A Systematic Review and Meta-analysis.
JAMA Network Open (2019) · Meta analysis · n=51419
Meta-analysis of 11 randomized clinical trials with 51,419 participants
Randomized Trial of Lactin-V to Prevent Recurrence of Bacterial Vaginosis.
N Engl J Med (2020) · Rct · n=228
Recurrence of bacterial vaginosis by week 12: 30% (46/152) with Lactin-V vs 45% (34/76) with placebo; risk ratio 0.66 (95% CI 0.44-0.87), P=0.01
Response to Antibiotic Treatment of Bacterial Vaginosis Predicts the Effectiveness of LACTIN-V (Lactobacillus crispatus CTV-05) in the Prevention of Recurrent Disease.
Sex Transm Dis (2024) · Observational
This is a POST HOC analysis of the already-completed phase 2b LACTIN-V trial, not a new trial
Sustained effect of LACTIN-V (Lactobacillus crispatus CTV-05) on genital immunology following standard bacterial vaginosis treatment: results from a randomised, placebo-controlled trial.
Lancet Microbe (2022) · Rct · n=66
Vaginal IL-1α was significantly lower with LACTIN-V (β 0.310, SE 0.149; p=0.042)
Based on meta-analysis of 59 RCTs showing 0.6-1.8% BMD increases. Requires vitamin D co-supplementation for optimal effect. Effectiveness plateaus beyond 1200mg daily.
AI-estimated from published studies. Interpret as directional guidance.
Calcium has a higher evidence score (8/10 vs 6/10) and wins in 2 of 3 categories.
No known interactions between Calcium and L. crispatus CTV-05 have been documented in our database. However, always consult a healthcare provider before combining supplements.
The right pick depends on your goals. Answer a few quick questions for a personalised recommendation — or dig into the full evidence on each.