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Head-to-head evidence comparison — which supplement is right for you?
Calcium wins 3 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Likely helps
7 of 8 studies with measurable effects showed benefit.
Top outcomes
Verdict
Mostly mechanism / observational
2 of 2 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Calcium and Sage have evidence — compare verdict strength side-by-side.
1000–1200mg daily (split doses)
Split doses with meals, 500mg with breakfast, 500mg with dinner
Calcium Citrate
300–600 mg standardized extract daily
With breakfast, With dinner (split dosing)
Standardized extract (300–600 mg, 2.5% rosmarinic acid)
6-24 months
12-36 months
Throughout pregnancy
Within days of starting
4–8 weeks
4–8 weeks
4–8 weeks
8–12 weeks
Effects of combined calcium and vitamin D supplementation on osteoporosis in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials.
Food & Function (2020) · Meta analysis · n=12000
Combined calcium and vitamin D significantly improved lumbar spine BMD in postmenopausal women
Association Between Calcium or Vitamin D Supplementation and Fracture Incidence in Community-Dwelling Older Adults: A Systematic Review and Meta-analysis.
JAMA (2017) · Meta analysis · n=51145
33 trials involving 51,145 participants were analyzed
Vitamin D and Calcium for the Prevention of Fracture: A Systematic Review and Meta-analysis.
JAMA Network Open (2019) · Meta analysis · n=51419
Meta-analysis of 11 randomized clinical trials with 51,419 participants
Systematic review of clinical trials assessing pharmacological properties of Salvia species on memory, cognitive impairment and Alzheimer's disease.
CNS Neuroscience & Therapeutics (2014) · Systematic review
Multiple clinical trials demonstrated improvements in memory and attention in healthy young adults following acute and chronic Salvia officinalis or Salvia lavandulaefolia administration.
Exploring the therapeutic impact of Salvia officinalis on lipid and oxidative stress markers in patients with polycystic ovary syndrome - a randomized placebo-controlled clinical trial.
BMC Complementary Medicine and Therapies (2025) · Rct · n=60
Women with PCOS receiving Salvia officinalis extract showed significant reductions in total cholesterol, LDL cholesterol, and triglycerides compared to the placebo group.
Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease
J Clin Pharm Ther (2003) · Rct · n=42
Significant improvement in ADAS-cog and CDR-SB scores vs placebo (P<0.003)
Based on meta-analysis of 59 RCTs showing 0.6-1.8% BMD increases. Requires vitamin D co-supplementation for optimal effect. Effectiveness plateaus beyond 1200mg daily.
Based on multiple RCTs showing improvements in word recall, working memory, and attention. Effects varied by specific cognitive domain and population. Most studies used standardized extracts.
AI-estimated from published studies. Interpret as directional guidance.
Calcium has a higher evidence score (8.8/10 vs 7.8/10) and wins in 3 of 3 categories.
For menopause support, Calcium has a higher relevance score (85 vs 82).
No known interactions between Calcium and Sage have been documented in our database. However, always consult a healthcare provider before combining supplements.