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Head-to-head evidence comparison — which supplement is right for you?
Ceramides wins 1 of 3 categories. Both are solid choices — the best pick depends on your specific goals.
Verdict
Mostly mechanism / observational
2 of 2 studies with measurable effects showed benefit.
Top outcomes
Verdict
Probably helps
7 of 11 studies with measurable effects showed benefit.
Top outcomes
Shared outcomes (1)
Outcomes where both Ceramides and Ginkgo Biloba have evidence — compare verdict strength side-by-side.
350mg wheat-derived ceramides or 30-40mg glycosphingolipids daily
Once daily with food
Wheat-derived phytoceramides (Ceramide-PCD)
120-240mg standardized extract
With meals, Split into 2-3 doses
Standardized extract capsules (EGb 761)
4-8 weeks
8-12 weeks
4-8 weeks
4-6 weeks
4-8 weeks
First week
Ceramides and depression: A systematic review
Journal of affective disorders (2017) · Systematic review · n=14
Pharmacotherapy targeting ceramide metabolism may be a novel treatment option for depression.
Effect of oral intake of phytoceramides on skin hydration: A systematic review and meta-analysis of clinical studies
Journal of Cosmetic Dermatology (2021) · Meta analysis · n=542
Oral phytoceramides significantly increased skin hydration measured by corneometry
Oral supplementation with plant-derived ceramides improves skin barrier function and reduces skin dryness: A randomized, double-blind, placebo-controlled trial
Journal of the European Academy of Dermatology and Venereology (2017) · Rct · n=66
Skin hydration was significantly improved after 60 days of phytoceramide supplementation
Can We Use Ginkgo biloba Extract to Treat Alzheimer's Disease? Lessons from Preclinical and Clinical Studies
Cells (2022) · Meta analysis · n=2100
GBE was shown to reduce the escape latencies in several studies, in both rats and mice (I2 > 70%, p < 0.005).
Beneficial effects of Ginkgo biloba leaf extract on inflammatory markers: A systematic review and meta-analysis of the clinical trials
Phytotherapy research : PTR (2022) · Meta analysis · n=1104
In the meta-analysis, the weighted mean differences (WMD) in change for serum CRP were -1.5 mg/L (95% CI: -2.16, -0.85, p < 0.001).
Miscellaneous treatments for antipsychotic-induced tardive dyskinesia
The Cochrane database of systematic reviews (2018) · Meta analysis · n=1278
Studies were primarily of short (three to six6 weeks) duration with small samples size (10 to 157 participants), and most (61%) were published more than 20 years ago.
Based on multiple meta-analyses including 2100+ participants showing benefits in mild dementia and memory. Effects modest and primarily in older adults or those with existing cognitive decline. Standardized extract (EGb 761) preferred.
AI-estimated from published studies. Interpret as directional guidance.
Ceramides has a higher evidence score (9/10 vs 9/10) and wins in 1 of 3 categories.
No known interactions between Ceramides and Ginkgo Biloba have been documented in our database. However, always consult a healthcare provider before combining supplements.